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IL6 Gene Record

  • Summary
  • Interactions
  • Claims
  • IL6 3569 Druggable GenomeDrug Resistance

    Alternate Names:

    3569
    INTERLEUKIN 6
    IL6
    BSF-2
    BSF2
    CDF
    HGF
    HSF
    IFN-beta-2
    IFNB2
    IL-6
    147620
    6018
    ENSG00000136244
    OTTHUMG00000023178
    Interferon beta-2
    Interleukin-6
    B-cell stimulatory factor 2
    CTL differentiation factor
    Hybridoma growth factor
    P05231
    PA198
    T32578
    2970

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUG RESISTANCE
    DRUGGABLE GENOME

    Publications:

    Epeldegui M et al., 2016, Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial)., Clin Cancer Res
    Krehmeier et al., 2002, Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells., J. Infect. Chemother.
    Heits et al., 1997, Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy-induced thrombocytopenia., Eur. J. Haematol.
    Burger et al., 1997, Echinacea-induced cytokine production by human macrophages., Int. J. Immunopharmacol.
    Genovese MC et al., 2014, Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study., Ann Rheum Dis
    van Zaanen et al., 1996, Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop., J. Clin. Invest.
    Baltch et al., 2003, Levofloxacin kills Chlamydia pneumoniae and modulates interleukin 6 production by HEp-2 cells., Chemotherapy
    Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
    Irish et al., 1996, The effects of gemfibrozil upon the hypercoagulable state in dyslipidaemic patients with chronic renal failure., Nephrol. Dial. Transplant.
    Danin et al., 2003, Cytokines in periradicular lesions: the effect of linezolid treatment., Oral Surg Oral Med Oral Pathol Oral Radiol Endod
    Esteve et al., 2007, Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity., Diabetes Care
    Equils et al., 2004, Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation., Antimicrob. Agents Chemother.
    Dávila-Fajardo CL et al., 2014, Confirmation of -174G/C interleukin-6 gene promoter polymorphism as a genetic marker predicting antitumor necrosis factor treatment outcome., Pharmacogenet Genomics
    Potaczek DP et al., 2006, Interleukin-6 -174 G/C promoter polymorphism and effects of fenofibrate and simvastatin on inflammatory markers in hypercholesterolemic patients., Blood Coagul Fibrinolysis
    Suchi K et al., 2011, Overexpression of Interleukin-6 suppresses cisplatin-induced cytotoxicity in esophageal squamous cell carcinoma cells., Anticancer Res
  • SILTUXIMAB   IL6

    Interaction Score: 9.89

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Interleukin-6 inhibitor

    PMIDs:
    8823310


    Sources:
    MyCancerGenome ChemblInteractions TTD

  • OLOKIZUMAB   IL6

    Interaction Score: 9.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CDP6038
    Novel drug target Novel Target
    Mechanism of Interaction Interleukin-6 inhibitor

    PMIDs:
    24641941


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • CLAZAKIZUMAB   IL6

    Interaction Score: 7.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-6 inhibitor
    Direct Interaction yes
    Trial Name ALD518, BMS-945429

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • COR-001   IL6

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PF-04236921   IL6

    Interaction Score: 2.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ELSILIMOMAB   IL6

    Interaction Score: 2.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SIRUKUMAB   IL6

    Interaction Score: 2.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-6 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • LEVOFLOXACIN   IL6

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12714806


    Sources:
    NCI

  • ECHINACEA, UNSPECIFIED   IL6

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9568541


    Sources:
    NCI

  • METRONIDAZOLE   IL6

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12111578


    Sources:
    NCI

  • LINEZOLID   IL6

    Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14561977


    Sources:
    NCI

  • NELFINAVIR   IL6

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15388451


    Sources:
    NCI

  • SAQUINAVIR   IL6

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15388451


    Sources:
    NCI

  • IFOSFAMIDE   IL6

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9260581


    Sources:
    NCI

  • GEMFIBROZIL   IL6

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8941582


    Sources:
    NCI

  • RITUXIMAB   IL6

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26384320


    Sources:
    PharmGKB

  • IBUDILAST   IL6

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ADALIMUMAB   IL6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24253594


    Sources:
    PharmGKB

  • ETANERCEPT   IL6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24253594


    Sources:
    PharmGKB

  • INFLIXIMAB   IL6

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24253594


    Sources:
    PharmGKB

  • FENTANYL   IL6

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9527747


    Sources:
    NCI

  • FENOFIBRATE   IL6

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16607077


    Sources:
    PharmGKB

  • INSULIN   IL6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17392554


    Sources:
    NCI

  • RIBAVIRIN   IL6

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CISPLATIN   IL6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21273582


    Sources:
    CIViC

  • Ensembl: ENSG00000136244

    • Version: 101_38

    Alternate Names:
    IL6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P05231

    • Version: January-2014

    Alternate Names:
    IL6 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine

    Publications:

  • PharmGKB: IL6

    • Version: 18-August-2020

    Alternate Names:
    PA198 PharmGKB ID

    Gene Info:

    Publications:
    Epeldegui M et al., 2016, Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial)., Clin Cancer Res
    Dávila-Fajardo CL et al., 2014, Confirmation of -174G/C interleukin-6 gene promoter polymorphism as a genetic marker predicting antitumor necrosis factor treatment outcome., Pharmacogenet Genomics
    Bank S et al., 2014, Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease., Pharmacogenomics J

  • CIViC: IL6

    • Version: 14-September-2020

    Alternate Names:
    3569 Entrez Gene ID
    2970 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Suchi K et al., 2011, Overexpression of Interleukin-6 suppresses cisplatin-induced cytotoxicity in esophageal squamous cell carcinoma cells., Anticancer Res

  • TTD: Interleukin-6

    • Version: 2020.06.01

    Alternate Names:
    IL6 TTD Gene Abbreviation
    T32578 TTD Target ID

    Gene Info:

    Publications:
    Fulciniti M et al., 2009, A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma., Clin Cancer Res
    Genovese MC et al., 2014, Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study., Ann Rheum Dis

  • NCI: IL6

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Krehmeier et al., 2002, Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells., J. Infect. Chemother.
    Burger et al., 1997, Echinacea-induced cytokine production by human macrophages., Int. J. Immunopharmacol.
    Danin et al., 2003, Cytokines in periradicular lesions: the effect of linezolid treatment., Oral Surg Oral Med Oral Pathol Oral Radiol Endod

  • HingoraniCasas: ENSG00000136244

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000136244 Gene Symbol
    IL6 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: IL6

    • Version: 20-Jun-2017

    Alternate Names:
    3569 Entrez Gene Id
    IL6 MyCancerGenome Gene Symbol
    IL-6 MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: IFNB2

    • Version: chembl_23

    Alternate Names:
    CTL differentiation factor UNIPROT
    IFNB2 GENE_SYMBOL
    IL6 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: IL6

    • Version: 01-February-2022

    Alternate Names:
    IFNB2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21