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IRS1 Gene Record

  • Summary
  • Interactions
  • Claims
  • IRS1 3667 Clinically Actionable

    Alternate Names:

    3667
    INSULIN RECEPTOR SUBSTRATE 1
    IRS1
    HIRS-1
    147545
    6125
    ENSG00000169047
    OTTHUMG00000133179
    P35568
    PA203

    Gene Info:

    Target Class Receptors
    Target Subclass Insulin receptor substrate
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    KINASE
    CLINICALLY ACTIONABLE

    Publications:

    Müller et al., 2005, Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes., Biochem. Pharmacol.
    Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.
    Takeuchi et al., 1998, PTB domain of insulin receptor substrate-1 binds inositol compounds., Biochem. J.
    Resnicoff et al., 1994, Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells., Lab. Invest.
  • GLIMEPIRIDE   IRS1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15710354


    Sources:
    NCI

  • INOSITOL   IRS1

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9693122


    Sources:
    NCI

  • PRASTERONE   IRS1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15501480


    Sources:
    NCI

  • EPIRUBICIN   IRS1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   IRS1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7526037


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   IRS1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUOROURACIL   IRS1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000169047

    • Version: 101_38

    Alternate Names:
    IRS1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P35568

    • Version: January-2014

    Alternate Names:
    IRS1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Insulin receptor substrate

    Publications:

  • NCI: IRS1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Takeuchi et al., 1998, PTB domain of insulin receptor substrate-1 binds inositol compounds., Biochem. J.
    Resnicoff et al., 1994, Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells., Lab. Invest.
    Campbell et al., 2004, The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo., Life Sci.

  • PharmGKB: IRS1

    • Version: 18-August-2020

    Alternate Names:
    PA203 PharmGKB ID

    Gene Info:

    Publications:

  • Pharos: IRS1

    • Version: 01-February-2022

    Alternate Names:
    Insulin receptor substrate 1 Gene Name
    P35568 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: IRS1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21