• KEAP1 9817 Druggable GenomeClinically Actionable

    Alternate Names:

    9817
    KELCH LIKE ECH ASSOCIATED PROTEIN 1
    KEAP1
    INrf2
    KLHL19
    606016
    23177
    ENSG00000079999
    OTTHUMG00000180579
    Q14145
    KIAA0132
    Kelch-like ECH-associated protein 1
    Cytosolic inhibitor of Nrf2
    Kelch-like protein 19
    kelch like ECH-associated protein 1
    NP_036421
    2757
    NM_012289

    Gene Info:

    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Kelch-like proteins
    GuideToPharmacology Gene Category ID 876
    (7 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 31.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Kelch-like ECH-associated protein 1 inhibitor

    PMIDs:
    23647822


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of KEAP1 binding to Cul3 using an AlphaScreen bead-based proximity assay.
    Specific Action of the Ligand Binding
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Keap1/Nrf2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    KEAP1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    23177 HUGO Gene ID
    23177 HUGO Gene Symbol
    kelch like ECH associated protein 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Kelch-like proteins
    GuideToPharmacology Gene Category ID 876

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000079999 Gene Symbol
    KEAP1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    KIAA0132 GENE_SYMBOL
    KLHL19 GENE_SYMBOL
    KEAP1 GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 11-November-2018

    Alternate Names:
    KEAP1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    INRF2 GO Gene Synonym
    KIAA0132 GO Gene Synonym
    KLHL19 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Kelch-like ECH-associated protein 1 Gene Name
    Q14145 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: