DGIdb - ITGB2 Gene Record

ITGB2 3689 Druggable Genome

Alternate Names:

3689
INTEGRIN SUBUNIT BETA 2
ITGB2
CD18
LAD
LCAMB
LFA-1
MAC-1
MF17
MFI7
600065
6155
ENSG00000160255
OTTHUMG00000090257
P05107
ITB2_HUMAN
Complement receptor C3 subunit beta
CD_antigen=CD18
Integrin beta-2
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
INTEGRIN BETA-2 PRECURSOR (CELL SURFACE ADHESION GLYCOPROTEINS LFA- 1/CR3/P150,95 BETA-SUBUNIT) (CD18) (COMPLEMENT RECEPTOR C3 BETA- SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05107]
2456
integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)
NP_000202\|NP_001120963
NM_000211\|NM_001127491

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002369
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Integrin beta subunit, N-terminal
Uniprot Status	Swiss-Prot
Interpro Short Name	Integrin_bsu_N
Target Class	Receptors
Target Subclass	Receptors
Target Subclass	Integrin
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Integrins
GuideToPharmacology Gene Category ID	760

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Santos-Perez et al., 1996, T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis., Immunol. Lett.
Deitch et al., 2003, Hypertonic saline resuscitation limits neutrophil activation after trauma-hemorrhagic shock., Shock
Stadnyk et al., 2002, Neutrophil migration into indomethacin induced rat small intestinal injury is CD11a/CD18 and CD11b/CD18 co-dependent., Gut
Richter et al., 2003, Mycophenolate mofetil significantly reduces leukocyte graft infiltration after heterotopic cardiac transplantation in a rat model: comparative study with cyclosporine and FK 506., J. Heart Lung Transplant.
Lacki et al., 1997, Does cyclophosphamide combined with methylprednisolone affect the expression of leukocyte function associated antigen 1 in refractory rheumatoid arthritis., Arch. Immunol. Ther. Exp. (Warsz.)
Hbabi et al., 1993, In vitro stimulation of polymorphonuclear cell adhesion by ribomunyl and antibiotic + ribomunyl combinations: effects on CD18, CD35 and CD16 expression., Int. J. Immunopharmacol.
Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
Ciesielski et al., 1998, Effects of cyclosporine A and methotrexate on CD18 expression in recipients of rat cardiac allografts., Transpl. Immunol.
Mampaso et al., 1993, Expression of adhesion molecules in allograft renal dysfunction. A distinct diagnostic pattern in rejection and cyclosporine nephrotoxicity., Transplantation
Cronstein et al., 1995, Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils., J. Clin. Invest.
Torre et al., Effects of interleukin-8 on suppression of human lymphocyte polarization and migration by anti-LFA-1 antibody., Eur. Cytokine Netw.
Sakamaki et al., 1999, Effects of lung preservation solutions on PMN activation in vitro., Transpl. Int.
Hayashi et al., 1996, Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimental anti-glomerular basement membrane antibody-associated glomerulonephritis (3)., Eur. J. Pharmacol.
Settles et al., 2001, Down-regulation of cell adhesion molecules LFA-1 and ICAM-1 after in vitro treatment with the anti-TNF-alpha agent thalidomide., Cell. Mol. Biol. (Noisy-le-grand)

BUTEIN ITGB2

Interaction Score: 2.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8982701

Sources:
NCI
ERLIZUMAB ITGB2

Interaction Score: 2.99

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Integrin beta-2 negative modulator

PMIDs:
None found

Sources:
ChemblInteractions
MLNM-2201 ITGB2

Interaction Score: 2.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Integrin beta-2 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ROVELIZUMAB ITGB2

Interaction Score: 1.99

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Binding

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
AME-133V ITGB2

Interaction Score: 1.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin beta-2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIFITEGRAST ITGB2

Interaction Score: 1.0

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EFALIZUMAB ITGB2

Interaction Score: 1.0

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MYCOPHENOLATE MOFETIL ITGB2

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14550820

Sources:
NCI
ANTIBIOTIC ITGB2

Interaction Score: 0.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8096833

Sources:
NCI
SODIUM CHLORIDE ITGB2

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12688543

Sources:
NCI
METHYLPREDNISOLONE ITGB2

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8976974

Sources:
NCI
PREDNISONE ITGB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8976974

Sources:
NCI
COLCHICINE ITGB2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7543498 1363595

Sources:
NCI
PENTOXIFYLLINE ITGB2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10363593

Sources:
NCI
THALIDOMIDE ITGB2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11838958

Sources:
NCI
CYCLOSPORINE ITGB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9777701 8212167

Sources:
NCI
INDOMETHACIN ITGB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11950807

Sources:
NCI
CYCLOPHOSPHAMIDE ITGB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9523002

Sources:
NCI
ALCOHOL ITGB2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8803617

Sources:
NCI

Ensembl: ENSG00000160255
- Version: 101_38
Alternate Names:

ITGB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P05107
- Version: 11-September-2012
Alternate Names:

P05107 Uniprot Accession

ENSG00000160255 Ensembl Gene Id

3689 Entrez Gene Id

Gene Info:

Interpro Acc IPR002369

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P05107
- Version: January-2014
Alternate Names:

ITGB2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Integrin

Publications:

RussLampel: ENSG00000160255

Version: 26-July-2011

Alternate Names:

ENSG00000160255 Ensembl Gene Id

INTEGRIN BETA-2 PRECURSOR (CELL SURFACE ADHESION GLYCOPROTEINS LFA- 1/CR3/P150,95 BETA-SUBUNIT) (CD18) (COMPLEMENT RECEPTOR C3 BETA- SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05107] Description

ITGB2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 3689
- Version: 29-September-2020
Alternate Names:

6155 HUGO Gene ID

6155 HUGO Gene Symbol

integrin subunit beta 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Integrins

GuideToPharmacology Gene Category ID 760

Publications:

NCI: ITGB2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Santos-Perez et al., 1996, T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis., Immunol. Lett.

Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne

Green et al., 1994, T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA-1-mediated events., Eur. J. Immunol.

HingoraniCasas: ENSG00000160255
- Version: 31-May-2017
Alternate Names:

ENSG00000160255 Gene Symbol

ITGB2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CD18
- Version: chembl_23
Alternate Names:

MFI7 GENE_SYMBOL

ITGB2 GENE_SYMBOL

Integrin beta-2 UNIPROT

Gene Info:

Publications:
GO: ITGB2
- Version: 05-September-2020
Alternate Names:

CD18 GO Gene Synonym

MFI7 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Integrin beta-2 negative modulator

Direct Interaction	yes
Mechanism of Interaction	Integrin beta-2 inhibitor

Specific Action of the Ligand	Binding
Endogenous Drug?	False
Direct Interaction?	True

Mechanism of Interaction	Integrin alpha-L/beta-2 (LFA-1) antagonist
Direct Interaction	yes

Mechanism of Interaction	Integrin alpha-L/beta-2 (LFA-1) inhibitor
Direct Interaction	yes

P05107	Uniprot Accession
ENSG00000160255	Ensembl Gene Id
3689	Entrez Gene Id

6155	HUGO Gene ID
6155	HUGO Gene Symbol
integrin subunit beta 2	HUGO Gene Name

antibody (inhibitory)
antagonist (inhibitory)

ITGB2 Gene Record

ITGB2 3689 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8982701

Sources: NCI

Interaction Types & Directionality: negative modulator (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Integrin beta-2 negative modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Integrin beta-2 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Integrin beta-2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14550820

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8096833

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12688543

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8976974

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8976974

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7543498 1363595

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10363593

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11838958

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9777701 8212167

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11950807

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9523002

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
8982701

Sources:
NCI

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Integrin beta-2 negative modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Integrin beta-2 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Binding

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin beta-2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
14550820

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8096833

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12688543

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8976974

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8976974

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7543498 1363595

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10363593

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11838958

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9777701 8212167

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11950807

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9523002

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8803617

Sources:
NCI

Alternate Names:

ITGB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P05107 Uniprot Accession

ENSG00000160255 Ensembl Gene Id

3689 Entrez Gene Id

Gene Info:

Interpro Acc IPR002369

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ITGB2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Integrin

Alternate Names:

ENSG00000160255 Ensembl Gene Id

INTEGRIN BETA-2 PRECURSOR (CELL SURFACE ADHESION GLYCOPROTEINS LFA- 1/CR3/P150,95 BETA-SUBUNIT) (CD18) (COMPLEMENT RECEPTOR C3 BETA- SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05107] Description

ITGB2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

6155 HUGO Gene ID

6155 HUGO Gene Symbol

integrin subunit beta 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Integrins

GuideToPharmacology Gene Category ID 760

Alternate Names:

ENSG00000160255 Gene Symbol

ITGB2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MFI7 GENE_SYMBOL

ITGB2 GENE_SYMBOL

Integrin beta-2 UNIPROT

Alternate Names:

CD18 GO Gene Synonym

MFI7 GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE