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ITGAL 3683 Druggable Genome
Alternate Names:
3683 INTEGRIN SUBUNIT ALPHA L ITGAL CD11A LFA-1 LFA1A 153370 6148 ENSG00000005844 OTTHUMG00000176964 P20701 Integrin alpha-L CD11 antigen-like family member A LFA-1A CD_antigen=CD11a Leukocyte adhesion glycoprotein LFA-1 alpha chain Leukocyte function-associated molecule 1 alpha chain INTEGRIN ALPHA-L PRECURSOR (LEUKOCYTE ADHESION GLYCOPROTEIN LFA-1 ALPHA CHAIN) (LFA-1A) (LEUKOCYTE FUNCTION ASSOCIATED MOLECULE 1, ALPHA CHAIN) (CD11A). [SOURCE:UNIPROT/SWISSPROT;ACC:P20701] ITAL_HUMAN T35640 Gene Info:
Human Readable Name DRUGGABLE GENOME Target Subclass Integrin Target Subclass Other_receptors Target Main Class Receptors Transmembrane Helix Count 1 Target Class Receptors Target Subclass Receptors Uniprot Status Swiss-Prot Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR000413 Interpro Type Family Interpro Short Name Integrin_alpha Interpro Name Integrin alpha chain Gene Biotype PROTEIN_CODING Gene Categories: Category Details
CELL SURFACE EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME Publications:
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Interaction Score: 14.55
Interaction Types & Directionality:
antibody (inhibitory) inhibitor (inhibitory) Interaction Info:
Novel drug target Established target Trial Name Raptiva Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) inhibitor -
Interaction Score: 7.27
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Interaction Score: 7.27
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Interaction Score: 7.27
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Interaction Score: 3.64
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Leukocyte adhesion glycoprotein LFA-1 alpha inhibitor Direct Interaction yes -
Interaction Score: 3.64
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) antagonist Direct Interaction yes -
Interaction Score: 1.21
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Interaction Score: 1.21
Interaction Types & Directionality:
antibody (inhibitory) antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) antagonist Direct Interaction yes -
Interaction Score: 0.38
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Interaction Score: 0.27
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Interaction Score: 0.18
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Interaction Score: 0.09
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Interaction Score: 0.07
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- Version: 101_38
Alternate Names:
ITGAL Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 26-July-2011
Alternate Names:
INTEGRIN ALPHA-L PRECURSOR (LEUKOCYTE ADHESION GLYCOPROTEIN LFA-1 ALPHA CHAIN) (LFA-1A) (LEUKOCYTE FUNCTION ASSOCIATED MOLECULE 1, ALPHA CHAIN) (CD11A). [SOURCE:UNIPROT/SWISSPROT;ACC:P20701] Description ENSG00000005844 Ensembl Gene Id ITGAL Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
ITGAL Gene Symbol Gene Info:
Target Class Receptors Target Subclass Receptors Target Subclass Integrin Publications:
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- Version: 11-September-2012
Alternate Names:
3683 Entrez Gene Id ENSG00000005844 Ensembl Gene Id ITGAL Uniprot Gene Name Gene Info:
Uniprot Status Swiss-Prot Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR000413 Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
P20701 Uniprot Accession ENSG00000005844 Ensembl Gene Id ITGAL Gene Symbol Gene Info:
Target Subclass Other_receptors Target Main Class Receptors Target Subclass Integrin Publications:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000005844 Gene Symbol ITGAL Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
CD11A GENE_SYMBOL ITGAL GENE_SYMBOL Integrin alpha-L UNIPROT Gene Info:
Publications:
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Alternate Names:
CD11A GO Gene Synonym Gene Info:
Gene Categories:
CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE Publications:
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- Version: 2020.06.01
Alternate Names:
ITGAL TTD Gene Abbreviation T35640 TTD Target ID Gene Info:
Publications: