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ITGB2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ITGB2 3689 Druggable Genome

    Alternate Names:

    3689
    INTEGRIN SUBUNIT BETA 2
    ITGB2
    CD18
    LAD
    LCAMB
    LFA-1
    MAC-1
    MF17
    MFI7
    600065
    6155
    ENSG00000160255
    OTTHUMG00000090257
    P05107
    ITB2_HUMAN
    Complement receptor C3 subunit beta
    CD_antigen=CD18
    Integrin beta-2
    Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    INTEGRIN BETA-2 PRECURSOR (CELL SURFACE ADHESION GLYCOPROTEINS LFA- 1/CR3/P150,95 BETA-SUBUNIT) (CD18) (COMPLEMENT RECEPTOR C3 BETA- SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05107]
    2456
    integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)
    NP_000202|NP_001120963
    NM_000211|NM_001127491

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002369
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Integrin beta subunit, N-terminal
    Uniprot Status Swiss-Prot
    Interpro Short Name Integrin_bsu_N
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Integrins
    GuideToPharmacology Gene Category ID 760
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Santos-Perez et al., 1996, T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis., Immunol. Lett.
    Deitch et al., 2003, Hypertonic saline resuscitation limits neutrophil activation after trauma-hemorrhagic shock., Shock
    Stadnyk et al., 2002, Neutrophil migration into indomethacin induced rat small intestinal injury is CD11a/CD18 and CD11b/CD18 co-dependent., Gut
    Richter et al., 2003, Mycophenolate mofetil significantly reduces leukocyte graft infiltration after heterotopic cardiac transplantation in a rat model: comparative study with cyclosporine and FK 506., J. Heart Lung Transplant.
    Lacki et al., 1997, Does cyclophosphamide combined with methylprednisolone affect the expression of leukocyte function associated antigen 1 in refractory rheumatoid arthritis., Arch. Immunol. Ther. Exp. (Warsz.)
    Hbabi et al., 1993, In vitro stimulation of polymorphonuclear cell adhesion by ribomunyl and antibiotic + ribomunyl combinations: effects on CD18, CD35 and CD16 expression., Int. J. Immunopharmacol.
    Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
    Ciesielski et al., 1998, Effects of cyclosporine A and methotrexate on CD18 expression in recipients of rat cardiac allografts., Transpl. Immunol.
    Mampaso et al., 1993, Expression of adhesion molecules in allograft renal dysfunction. A distinct diagnostic pattern in rejection and cyclosporine nephrotoxicity., Transplantation
    Cronstein et al., 1995, Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils., J. Clin. Invest.
    Torre et al., Effects of interleukin-8 on suppression of human lymphocyte polarization and migration by anti-LFA-1 antibody., Eur. Cytokine Netw.
    Sakamaki et al., 1999, Effects of lung preservation solutions on PMN activation in vitro., Transpl. Int.
    Hayashi et al., 1996, Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimental anti-glomerular basement membrane antibody-associated glomerulonephritis (3)., Eur. J. Pharmacol.
    Settles et al., 2001, Down-regulation of cell adhesion molecules LFA-1 and ICAM-1 after in vitro treatment with the anti-TNF-alpha agent thalidomide., Cell. Mol. Biol. (Noisy-le-grand)
  • BUTEIN   ITGB2

    Interaction Score: 2.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8982701


    Sources:
    NCI

  • ERLIZUMAB   ITGB2

    Interaction Score: 2.99

    Interaction Types & Directionality:
    negative modulator (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin beta-2 negative modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MLNM-2201   ITGB2

    Interaction Score: 2.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin beta-2 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROVELIZUMAB   ITGB2

    Interaction Score: 1.99

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Binding
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • AME-133V   ITGB2

    Interaction Score: 1.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin beta-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIFITEGRAST   ITGB2

    Interaction Score: 1.0

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EFALIZUMAB   ITGB2

    Interaction Score: 1.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-L/beta-2 (LFA-1) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MYCOPHENOLATE MOFETIL   ITGB2

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14550820


    Sources:
    NCI

  • ANTIBIOTIC   ITGB2

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8096833


    Sources:
    NCI

  • SODIUM CHLORIDE   ITGB2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12688543


    Sources:
    NCI

  • METHYLPREDNISOLONE   ITGB2

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8976974


    Sources:
    NCI

  • PREDNISONE   ITGB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8976974


    Sources:
    NCI

  • COLCHICINE   ITGB2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7543498 1363595


    Sources:
    NCI

  • PENTOXIFYLLINE   ITGB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10363593


    Sources:
    NCI

  • THALIDOMIDE   ITGB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11838958


    Sources:
    NCI

  • CYCLOSPORINE   ITGB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9777701 8212167


    Sources:
    NCI

  • INDOMETHACIN   ITGB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11950807


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   ITGB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9523002


    Sources:
    NCI

  • ALCOHOL   ITGB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8803617


    Sources:
    NCI

  • Ensembl: ENSG00000160255

    • Version: 101_38

    Alternate Names:
    ITGB2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P05107

    • Version: 11-September-2012

    Alternate Names:
    P05107 Uniprot Accession
    ENSG00000160255 Ensembl Gene Id
    3689 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR002369
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P05107

    • Version: January-2014

    Alternate Names:
    ITGB2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin

    Publications:

  • RussLampel: ENSG00000160255

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000160255 Ensembl Gene Id
    INTEGRIN BETA-2 PRECURSOR (CELL SURFACE ADHESION GLYCOPROTEINS LFA- 1/CR3/P150,95 BETA-SUBUNIT) (CD18) (COMPLEMENT RECEPTOR C3 BETA- SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05107] Description
    ITGB2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 3689

    • Version: 29-September-2020

    Alternate Names:
    6155 HUGO Gene ID
    6155 HUGO Gene Symbol
    integrin subunit beta 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Integrins
    GuideToPharmacology Gene Category ID 760

    Publications:

  • NCI: ITGB2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Santos-Perez et al., 1996, T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis., Immunol. Lett.
    Lavignac et al., 1996, [Immunohistochemical study of lesions in Horton's temporal arteritis before and during corticotherapy]., Rev Med Interne
    Green et al., 1994, T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA-1-mediated events., Eur. J. Immunol.

  • HingoraniCasas: ENSG00000160255

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000160255 Gene Symbol
    ITGB2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CD18

    • Version: chembl_23

    Alternate Names:
    MFI7 GENE_SYMBOL
    ITGB2 GENE_SYMBOL
    Integrin beta-2 UNIPROT

    Gene Info:

    Publications:

  • GO: ITGB2

    • Version: 05-September-2020

    Alternate Names:
    CD18 GO Gene Synonym
    MFI7 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21