DGIdb - IRS2 Gene Record

IRS2 8660 Clinically Actionable

Alternate Names:

8660
INSULIN RECEPTOR SUBSTRATE 2
IRS2
IRS-2
600797
6126
ENSG00000185950
OTTHUMG00000017338
6862
Q9Y4H2

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
CLINICALLY ACTIONABLE

Publications:

Caperuto et al., 2006, Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats., Endocrine
Slattery et al., 2008, Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions., Int. J. Cancer
Anai et al., 1998, Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats., Diabetes
Villuendas et al., 2005, Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls., Hum. Reprod.
Lautier et al., 2003, Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation., Hum. Genet.
El Mkadem et al., 2001, Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome., Diabetes

INSULIN IRS2

Interaction Score: 2.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9421369 16037106 12687350 11522686

Sources:
NCI
ASPIRIN IRS2

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18059035

Sources:
NCI
DEXAMETHASONE IRS2

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16943575

Sources:
NCI

Ensembl: ENSG00000185950
- Version: 101_38
Alternate Names:

IRS2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: IRS2

Version: 14-September-2020

Alternate Names:

8660 Entrez Gene ID

6862 CIViC Gene ID

Gene Info:

Publications:

Huang F et al., 2015, IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines., Mol Cancer Ther

NCI: IRS2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

El Mkadem et al., 2001, Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome., Diabetes

Anai et al., 1998, Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats., Diabetes

Villuendas et al., 2005, Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls., Hum. Reprod.

Tempus: IRS2
- Version: 11-November-2018
Alternate Names:

IRS2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: IRS2
- Version: 01-February-2022
Alternate Names:

Insulin receptor substrate 2 Gene Name

Q9Y4H2 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: IRS2
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: IRS2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: IRS2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Insulin receptor substrate 2	Gene Name
Q9Y4H2	UniProt ID

IRS2 Gene Record

IRS2 8660 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

INSULIN IRS2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9421369 16037106 12687350 11522686

Sources: NCI

ASPIRIN IRS2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18059035

Sources: NCI

DEXAMETHASONE IRS2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16943575

Sources: NCI

Ensembl: ENSG00000185950

Alternate Names: IRS2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: IRS2

Alternate Names: 8660 Entrez Gene ID 6862 CIViC Gene ID

Gene Info:

Publications: Huang F et al., 2015, IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines., Mol Cancer Ther

NCI: IRS2

Alternate Names:

Gene Info:

Tempus: IRS2

Alternate Names: IRS2 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: IRS2

Alternate Names: Insulin receptor substrate 2 Gene Name Q9Y4H2 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

MskImpact: IRS2

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: IRS2

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: IRS2

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
9421369 16037106 12687350 11522686

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18059035

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16943575

Sources:
NCI

Alternate Names:

IRS2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

8660 Entrez Gene ID

6862 CIViC Gene ID

Publications:

Huang F et al., 2015, IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines., Mol Cancer Ther

Alternate Names:

IRS2 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Insulin receptor substrate 2 Gene Name

Q9Y4H2 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE