DGIdb - KCNJ3 Gene Record

KCNJ3 3760 Druggable Genome

Alternate Names:

3760
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 3
KCNJ3
GIRK1
KGA
KIR3.1
601534
6264
ENSG00000162989
OTTHUMG00000131937
G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (GIRK1) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3) (INWARD RECTIFIER K(+) CHANNEL KIR3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48549]
P48549
potassium inwardly rectifying channel subfamily J member 3
G protein-activated inward rectifier potassium channel 1

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Transporters
Target Subclass	TC:1.A.2.1
Initial Gene Query	Kir3.1
Counted Citations from 1950-2000	387
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

ION CHANNEL
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Kobayashi et al., 2000, Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes., Br. J. Pharmacol.
Morishige et al., 1999, Secretagogue-induced exocytosis recruits G protein-gated K+ channels to plasma membrane in endocrine cells., J. Biol. Chem.

THYROTROPIN KCNJ3

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10075694

Sources:
NCI
FLUPIRTINE KCNJ3

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name flupirtine,Effirma

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
CLOZAPINE KCNJ3

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10780978

Sources:
NCI

Ensembl: ENSG00000162989
- Version: 101_38
Alternate Names:

KCNJ3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000162989

Version: 26-July-2011

Alternate Names:

G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (GIRK1) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3) (INWARD RECTIFIER K(+) CHANNEL KIR3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48549] Description

ENSG00000162989 Ensembl Gene Id

KCNJ3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: KCNJ3
- Version: February-2014
Alternate Names:

3760 Entrez Gene ID

Gene Info:

Initial Gene Query Kir3.1

Counted Citations from 1950-2000 387

Gene Categories:

ION CHANNEL

Publications:
TdgClinicalTrial: P48549
- Version: January-2014
Alternate Names:

KCNJ3 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.2.1

Publications:

NCI: KCNJ3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Morishige et al., 1999, Secretagogue-induced exocytosis recruits G protein-gated K+ channels to plasma membrane in endocrine cells., J. Biol. Chem.

Kobayashi et al., 2000, Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes., Br. J. Pharmacol.

HingoraniCasas: ENSG00000162989
- Version: 31-May-2017
Alternate Names:

ENSG00000162989 Gene Symbol

KCNJ3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: KCNJ3
- Version: 01-February-2022
Alternate Names:

GIRK1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Pharos: KCNJ3
- Version: 01-February-2022
Alternate Names:

G protein-activated inward rectifier potassium channel 1 Gene Name

P48549 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (GIRK1) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3) (INWARD RECTIFIER K(+) CHANNEL KIR3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48549]	Description
ENSG00000162989	Ensembl Gene Id
KCNJ3	Display Id

G protein-activated inward rectifier potassium channel 1	Gene Name
P48549	UniProt ID

Trial Name	flupirtine,Effirma
Novel drug target	Novel Target

KCNJ3 Gene Record

KCNJ3 3760 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

THYROTROPIN KCNJ3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10075694

Sources: NCI

FLUPIRTINE KCNJ3

Interaction Types & Directionality: n/a

Interaction Info: Trial Name flupirtine,Effirma Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

CLOZAPINE KCNJ3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10780978

Sources: NCI

Ensembl: ENSG00000162989

Alternate Names: KCNJ3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000162989

Alternate Names: G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (GIRK1) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3) (INWARD RECTIFIER K(+) CHANNEL KIR3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48549] Description ENSG00000162989 Ensembl Gene Id KCNJ3 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

BaderLabGenes: KCNJ3

Alternate Names: 3760 Entrez Gene ID

Gene Info: Initial Gene Query Kir3.1 Counted Citations from 1950-2000 387

Gene Categories: ION CHANNEL

Publications:

TdgClinicalTrial: P48549

Alternate Names: KCNJ3 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.2.1

Publications:

NCI: KCNJ3

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000162989

Alternate Names: ENSG00000162989 Gene Symbol KCNJ3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: KCNJ3

Alternate Names: GIRK1 GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Pharos: KCNJ3

Alternate Names: G protein-activated inward rectifier potassium channel 1 Gene Name P48549 UniProt ID

Gene Info:

Gene Categories: ION CHANNEL

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10075694

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name flupirtine,Effirma

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
10780978

Sources:
NCI

Alternate Names:

KCNJ3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (GIRK1) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3) (INWARD RECTIFIER K(+) CHANNEL KIR3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48549] Description

ENSG00000162989 Ensembl Gene Id

KCNJ3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3760 Entrez Gene ID

Gene Info:

Initial Gene Query Kir3.1

Counted Citations from 1950-2000 387

Gene Categories:

ION CHANNEL

Alternate Names:

KCNJ3 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.2.1

Alternate Names:

ENSG00000162989 Gene Symbol

KCNJ3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GIRK1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

G protein-activated inward rectifier potassium channel 1 Gene Name

P48549 UniProt ID

Gene Categories:

ION CHANNEL