DGIdb - IRS1 Gene Record

IRS1 3667 Clinically Actionable

Alternate Names:

3667
INSULIN RECEPTOR SUBSTRATE 1
IRS1
HIRS-1
147545
6125
ENSG00000169047
OTTHUMG00000133179
P35568
BE0000977
PA203

Gene Info:

Target Class	Receptors
Target Subclass	Insulin receptor substrate
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

KINASE
CLINICALLY ACTIONABLE

Publications:

Müller et al., 2005, Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes., Biochem. Pharmacol.
Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.
Takeuchi et al., 1998, PTB domain of insulin receptor substrate-1 binds inositol compounds., Biochem. J.
Resnicoff et al., 1994, Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells., Lab. Invest.

GLIMEPIRIDE IRS1

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15710354

Sources:
NCI
INOSITOL IRS1

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9693122

Sources:
NCI
PRASTERONE IRS1

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15501480

Sources:
NCI
EPIRUBICIN IRS1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ALCOHOL IRS1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7526037

Sources:
NCI
CYCLOPHOSPHAMIDE IRS1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUOROURACIL IRS1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000169047
- Version: 101_38
Alternate Names:

IRS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P35568
- Version: January-2014
Alternate Names:

IRS1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Insulin receptor substrate

Publications:
DrugBank: BE0000977
- Version: 5.1.7
Alternate Names:

IRS1 DrugBank Gene Name

P35568 UniProt Accession

3667 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: IRS1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Takeuchi et al., 1998, PTB domain of insulin receptor substrate-1 binds inositol compounds., Biochem. J.

Resnicoff et al., 1994, Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells., Lab. Invest.

Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.

PharmGKB: IRS1
- Version: 18-August-2020
Alternate Names:

PA203 PharmGKB ID

Gene Info:

Publications:
Pharos: IRS1
- Version: 03-September-2020
Alternate Names:

Insulin receptor substrate 1 Gene Name

P35568 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: IRS1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

IRS1	DrugBank Gene Name
P35568	UniProt Accession
3667	Entrez Gene Id

IRS1 Gene Record

IRS1 3667 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

GLIMEPIRIDE IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15710354

Sources: NCI

INOSITOL IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9693122

Sources: NCI

PRASTERONE IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15501480

Sources: NCI

EPIRUBICIN IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ALCOHOL IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7526037

Sources: NCI

CYCLOPHOSPHAMIDE IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

FLUOROURACIL IRS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000169047

Alternate Names: IRS1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P35568

Alternate Names: IRS1 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Insulin receptor substrate

Publications:

DrugBank: BE0000977

Alternate Names: IRS1 DrugBank Gene Name P35568 UniProt Accession 3667 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: IRS1

Alternate Names:

Gene Info:

PharmGKB: IRS1

Alternate Names: PA203 PharmGKB ID

Gene Info:

Publications:

Pharos: IRS1

Alternate Names: Insulin receptor substrate 1 Gene Name P35568 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

MskImpact: IRS1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
15710354

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9693122

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15501480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7526037

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

IRS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

IRS1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Insulin receptor substrate

Alternate Names:

IRS1 DrugBank Gene Name

P35568 UniProt Accession

3667 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Alternate Names:

PA203 PharmGKB ID

Alternate Names:

Insulin receptor substrate 1 Gene Name

P35568 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE