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IL18 Gene Record

  • Summary
  • Interactions
  • Claims
  • IL18 3606 Druggable Genome

    Alternate Names:

    3606
    INTERLEUKIN 18
    IL18
    IGIF
    IL-18
    IL-1g
    IL1F4
    600953
    5986
    ENSG00000150782
    OTTHUMG00000167006
    INTERLEUKIN-18
    PA29802
    T06671

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Jensen LE, 2010, Targeting the IL-1 family members in skin inflammation., Curr Opin Investig Drugs
    Fan J et al., 2015, Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies., Pharmacogenomics
    Xing J et al., 2015, Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients., Eur J Clin Pharmacol
    Kuinose et al., 2000, Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions., Acta Med. Okayama
    Antoniou et al., 2004, Th1 cytokine pattern (IL-12 and IL-18) in bronchoalveolar lavage fluid (BALF) before and after treatment with interferon gamma-1b (IFN-gamma-1b) or colchicine in patients with idiopathic pulmonary fibrosis (IPF/UIP)., Sarcoidosis Vasc Diffuse Lung Dis
    Botella-Carretero et al., 2005, The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal., Eur. J. Endocrinol.
    Caramori G et al., 2014, Cytokine inhibition in the treatment of COPD., Int J Chron Obstruct Pulmon Dis
    Haas SL et al., 2009, Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response., J Clin Immunol
  • MEDI-2338   IL18

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24812504


    Sources:
    TTD

  • GSK-1070806   IL18

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21157640


    Sources:
    TTD

  • IBOCTADEKIN   IL18

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THYROXINE   IL18

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16061828


    Sources:
    NCI

  • TACROLIMUS   IL18

    Interaction Score: 1.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25712187 25487141 11061569


    Sources:
    NCI PharmGKB

  • RIBAVIRIN   IL18

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19455410


    Sources:
    PharmGKB

  • COLCHICINE   IL18

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15281431


    Sources:
    NCI

  • Ensembl: ENSG00000150782

    • Version: 101_38

    Alternate Names:
    IL18 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: IL18

    • Version: 18-August-2020

    Alternate Names:
    PA29802 PharmGKB ID

    Gene Info:

    Publications:
    Haas SL et al., 2009, Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response., J Clin Immunol
    Fan J et al., 2015, Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies., Pharmacogenomics
    Xing J et al., 2015, Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients., Eur J Clin Pharmacol

  • TTD: Interleukin-18

    • Version: 2020.06.01

    Alternate Names:
    IL18 TTD Gene Abbreviation
    T06671 TTD Target ID

    Gene Info:

    Publications:
    Jensen LE, 2010, Targeting the IL-1 family members in skin inflammation., Curr Opin Investig Drugs
    Caramori G et al., 2014, Cytokine inhibition in the treatment of COPD., Int J Chron Obstruct Pulmon Dis

  • NCI: IL18

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Myśliwiec et al., 2003, Interleukin 18 and transforming growth factor beta1 in the serum of patients with Graves' ophthalmopathy treated with corticosteroids., Int. Immunopharmacol.
    Lee et al., 2005, IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response., Cancer Lett.
    Kolodziej et al., 2005, Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells., Bioorg. Med. Chem.

  • HingoraniCasas: ENSG00000150782

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000150782 Gene Symbol
    IL18 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21