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IL15 Gene Record

  • Summary
  • Interactions
  • Claims
  • IL15 3600 Druggable Genome

    Alternate Names:

    3600
    INTERLEUKIN 15
    IL15
    IL-15
    600554
    5977
    ENSG00000164136
    OTTHUMG00000133418
    P40933
    INTERLEUKIN-15
    T32240

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    KINASE
    DRUGGABLE GENOME

    Publications:

    Gangemi et al., 2003, Effect of levodopa on interleukin-15 and RANTES circulating levels in patients affected by Parkinson's disease., Mediators Inflamm.
    Yajima et al., 2004, Overexpression of Interleukin-15 increases susceptibility to lipopolysaccharide-induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin., Infect. Immun.
    Umemura et al., 2001, Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guérin infection via augmentation of NK and T cytotoxic 1 responses., J. Immunol.
    Cho et al., 2002, Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes., Arthritis Rheum.
    Baan et al., 2001, Conversion from cyclosporin A to tacrolimus is safe and decreases blood pressure, cholesterol levels and TGF-beta 1 type I receptor expression., Clin Transplant
    Lewis et al., 2001, Interleukin-15 is the main mediator of lymphocyte proliferation in cultures mixed with human kidney tubular epithelial cells., Transplantation
    Dubois et al., 2003, Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells., Proc. Natl. Acad. Sci. U.S.A.
  • AMG-714   IL15

    Interaction Score: 24.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-15 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • BCG VACCINE   IL15

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15213127 11441103


    Sources:
    NCI

  • CYCLOSPORINE   IL15

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11817607 11683823 11571455


    Sources:
    NCI

  • LEVODOPA   IL15

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14514477


    Sources:
    NCI

  • SIROLIMUS   IL15

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14605212


    Sources:
    NCI

  • Ensembl: ENSG00000164136

    • Version: 101_38

    Alternate Names:
    IL15 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P40933

    • Version: January-2014

    Alternate Names:
    IL15 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine

    Publications:

  • NCI: IL15

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Umemura et al., 2001, Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guérin infection via augmentation of NK and T cytotoxic 1 responses., J. Immunol.
    Yajima et al., 2004, Overexpression of Interleukin-15 increases susceptibility to lipopolysaccharide-induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin., Infect. Immun.
    Liu et al., 2000, IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production., J. Immunol.

  • HingoraniCasas: ENSG00000164136

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164136 Gene Symbol
    IL15 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: IL15

    • Version: chembl_23

    Alternate Names:
    IL15 GENE_SYMBOL
    Interleukin-15 UNIPROT
    IL-15 UNIPROT

    Gene Info:

    Publications:

  • Tempus: IL15

    • Version: 11-November-2018

    Alternate Names:
    IL15 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Interleukin-15

    • Version: 2020.06.01

    Alternate Names:
    IL15 TTD Gene Abbreviation
    T32240 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: IL15

    • Version: 01-February-2022

    Alternate Names:
    Interleukin-15 Gene Name
    P40933 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: IL15

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21