DGIdb - KAT2B Gene Record

KAT2B 8850 Druggable Genome

Alternate Names:

8850
LYSINE ACETYLTRANSFERASE 2B
KAT2B
CAF
P/CAF
PCAF
602303
8638
ENSG00000114166
OTTHUMG00000130481
Q92831
2737
PA162392705
GCN5
GCN5L
NM_003884
NP_003875

Gene Info:

Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	2.3.1.48 Histone acetyltransferases (HATs)
GuideToPharmacology Gene Category ID	872

(3 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
ENZYME

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Milite C et al., 2011, Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)., Bioorg Med Chem
Ghizzoni M et al., 2010, Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative., Bioorg Med Chem
Sbardella G et al., 2008, Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases., Bioorg Med Chem Lett

CHEMBL1797709 KAT2B

Interaction Score: 9.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL404916 KAT2B

Interaction Score: 7.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18434144 21292492

Sources:
DTC
CHEMBL1797711 KAT2B

Interaction Score: 4.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL1797707 KAT2B

Interaction Score: 3.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL416038 KAT2B

Interaction Score: 3.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20655754

Sources:
DTC
CHEMBL257748 KAT2B

Interaction Score: 3.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
CHEMBL1797708 KAT2B

Interaction Score: 3.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21292492

Sources:
DTC
GARCINOL KAT2B

Interaction Score: 1.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
NABIXIMOLS KAT2B

Interaction Score: 1.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PLUMBAGIN KAT2B

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
TRIAZOLAM KAT2B

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
AMPHETAMINE KAT2B

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
COCAINE KAT2B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000114166
- Version: 101_38
Alternate Names:

KAT2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 8850
- Version: 29-September-2020
Alternate Names:

8638 HUGO Gene ID

8638 HUGO Gene Symbol

lysine acetyltransferase 2B HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 2.3.1.48 Histone acetyltransferases (HATs)

GuideToPharmacology Gene Category ID 872

Gene Categories:

ENZYME

Publications:

DTC: KAT2B

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

Milite C et al., 2011, Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)., Bioorg Med Chem

Ghizzoni M et al., 2010, Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative., Bioorg Med Chem

HingoraniCasas: ENSG00000114166
- Version: 31-May-2017
Alternate Names:

ENSG00000114166 Gene Symbol

KAT2B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: KAT2B
- Version: 18-August-2020
Alternate Names:

PA162392705 PharmGKB ID

Gene Info:

Publications:
HumanProteinAtlas: KAT2B
- Version: 19.3
Alternate Names:

ENSG00000114166 Ensembl Gene ID

GCN5 Human Protein Atlas Gene Synonym

GCN5L Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: KAT2B
- Version: 01-May-2021
Alternate Names:

PCAF GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

8638	HUGO Gene ID
8638	HUGO Gene Symbol
lysine acetyltransferase 2B	HUGO Gene Name

ENSG00000114166	Ensembl Gene ID
GCN5	Human Protein Atlas Gene Synonym
GCN5L	Human Protein Atlas Gene Synonym

KAT2B Gene Record

KAT2B 8850 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18434144 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20655754

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21292492

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000114166

Alternate Names: KAT2B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 8850

Alternate Names: 8638 HUGO Gene ID 8638 HUGO Gene Symbol lysine acetyltransferase 2B HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name 2.3.1.48 Histone acetyltransferases (HATs) GuideToPharmacology Gene Category ID 872

Gene Categories: ENZYME

Publications:

DTC: KAT2B

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000114166

Alternate Names: ENSG00000114166 Gene Symbol KAT2B Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: KAT2B

Alternate Names: PA162392705 PharmGKB ID

Gene Info:

Publications:

HumanProteinAtlas: KAT2B

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18434144 21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20655754

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21292492

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

KAT2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

8638 HUGO Gene ID

8638 HUGO Gene Symbol

lysine acetyltransferase 2B HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 2.3.1.48 Histone acetyltransferases (HATs)

GuideToPharmacology Gene Category ID 872

Gene Categories:

ENZYME

Alternate Names:

ENSG00000114166 Gene Symbol

KAT2B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA162392705 PharmGKB ID

Alternate Names:

ENSG00000114166 Ensembl Gene ID

GCN5 Human Protein Atlas Gene Synonym

GCN5L Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

PCAF GO Gene Synonym

Gene Categories:

TRANSCRIPTION FACTOR BINDING