DGIdb - ITGAM Gene Record

ITGAM 3684 Druggable Genome

Alternate Names:

3684
INTEGRIN SUBUNIT ALPHA M
ITGAM
CD11B
CR3A
MAC-1
MAC1A
MO1A
SLEB6
120980
6149
ENSG00000169896
OTTHUMG00000176612
Leukocyte adhesion receptor MO1
Cell surface glycoprotein MAC-1 subunit alpha
CD11 antigen-like family member B
CR-3 alpha chain
CD_antigen=CD11b
Integrin alpha-M
Neutrophil adherence receptor
ITAM_HUMAN
P11215
INTEGRIN ALPHA-M PRECURSOR (CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT) (CR-3 ALPHA CHAIN) (CD11B) (LEUKOCYTE ADHESION RECEPTOR MO1) (NEUTROPHIL ADHERENCE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P11215]

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000413
Interpro Name	Integrin alpha chain
Interpro Short Name	Integrin_alpha
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Fu et al., 2005, [Different impacts of DMSO and RA on GPI-80 expression]., Shi Yan Sheng Wu Xue Bao
Diez-Fraile et al., 2000, Effect of isoproterenol and dexamethasone on the lipopolysaccharide induced expression of CD11b on bovine neutrophils., Vet. Immunol. Immunopathol.
van Pelt et al., Effects of systemic treatment with liarozole on cutaneous inflammation, epidermal proliferation and differentiation in extensive plaque psoriasis., Skin Pharmacol. Appl. Skin Physiol.
Enomoto et al., 2002, Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis., Auris Nasus Larynx
Sun et al., 2007, Beneficial effects of hydrocortisone in induced acute pancreatitis of rats., Chin. Med. J.
Menzebach et al., 2004, [Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependent mechanism]., Anasthesiol Intensivmed Notfallmed Schmerzther
Dobreanu et al., 2007, Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin., Rom J Intern Med
Spoelstra et al., 1998, Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro., Eur. Respir. J.

LIAROZOLE ITGAM

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9603657

Sources:
NCI
ROVELIZUMAB ITGAM

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-M/beta-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIMETHYL SULFOXIDE ITGAM

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15839205

Sources:
NCI
CLARITHROMYCIN ITGAM

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12167449

Sources:
NCI
PHENYLEPHRINE ITGAM

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10973693

Sources:
NCI
THEOPHYLLINE ITGAM

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9762784

Sources:
NCI
FENTANYL ITGAM

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15098168

Sources:
NCI
MORPHINE ITGAM

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15098168

Sources:
NCI
HYDROCORTISONE ITGAM

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18028766

Sources:
NCI
ATORVASTATIN ITGAM

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18333374

Sources:
NCI

Ensembl: ENSG00000169896
- Version: 101_38
Alternate Names:

ITGAM Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000169896

Version: 26-July-2011

Alternate Names:

INTEGRIN ALPHA-M PRECURSOR (CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT) (CR-3 ALPHA CHAIN) (CD11B) (LEUKOCYTE ADHESION RECEPTOR MO1) (NEUTROPHIL ADHERENCE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P11215] Description

ENSG00000169896 Ensembl Gene Id

ITGAM Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P11215
- Version: 11-September-2012
Alternate Names:

3684 Entrez Gene Id

ENSG00000169896 Ensembl Gene Id

ITAM_HUMAN Uniprot Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Acc IPR000413

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: ITGAM

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Enomoto et al., 2002, Effect of new macrolides on the expression of adhesion molecules on neutrophils in chronic sinusitis., Auris Nasus Larynx

Sun et al., 2007, Beneficial effects of hydrocortisone in induced acute pancreatitis of rats., Chin. Med. J.

He et al., 2001, Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum., Brain Res.

HingoraniCasas: ENSG00000169896
- Version: 31-May-2017
Alternate Names:

ENSG00000169896 Gene Symbol

ITGAM Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CD11B
- Version: chembl_23
Alternate Names:

CR3A GENE_SYMBOL

ITGAM GENE_SYMBOL

Integrin alpha-M UNIPROT

Gene Info:

Publications:
GO: ITGAM
- Version: 01-February-2022
Alternate Names:

CD11B GO Gene Synonym

CR3A GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Mechanism of Interaction	Integrin alpha-M/beta-2 antagonist
Direct Interaction	yes

INTEGRIN ALPHA-M PRECURSOR (CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT) (CR-3 ALPHA CHAIN) (CD11B) (LEUKOCYTE ADHESION RECEPTOR MO1) (NEUTROPHIL ADHERENCE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P11215]	Description
ENSG00000169896	Ensembl Gene Id
ITGAM	Display Id

3684	Entrez Gene Id
ENSG00000169896	Ensembl Gene Id
ITAM_HUMAN	Uniprot Id

ITGAM Gene Record

ITGAM 3684 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9603657

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-M/beta-2 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15839205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12167449

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10973693

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9762784

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15098168

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15098168

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18028766

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18333374

Sources: NCI

Ensembl: ENSG00000169896

Alternate Names: ITGAM Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000169896

Alternate Names: INTEGRIN ALPHA-M PRECURSOR (CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT) (CR-3 ALPHA CHAIN) (CD11B) (LEUKOCYTE ADHESION RECEPTOR MO1) (NEUTROPHIL ADHERENCE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P11215] Description ENSG00000169896 Ensembl Gene Id ITGAM Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P11215

Alternate Names: 3684 Entrez Gene Id ENSG00000169896 Ensembl Gene Id ITAM_HUMAN Uniprot Id

Gene Info: Human Readable Name DRUGGABLE GENOME Uniprot Status Swiss-Prot Interpro Acc IPR000413

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: ITGAM

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000169896

Alternate Names: ENSG00000169896 Gene Symbol ITGAM Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: CD11B

Alternate Names: CR3A GENE_SYMBOL ITGAM GENE_SYMBOL Integrin alpha-M UNIPROT

Gene Info:

Publications:

GO: ITGAM

Alternate Names: CD11B GO Gene Synonym CR3A GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
9603657

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-M/beta-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15839205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12167449

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10973693

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9762784

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15098168

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15098168

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18028766

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18333374

Sources:
NCI

Alternate Names:

ITGAM Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

INTEGRIN ALPHA-M PRECURSOR (CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT) (CR-3 ALPHA CHAIN) (CD11B) (LEUKOCYTE ADHESION RECEPTOR MO1) (NEUTROPHIL ADHERENCE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P11215] Description

ENSG00000169896 Ensembl Gene Id

ITGAM Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3684 Entrez Gene Id

ENSG00000169896 Ensembl Gene Id

ITAM_HUMAN Uniprot Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Acc IPR000413

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000169896 Gene Symbol

ITGAM Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CR3A GENE_SYMBOL

ITGAM GENE_SYMBOL

Integrin alpha-M UNIPROT

Alternate Names:

CD11B GO Gene Synonym

CR3A GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE