DGIdb - IL6 Gene Record

IL6 3569 Druggable GenomeDrug Resistance

Alternate Names:

3569
INTERLEUKIN 6
IL6
BSF-2
BSF2
CDF
HGF
HSF
IFN-beta-2
IFNB2
IL-6
147620
6018
ENSG00000136244
OTTHUMG00000023178
Interferon beta-2
Interleukin-6
B-cell stimulatory factor 2
CTL differentiation factor
Hybridoma growth factor
P05231
PA198
T32578
2970

Gene Info:

Target Class	Miscellaneous
Target Subclass	Ligand
Target Subclass	Cytokine
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Epeldegui M et al., 2016, Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial)., Clin Cancer Res
Krehmeier et al., 2002, Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells., J. Infect. Chemother.
Heits et al., 1997, Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy-induced thrombocytopenia., Eur. J. Haematol.
Burger et al., 1997, Echinacea-induced cytokine production by human macrophages., Int. J. Immunopharmacol.
Genovese MC et al., 2014, Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study., Ann Rheum Dis
van Zaanen et al., 1996, Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop., J. Clin. Invest.
Baltch et al., 2003, Levofloxacin kills Chlamydia pneumoniae and modulates interleukin 6 production by HEp-2 cells., Chemotherapy
Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
Irish et al., 1996, The effects of gemfibrozil upon the hypercoagulable state in dyslipidaemic patients with chronic renal failure., Nephrol. Dial. Transplant.
Danin et al., 2003, Cytokines in periradicular lesions: the effect of linezolid treatment., Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Esteve et al., 2007, Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity., Diabetes Care
Equils et al., 2004, Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation., Antimicrob. Agents Chemother.
Dávila-Fajardo CL et al., 2014, Confirmation of -174G/C interleukin-6 gene promoter polymorphism as a genetic marker predicting antitumor necrosis factor treatment outcome., Pharmacogenet Genomics
Potaczek DP et al., 2006, Interleukin-6 -174 G/C promoter polymorphism and effects of fenofibrate and simvastatin on inflammatory markers in hypercholesterolemic patients., Blood Coagul Fibrinolysis
Suchi K et al., 2011, Overexpression of Interleukin-6 suppresses cisplatin-induced cytotoxicity in esophageal squamous cell carcinoma cells., Anticancer Res

SILTUXIMAB IL6

Interaction Score: 9.89

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-6 inhibitor

PMIDs:
8823310

Sources:
MyCancerGenome ChemblInteractions TTD
OLOKIZUMAB IL6

Interaction Score: 9.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CDP6038

Novel drug target Novel Target

Mechanism of Interaction Interleukin-6 inhibitor

PMIDs:
24641941

Sources:
TdgClinicalTrial ChemblInteractions TTD
CLAZAKIZUMAB IL6

Interaction Score: 7.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

Trial Name ALD518, BMS-945429

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
COR-001 IL6

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PF-04236921 IL6

Interaction Score: 2.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ELSILIMOMAB IL6

Interaction Score: 2.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SIRUKUMAB IL6

Interaction Score: 2.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
LEVOFLOXACIN IL6

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12714806

Sources:
NCI
ECHINACEA, UNSPECIFIED IL6

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9568541

Sources:
NCI
METRONIDAZOLE IL6

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12111578

Sources:
NCI
LINEZOLID IL6

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14561977

Sources:
NCI
NELFINAVIR IL6

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
SAQUINAVIR IL6

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
IFOSFAMIDE IL6

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9260581

Sources:
NCI
GEMFIBROZIL IL6

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8941582

Sources:
NCI
RITUXIMAB IL6

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26384320

Sources:
PharmGKB
IBUDILAST IL6

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ADALIMUMAB IL6

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24253594

Sources:
PharmGKB
ETANERCEPT IL6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24253594

Sources:
PharmGKB
INFLIXIMAB IL6

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24253594

Sources:
PharmGKB
FENTANYL IL6

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9527747

Sources:
NCI
FENOFIBRATE IL6

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16607077

Sources:
PharmGKB
INSULIN IL6

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17392554

Sources:
NCI
RIBAVIRIN IL6

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CISPLATIN IL6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21273582

Sources:
CIViC

Ensembl: ENSG00000136244
- Version: 101_38
Alternate Names:

IL6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P05231
- Version: January-2014
Alternate Names:

IL6 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Cytokine

Publications:

PharmGKB: IL6

Version: 18-August-2020

Alternate Names:

PA198 PharmGKB ID

Gene Info:

Publications:

Epeldegui M et al., 2016, Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial)., Clin Cancer Res

Dávila-Fajardo CL et al., 2014, Confirmation of -174G/C interleukin-6 gene promoter polymorphism as a genetic marker predicting antitumor necrosis factor treatment outcome., Pharmacogenet Genomics

Bank S et al., 2014, Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease., Pharmacogenomics J

CIViC: IL6
- Version: 14-September-2020
Alternate Names:

3569 Entrez Gene ID

2970 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Suchi K et al., 2011, Overexpression of Interleukin-6 suppresses cisplatin-induced cytotoxicity in esophageal squamous cell carcinoma cells., Anticancer Res

TTD: Interleukin-6

Version: 2020.06.01

Alternate Names:

IL6 TTD Gene Abbreviation

T32578 TTD Target ID

Gene Info:

Publications:

Fulciniti M et al., 2009, A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma., Clin Cancer Res

Genovese MC et al., 2014, Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study., Ann Rheum Dis

NCI: IL6

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Krehmeier et al., 2002, Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells., J. Infect. Chemother.

Burger et al., 1997, Echinacea-induced cytokine production by human macrophages., Int. J. Immunopharmacol.

Danin et al., 2003, Cytokines in periradicular lesions: the effect of linezolid treatment., Oral Surg Oral Med Oral Pathol Oral Radiol Endod

HingoraniCasas: ENSG00000136244
- Version: 31-May-2017
Alternate Names:

ENSG00000136244 Gene Symbol

IL6 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: IL6
- Version: 20-Jun-2017
Alternate Names:

3569 Entrez Gene Id

IL6 MyCancerGenome Gene Symbol

IL-6 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: IFNB2
- Version: chembl_23
Alternate Names:

CTL differentiation factor UNIPROT

IFNB2 GENE_SYMBOL

IL6 GENE_SYMBOL

Gene Info:

Publications:
GO: IL6
- Version: 01-February-2022
Alternate Names:

IFNB2 GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	Interleukin-6 inhibitor

Trial Name	CDP6038
Novel drug target	Novel Target
Mechanism of Interaction	Interleukin-6 inhibitor

3569	Entrez Gene Id
IL6	MyCancerGenome Gene Symbol
IL-6	MyCancerGenome Reported Gene Name

CTL differentiation factor	UNIPROT
IFNB2	GENE_SYMBOL
IL6	GENE_SYMBOL

antibody (inhibitory)
antagonist (inhibitory)
inhibitor (inhibitory)

IL6 Gene Record

IL6 3569 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Interleukin-6 inhibitor

PMIDs: 8823310

Sources: MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CDP6038 Novel drug target Novel Target Mechanism of Interaction Interleukin-6 inhibitor

PMIDs: 24641941

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-6 inhibitor Direct Interaction yes Trial Name ALD518, BMS-945429

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-6 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-6 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-6 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12714806

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9568541

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12111578

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14561977

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9260581

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8941582

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26384320

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24253594

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-6 inhibitor

PMIDs:
8823310

Sources:
MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CDP6038

Novel drug target Novel Target

Mechanism of Interaction Interleukin-6 inhibitor

PMIDs:
24641941

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

Trial Name ALD518, BMS-945429

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
12714806

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9568541

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12111578

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14561977

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9260581

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8941582

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26384320

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
24253594

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24253594

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24253594

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9527747

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16607077

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17392554

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21273582