• KCNMA1 3778 Druggable Genome

    Alternate Names:

    3778
    POTASSIUM CALCIUM-ACTIVATED CHANNEL SUBFAMILY M ALPHA 1
    KCNMA1
    BKTM
    CADEDS
    KCa1.1
    MaxiK
    PNKD3
    SAKCA
    SLO
    SLO-ALPHA
    SLO1
    bA205K10.1
    hSlo
    mSLO1
    600150
    6284
    ENSG00000156113
    OTTHUMG00000018543
    KCNMA
    Maxi K channel
    Calcium-activated potassium channel subunit alpha-1
    BK channel
    BKCA alpha
    Calcium-activated potassium channel, subfamily M subunit alpha-1
    K(VCA)alpha
    Slowpoke homolog
    Slo homolog
    Q12791
    CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT 1 (CALCIUM-ACTIVATED POTASSIUM CHANNEL, SUBFAMILY M, ALPHA SUBUNIT 1) (MAXI K CHANNEL) (MAXIK) (BK CHANNEL) (K(VCA)ALPHA) (BKCA ALPHA) (KCA1.1) (SLOWPOKE HOMOLOG) (SLO HOMOLOG) (SLO-ALPHA) (SLO1) (HSLO). [
    KCMA1_HUMAN
    380
    K<sub>Ca</sub>1.1
    NP_001014797
    NM_001014797
    Calcium-activated potassium channel KCa1.1
    T66538
    IEG16
    LIWAS

    Gene Info:

    Target Class Transporters
    Target Subclass TC:1.A.1.3
    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query Kca1.1
    Counted Citations from 1950-2000 1035
    Uniprot Status Swiss-Prot
    Interpro Short Name Ion_trans_dom
    Interpro Name Ion transport domain
    Interpro Acc IPR005821
    Interpro Type Domain
    Human Readable Name ION CHANNEL
    Uniprot Evidence 1: Evidence at protein level
    GuideToPharmacology Gene Category ID 69
    Target Subclass Ca_Activated_Potassium_Channels
    Target Subclass Voltage_gated_ion_channels
    Transmembrane Helix Count 8
    Target Main Class Transporters
    Target Subclass Channels
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Calcium- and sodium-activated potassium channels
    (7 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME
  • Interaction Score: 7.09

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 3.54

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 3.54

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 activator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.84

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Mechanism of Interaction Calcium-activated potassium channel subunit alpha-1 opener

    PMIDs:
    None found


  • Interaction Score: 2.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 2.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    KCNMA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    KCMA1_HUMAN Uniprot Id
    KCNMA1 Uniprot Gene Name
    ENSG00000156113 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ion_trans_dom

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000156113 Ensembl Gene Id
    KCNMA1 Display Id
    CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT 1 (CALCIUM-ACTIVATED POTASSIUM CHANNEL, SUBFAMILY M, ALPHA SUBUNIT 1) (MAXI K CHANNEL) (MAXIK) (BK CHANNEL) (K(VCA)ALPHA) (BKCA ALPHA) (KCA1.1) (SLOWPOKE HOMOLOG) (SLO HOMOLOG) (SLO-ALPHA) (SLO1) (HSLO). [ Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    3778 Entrez Gene ID

    Gene Info:
    Initial Gene Query Kca1.1
    Counted Citations from 1950-2000 1035

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: January-2014

    Alternate Names:
    KCNMA1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.3

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000156113 Ensembl Gene Id
    3778 Entrez Gene Id
    KCMA1_HUMAN Uniprot Id

    Gene Info:
    Target Subclass Ca_Activated_Potassium_Channels
    Target Subclass Voltage_gated_ion_channels
    Transmembrane Helix Count 8

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    6284 HUGO Gene ID
    6284 HUGO Gene Symbol
    potassium calcium-activated channel subfamily M alpha 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Calcium- and sodium-activated potassium channels
    GuideToPharmacology Gene Category ID 69

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000156113 Gene Symbol
    KCNMA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    SLO GENE_SYMBOL
    KCNMA1 GENE_SYMBOL
    Calcium-activated potassium channel subunit alpha-1 UNIPROT

    Gene Info:

    Publications:

  • Alternate Names:
    KCNMA1 TTD Gene Abbreviation
    T66538 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Calcium-activated potassium channel subunit alpha-1 Gene Name
    Q12791 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: