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HTRA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HTRA1 5654 Druggable Genome

    Alternate Names:

    5654
    HTRA SERINE PEPTIDASE 1
    HTRA1
    ARMD7
    CADASIL2
    CARASIL
    HtrA
    L56
    ORF480
    PRSS11
    602194
    9476
    ENSG00000166033
    OTTHUMG00000019186
    SERINE PROTEASE HTRA1 PRECURSOR (EC 3.4.21.-) (L56). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92743]
    PA33829
    Q92743
    IGFBP5-protease
    Serine protease HTRA1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Tian J et al., 2012, Association of genetic polymorphisms with response to bevacizumab for neovascular age-related macular degeneration in the Chinese population., Pharmacogenomics
    Chang W et al., 2013, Pharmacogenetic association with early response to intravitreal ranibizumab for age-related macular degeneration in a Korean population., Mol Vis
    Park UC et al., 2014, Genetic factors associated with response to intravitreal ranibizumab in Korean patients with neovascular age-related macular degeneration., Retina
    Hagstrom SA et al., 2013, Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT)., Ophthalmology
  • RANIBIZUMAB   HTRA1

    Interaction Score: 35.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22594510 23559864 23842101 23337555


    Sources:
    PharmGKB

  • BEVACIZUMAB   HTRA1

    Interaction Score: 3.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22594510 23559864 23842101 23337555


    Sources:
    PharmGKB

  • Ensembl: ENSG00000166033

    • Version: 101_38

    Alternate Names:
    HTRA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000166033

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000166033 Ensembl Gene Id
    SERINE PROTEASE HTRA1 PRECURSOR (EC 3.4.21.-) (L56). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92743] Description
    PRSS11 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: HTRA1

    • Version: 18-August-2020

    Alternate Names:
    PA33829 PharmGKB ID

    Gene Info:

    Publications:
    Tian J et al., 2012, Association of genetic polymorphisms with response to bevacizumab for neovascular age-related macular degeneration in the Chinese population., Pharmacogenomics
    Chang W et al., 2013, Pharmacogenetic association with early response to intravitreal ranibizumab for age-related macular degeneration in a Korean population., Mol Vis
    Park UC et al., 2014, Genetic factors associated with response to intravitreal ranibizumab in Korean patients with neovascular age-related macular degeneration., Retina

  • NCI: HTRA1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Skórko-Glonek et al., 1999, The Escherichia coli heat shock protease HtrA participates in defense against oxidative stress., Mol. Gen. Genet.

  • HingoraniCasas: ENSG00000166033

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000166033 Gene Symbol
    HTRA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: HTRA1

    • Version: 19.3

    Alternate Names:
    ENSG00000166033 Ensembl Gene ID
    ARMD7 Human Protein Atlas Gene Synonym
    HtrA Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: HTRA1

    • Version: 03-September-2020

    Alternate Names:
    Serine protease HTRA1 Gene Name
    Q92743 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: HTRA1

    • Version: 27-Jun-2013

    Alternate Names:
    5654 Gene ID
    ARMD7 dGene Synonym
    CARASIL dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21