• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

IRS2 Gene Record

  • Summary
  • Interactions
  • Claims
  • IRS2 8660 Clinically Actionable

    Alternate Names:

    8660
    INSULIN RECEPTOR SUBSTRATE 2
    IRS2
    IRS-2
    600797
    6126
    ENSG00000185950
    OTTHUMG00000017338
    6862
    Q9Y4H2

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    KINASE
    CLINICALLY ACTIONABLE

    Publications:

    Caperuto et al., 2006, Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats., Endocrine
    Slattery et al., 2008, Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions., Int. J. Cancer
    Anai et al., 1998, Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats., Diabetes
    Villuendas et al., 2005, Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls., Hum. Reprod.
    Lautier et al., 2003, Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation., Hum. Genet.
    El Mkadem et al., 2001, Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome., Diabetes
  • INSULIN   IRS2

    Interaction Score: 2.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9421369 16037106 12687350 11522686


    Sources:
    NCI

  • ASPIRIN   IRS2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18059035


    Sources:
    NCI

  • DEXAMETHASONE   IRS2

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16943575


    Sources:
    NCI

  • Ensembl: ENSG00000185950

    • Version: 101_38

    Alternate Names:
    IRS2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: IRS2

    • Version: 14-September-2020

    Alternate Names:
    8660 Entrez Gene ID
    6862 CIViC Gene ID

    Gene Info:

    Publications:
    Huang F et al., 2015, IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines., Mol Cancer Ther

  • NCI: IRS2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    El Mkadem et al., 2001, Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome., Diabetes
    Anai et al., 1998, Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats., Diabetes
    Villuendas et al., 2005, Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls., Hum. Reprod.

  • Tempus: IRS2

    • Version: 11-November-2018

    Alternate Names:
    IRS2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: IRS2

    • Version: 01-February-2022

    Alternate Names:
    Insulin receptor substrate 2 Gene Name
    Q9Y4H2 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: IRS2

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: IRS2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: IRS2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21