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IFNGR1 Gene Record

  • Summary
  • Interactions
  • Claims
  • IFNGR1 3459 Druggable GenomeClinically Actionable

    Alternate Names:

    3459
    INTERFERON GAMMA RECEPTOR 1
    IFNGR1
    CD119
    IFNGR
    IMD27A
    IMD27B
    107470
    5439
    ENSG00000027697
    OTTHUMG00000015656
    CDw119
    IFN-gamma receptor 1
    IFN-gamma-R1
    IFN-gamma-R-alpha
    Interferon gamma receptor alpha-chain
    CD_antigen=CD119
    P15260
    INGR1_HUMAN

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 2 cytokine receptor
    Target Subclass CytokineR
    Target Subclass IG
    Target Subclass Type2
    Transmembrane Helix Count 1
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Chatterji et al., 2004, Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells., Carcinogenesis
    Matsuda et al., 2007, Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts., Invest. Ophthalmol. Vis. Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Yao et al., 2007, The interferon-gamma receptor gene polymorphisms (Val14Met and Gln64Arg) are not associated with systemic lupus erythematosus in Chinese patients., Arch. Dermatol. Res.
  • INTERFERON GAMMA-1B   IFNGR1

    Interaction Score: 77.29

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:
    Mechanism of Interaction Interferon gamma receptor agonist
    Direct Interaction yes
    Trial Name IRX-2

    PMIDs:
    17251453 11752352 17618444


    Sources:
    TdgClinicalTrial ChemblInteractions

  • INDOLE-3-CARBINOL   IFNGR1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14988219


    Sources:
    NCI

  • Ensembl: ENSG00000027697

    • Version: 101_38

    Alternate Names:
    IFNGR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P15260

    • Version: January-2014

    Alternate Names:
    IFNGR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 2 cytokine receptor

    Publications:

  • TEND: P15260

    • Version: 01-August-2011

    Alternate Names:
    INGR1_HUMAN Uniprot Id
    IFNGR1 Gene Symbol
    3459 Entrez Gene Id

    Gene Info:
    Target Subclass CytokineR
    Target Subclass IG
    Target Subclass Type2

    Publications:

  • NCI: IFNGR1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Chatterji et al., 2004, Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells., Carcinogenesis

  • ChemblInteractions: IFNGR1

    • Version: chembl_23

    Alternate Names:
    IFNGR1 GENE_SYMBOL
    Interferon gamma receptor 1 UNIPROT
    CDw119 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000027697

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000027697 Gene Symbol
    IFNGR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: IFNGR1

    • Version: 11-November-2018

    Alternate Names:
    IFNGR1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • MskImpact: IFNGR1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21