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IL11 Gene Record

  • Summary
  • Interactions
  • Claims
  • IL11 3589 Druggable Genome

    Alternate Names:

    3589
    INTERLEUKIN 11
    IL11
    AGIF
    IL-11
    147681
    5966
    ENSG00000095752
    OTTHUMG00000180789
    PA29781
    Interleukin-11
    T56308
    P20809

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    KINASE
    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Engel et al., 2003, Alendronate and etidronate do not regulate interleukin 6 and 11 synthesis in normal human osteoblasts in culture., Calcif. Tissue Int.
    López-Karpovitch et al., 2002, Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia., Cytokine
    Musashi et al., 1991, Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice., Blood
    Katayama et al., 1993, Stage-specific expression of c-kit protein by murine hematopoietic progenitors., Blood
    Powell TR et al., 2013, Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response., Eur Neuropsychopharmacol
    Lin E et al., 2015, Genome-wide association studies in pharmacogenomics of antidepressants., Pharmacogenomics
    Isaacs et al., 1997, Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin., J. Clin. Oncol.
  • ALENDRONIC ACID   IL11

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12522661


    Sources:
    NCI

  • ETIDRONIC ACID   IL11

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12522661


    Sources:
    NCI

  • ESCITALOPRAM   IL11

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23142150


    Sources:
    PharmGKB

  • CITALOPRAM   IL11

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25916525


    Sources:
    PharmGKB

  • AZACITIDINE   IL11

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12543079


    Sources:
    NCI

  • FLUOROURACIL   IL11

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1832057 7691257


    Sources:
    NCI

  • DOXORUBICIN   IL11

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9363868


    Sources:
    NCI

  • Ensembl: ENSG00000095752

    • Version: 101_38

    Alternate Names:
    IL11 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: IL11

    • Version: 18-August-2020

    Alternate Names:
    PA29781 PharmGKB ID

    Gene Info:

    Publications:
    Powell TR et al., 2013, Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response., Eur Neuropsychopharmacol
    Lin E et al., 2015, Genome-wide association studies in pharmacogenomics of antidepressants., Pharmacogenomics

  • NCI: IL11

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Engel et al., 2003, Alendronate and etidronate do not regulate interleukin 6 and 11 synthesis in normal human osteoblasts in culture., Calcif. Tissue Int.
    Musashi et al., 1991, Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice., Blood
    Kobayashi et al., 1993, Interleukin-11 acts as an autocrine growth factor for human megakaryoblastic cell lines., Blood

  • HingoraniCasas: ENSG00000095752

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000095752 Gene Symbol
    IL11 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Interleukin-11

    • Version: 2020.06.01

    Alternate Names:
    IL11 TTD Gene Abbreviation
    T56308 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: IL11

    • Version: 01-February-2022

    Alternate Names:
    Interleukin-11 Gene Name
    P20809 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: IL11

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21