DGIdb - IL1R1 Gene Record

IL1R1 3554 Druggable Genome

Alternate Names:

3554
INTERLEUKIN 1 RECEPTOR TYPE 1
IL1R1
CD121A
D2S1473
IL-1R-alpha
IL1R
IL1RA
P80
147810
5993
ENSG00000115594
OTTHUMG00000130783
Interleukin-1 receptor alpha
IL1RT1
Interleukin-1 receptor type 1
Interleukin-1 receptor type 1, membrane form
Interleukin-1 receptor type 1, soluble form
CD121 antigen-like family member A
Interleukin-1 receptor type I
CD_antigen=CD121a
IL-1R-1
IL-1RT-1
IL-1RT1
mIL-1R1
mIL-1RI
sIL-1R1
sIL-1RI
P14778
IL1R1_HUMAN
T72515

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Target Subclass	IG
Target Subclass	CytokineR
Target Subclass	Type1
Target Main Class	Receptors
Transmembrane Helix Count	1
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Vannier et al., 1999, Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy., Eur. Cytokine Netw.
So et al., 2007, A pilot study of IL-1 inhibition by anakinra in acute gout., Arthritis Res. Ther.
Do et al., 2006, Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort., J. Infect. Dis.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tang et al., 2007, [Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1 beta, its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats]., Zhong Xi Yi Jie He Xue Bao
Vamvakopoulos et al., 2002, Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist., Eur. J. Immunol.
Dayer, 2003, The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis., Rheumatology (Oxford)
Haq et al., 1998, Role of IL-1 in renal ischemic reperfusion injury., J. Am. Soc. Nephrol.
Takii et al., 1999, Tyrosine kinase is essential for the constitutive expression of type I interleukin-1 receptor in human fibroblast cells., Eur. Cytokine Netw.
Blanco et al., 2005, Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes., J. Immunol.
Savino et al., 2006, Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis., J. Neuroimmunol.
Kalechman et al., 1995, Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties., Immunopharmacology

ANAKINRA IL1R1

Interaction Score: 16.75

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 receptor antagonist

Direct Interaction yes

Trial Name anakinra,Kineret

PMIDs:
10210771 17352828 17083033 11752352 17498496 12355453 12817089 9555664

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD
AMMONIUM TRICHLOROTELLURATE IL1R1

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7539780

Sources:
NCI
AMG-108 IL1R1

Interaction Score: 5.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPOETIN ALFA IL1R1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16337691

Sources:
NCI
GENISTEIN IL1R1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10400830

Sources:
NCI
ALCOHOL IL1R1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16272348

Sources:
NCI

Ensembl: ENSG00000115594
- Version: 101_38
Alternate Names:

IL1R1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P14778
- Version: January-2014
Alternate Names:

IL1R1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
TEND: P14778
- Version: 01-August-2011
Alternate Names:

ENSG00000115594 Ensembl Gene Id

3554 Entrez Gene Id

P14778 Uniprot Accession

Gene Info:

Target Subclass IG

Target Subclass CytokineR

Target Subclass Type1

Publications:

NCI: IL1R1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Haq et al., 1998, Role of IL-1 in renal ischemic reperfusion injury., J. Am. Soc. Nephrol.

Takii et al., 1999, Tyrosine kinase is essential for the constitutive expression of type I interleukin-1 receptor in human fibroblast cells., Eur. Cytokine Netw.

Khoruts et al., 2004, IL-1 acts on antigen-presenting cells to enhance the in vivo proliferation of antigen-stimulated naive CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands., Eur. J. Immunol.

HingoraniCasas: ENSG00000115594
- Version: 31-May-2017
Alternate Names:

ENSG00000115594 Gene Symbol

IL1R1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IL1R
- Version: chembl_23
Alternate Names:

p80 UNIPROT

IL1RA GENE_SYMBOL

IL1RT1 GENE_SYMBOL

Gene Info:

Publications:
GO: IL1R1
- Version: 01-February-2022
Alternate Names:

IL1R GO Gene Synonym

IL1RA GO Gene Synonym

IL1RT1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Interleukin 1 receptor type 1
- Version: 2020.06.01
Alternate Names:

IL1R1 TTD Gene Abbreviation

T72515 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Interleukin-1 receptor antagonist
Direct Interaction	yes
Trial Name	anakinra,Kineret

ENSG00000115594	Ensembl Gene Id
3554	Entrez Gene Id
P14778	Uniprot Accession

IL1R	GO Gene Synonym
IL1RA	GO Gene Synonym
IL1RT1	GO Gene Synonym

antagonist (inhibitory)
inhibitor (inhibitory)

p80	UNIPROT
IL1RA	GENE_SYMBOL
IL1RT1	GENE_SYMBOL

IL1R1 Gene Record

IL1R1 3554 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

ANAKINRA IL1R1

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-1 receptor antagonist Direct Interaction yes Trial Name anakinra,Kineret

PMIDs: 10210771 17352828 17083033 11752352 17498496 12355453 12817089 9555664

Sources: TdgClinicalTrial ChemblInteractions NCI TEND TTD

AMMONIUM TRICHLOROTELLURATE IL1R1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7539780

Sources: NCI

AMG-108 IL1R1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-1 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

EPOETIN ALFA IL1R1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16337691

Sources: NCI

GENISTEIN IL1R1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10400830

Sources: NCI

ALCOHOL IL1R1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16272348

Sources: NCI

Ensembl: ENSG00000115594

Alternate Names: IL1R1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P14778

Alternate Names: IL1R1 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

TEND: P14778

Alternate Names: ENSG00000115594 Ensembl Gene Id 3554 Entrez Gene Id P14778 Uniprot Accession

Gene Info: Target Subclass IG Target Subclass CytokineR Target Subclass Type1

Publications:

NCI: IL1R1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000115594

Alternate Names: ENSG00000115594 Gene Symbol IL1R1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: IL1R

Alternate Names: p80 UNIPROT IL1RA GENE_SYMBOL IL1RT1 GENE_SYMBOL

Gene Info:

Publications:

GO: IL1R1

Alternate Names: IL1R GO Gene Synonym IL1RA GO Gene Synonym IL1RT1 GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Interleukin 1 receptor type 1

Alternate Names: IL1R1 TTD Gene Abbreviation T72515 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 receptor antagonist

Direct Interaction yes

Trial Name anakinra,Kineret

PMIDs:
10210771 17352828 17083033 11752352 17498496 12355453 12817089 9555664

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
7539780

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16337691

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10400830

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16272348

Sources:
NCI

Alternate Names:

IL1R1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

IL1R1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

ENSG00000115594 Ensembl Gene Id

3554 Entrez Gene Id

P14778 Uniprot Accession

Gene Info:

Target Subclass IG

Target Subclass CytokineR

Target Subclass Type1

Alternate Names:

ENSG00000115594 Gene Symbol

IL1R1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

p80 UNIPROT

IL1RA GENE_SYMBOL

IL1RT1 GENE_SYMBOL

Alternate Names:

IL1R GO Gene Synonym

IL1RA GO Gene Synonym

IL1RT1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

IL1R1 TTD Gene Abbreviation

T72515 TTD Target ID