• Interaction Score: 14.18

    Interaction Types & Directionality:
    activator (activating)
    blocker (inhibitory)

    Interaction Info:
    Trial Name retigabine, ezogabine,Potiga
    Novel drug target Established target
    Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

  • Interaction Score: 2.84

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel subunit Kv7.2 activator
    Direct Interaction yes
    Specific Action of the Ligand None

    PMIDs:
    None found


  • Interaction Score: 1.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.44

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated potassium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.14

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated potassium channel blocker

    PMIDs:
    None found