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KCNJ6 Gene Record

  • Summary
  • Interactions
  • Claims
  • KCNJ6 3763 Druggable Genome

    Alternate Names:

    3763
    POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 6
    KCNJ6
    BIR1
    GIRK-2
    GIRK2
    KATP-2
    KATP2
    KCNJ7
    KIR3.2
    KPLBS
    hiGIRK2
    600877
    6267
    ENSG00000157542
    OTTHUMG00000086667
    G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2 (GIRK2) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 6) (INWARD RECTIFIER K(+) CHANNEL KIR3.2) (KATP-2) (BIR1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48051]
    P48051
    PA30049
    potassium inwardly rectifying channel subfamily J member 6
    G protein-activated inward rectifier potassium channel 2

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query Kir3.2
    Counted Citations from 1950-2000 261
    Target Class Transporters
    Target Subclass TC:1.A.2.1.10
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Lötsch J et al., 2010, A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size., Pharmacogenet Genomics
    Elens L et al., 2016, Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation., Ther Drug Monit
  • METHADONE   KCNJ6

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20220551


    Sources:
    PharmGKB

  • FLUPIRTINE   KCNJ6

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name flupirtine,Effirma
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MORPHINE   KCNJ6

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27027462


    Sources:
    PharmGKB

  • FENTANYL   KCNJ6

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000157542

    • Version: 101_38

    Alternate Names:
    KCNJ6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000157542

    • Version: 26-July-2011

    Alternate Names:
    KCNJ6 Display Id
    G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2 (GIRK2) (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 6) (INWARD RECTIFIER K(+) CHANNEL KIR3.2) (KATP-2) (BIR1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48051] Description
    ENSG00000157542 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: KCNJ6

    • Version: February-2014

    Alternate Names:
    3763 Entrez Gene ID

    Gene Info:
    Initial Gene Query Kir3.2
    Counted Citations from 1950-2000 261

    Gene Categories:
    ION CHANNEL

    Publications:

  • TdgClinicalTrial: P48051

    • Version: January-2014

    Alternate Names:
    KCNJ6 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.2.1.10

    Publications:

  • PharmGKB: KCNJ6

    • Version: 18-August-2020

    Alternate Names:
    PA30049 PharmGKB ID

    Gene Info:

    Publications:
    Nishizawa D et al., 2009, Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery., PLoS One
    Lötsch J et al., 2010, A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size., Pharmacogenet Genomics
    Elens L et al., 2016, Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation., Ther Drug Monit

  • HingoraniCasas: ENSG00000157542

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000157542 Gene Symbol
    KCNJ6 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: KCNJ6

    • Version: 19.3

    Alternate Names:
    ENSG00000157542 Ensembl Gene ID
    BIR1 Human Protein Atlas Gene Synonym
    GIRK2 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER, ION CHANNEL

    Publications:

  • Pharos: KCNJ6

    • Version: 01-February-2022

    Alternate Names:
    G protein-activated inward rectifier potassium channel 2 Gene Name
    P48051 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21