• Interaction Score: 7.1

    Interaction Types & Directionality:
    antagonist (inhibitory)
    antibody (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-5/beta-1 antagonist
    Direct Interaction yes
    Details of the Assay for Interaction Binding affinity to human α5β1-Fc, determined using BIAcore SPR technology.

    PMIDs:
    None found


  • Interaction Score: 3.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11061591


    Sources:
    NCI

  • Interaction Score: 3.55

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Notes Targets ALPHA-5/BETA-1 INTEGRIN

    PMIDs:
    None found


    Sources:
    TALC

  • Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9678720


    Sources:
    NCI

  • Interaction Score: 1.78

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Notes Targets ALPHA-5/BETA-1 INTEGRIN

    PMIDs:
    None found


    Sources:
    TALC

  • Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name cilengitide. EMD-121974
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name GLPG0187

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23943159


    Sources:
    DrugBank