DGIdb - IFNL3 Gene Record

SOFOSBUVIR IFNL3

Interaction Score: 14.55

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Ledipasvir,Sofosbuvir

Combination therapy Sofosbuvir,Velpatasvir

Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

PMIDs:
30431653 29534310 29107709 28100007 27357737 25734178

Sources:
PharmGKB FDA
RIBAVIRIN IFNL3

Interaction Score: 9.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30450628 28739427 28703131 28261910 28072888 27833958 27714501 27514956 27498543 26902034 26825765 26284539 26186989 26032235 26003758 25958342 25918016 25769643 25534433 25287681 25080450 24929144 24907224 24768758 24602923 24362944 24355007 24308755 24117654 24102823 24096968 24072198 23730840 23490377 23383658 23321318 23281610 23142377 22863269 22626609 22438096 22345656 22328925 22301466 21993426 21987611 21951981 21911885 21907615 21745312 21739446 21726252 21606533 21572301 21537116 21503910 21466653 21447862 21390311 21384511 21374656 21360545 21346780 21254157 21246582 21145807 21112660 21112657 21068134 20964522 20804372 20728570 20648473 20621700 20578254 20434452 20399780 20060832 19749758 19749757 19684573

Sources:
PharmGKB
LEDIPASVIR IFNL3

Interaction Score: 9.09

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Ledipasvir,Sofosbuvir

PMIDs:
28100007 27357737 25734178

Sources:
PharmGKB FDA
DACLATASVIR IFNL3

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30431653 25080450

Sources:
PharmGKB FDA
DASABUVIR IFNL3

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
PharmGKB FDA
TELAPREVIR IFNL3

Interaction Score: 7.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24362944 24117654 24096968 23321318 21246582 20648473

Sources:
PharmGKB FDA
VOXILAPREVIR IFNL3

Interaction Score: 5.46

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

PMIDs:
29107709

Sources:
PharmGKB FDA
VELPATASVIR IFNL3

Interaction Score: 5.46

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

Combination therapy Sofosbuvir,Velpatasvir

PMIDs:
29107709

Sources:
PharmGKB FDA
DELEOBUVIR IFNL3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23944300

Sources:
PharmGKB
OMBITASVIR IFNL3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
FDA
ELBASVIR IFNL3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Elbasvir,Grazoprevir

PMIDs:
None found

Sources:
FDA
FALDAPREVIR IFNL3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23944300

Sources:
PharmGKB
GRAZOPREVIR IFNL3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Elbasvir,Grazoprevir

PMIDs:
None found

Sources:
FDA
PARITAPREVIR IFNL3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
FDA
BOCEPREVIR IFNL3

Interaction Score: 2.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25836019 24096968 22626609

Sources:
PharmGKB FDA
SIMEPREVIR IFNL3

Interaction Score: 2.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28072888 24907224 24602923

Sources:
PharmGKB FDA
RITONAVIR IFNL3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
FDA

Ensembl: ENSG00000197110
- Version: 101_38
Alternate Names:

IFNL3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: IFNL3

Version: 18-August-2020

Alternate Names:

PA134952671 PharmGKB ID

Gene Info:

Publications:

Cusato J et al., 2015, Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics., Int J Antimicrob Agents

Muir AJ et al., 2014, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-α-based regimens., Clin Pharmacol Ther

Poordad F et al., 2012, Factors that predict response of patients with hepatitis C virus infection to boceprevir., Gastroenterology

HingoraniCasas: ENSG00000197110
- Version: 31-May-2017
Alternate Names:

ENSG00000197110 Gene Symbol

IFNL3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: IFNL3
- Version: 11-November-2018
Alternate Names:

IFNL3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FDA: IFNL3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Combination therapy	Ledipasvir,Sofosbuvir
Combination therapy	Sofosbuvir,Velpatasvir
Combination therapy	Sofosbuvir,Velpatasvir,Voxilaprevir

Combination therapy	Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir
Combination therapy	Ombitasvir,Paritaprevir,Ritonavir

282617
INTERFERON LAMBDA 3
IFNL3
IFN-lambda-3
IFN-lambda-4
IL-28B
IL-28C
IL28B
IL28C
607402
18365
ENSG00000197110
OTTHUMG00000182805
PA134952671

IFNL3 Gene Record

IFNL3 282617 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Ledipasvir,Sofosbuvir Combination therapy Sofosbuvir,Velpatasvir Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

PMIDs: 30431653 29534310 29107709 28100007 27357737 25734178

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Ledipasvir,Sofosbuvir

PMIDs: 28100007 27357737 25734178

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30431653 25080450

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24362944 24117654 24096968 23321318 21246582 20648473

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

PMIDs: 29107709

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir Combination therapy Sofosbuvir,Velpatasvir

PMIDs: 29107709

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23944300

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Elbasvir,Grazoprevir

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23944300

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Elbasvir,Grazoprevir

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25836019 24096968 22626609

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28072888 24907224 24602923

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs: None found

Sources: FDA

Ensembl: ENSG00000197110

Alternate Names: IFNL3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: IFNL3

Alternate Names: PA134952671 PharmGKB ID

Gene Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Ledipasvir,Sofosbuvir

Combination therapy Sofosbuvir,Velpatasvir

Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

PMIDs:
30431653 29534310 29107709 28100007 27357737 25734178

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Ledipasvir,Sofosbuvir

PMIDs:
28100007 27357737 25734178

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
30431653 25080450

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
24362944 24117654 24096968 23321318 21246582 20648473

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

PMIDs:
29107709

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sofosbuvir,Velpatasvir,Voxilaprevir

Combination therapy Sofosbuvir,Velpatasvir

PMIDs:
29107709

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
23944300

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Elbasvir,Grazoprevir

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
23944300

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Elbasvir,Grazoprevir

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
25836019 24096968 22626609

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
28072888 24907224 24602923

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Dasabuvir,Ombitasvir,Paritaprevir,Ritonavir

Combination therapy Ombitasvir,Paritaprevir,Ritonavir

PMIDs:
None found

Sources:
FDA

Alternate Names:

IFNL3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA134952671 PharmGKB ID

Alternate Names:

ENSG00000197110 Gene Symbol

IFNL3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IFNL3 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE