DGIdb - KLK3 Gene Record

KLK3 354 Druggable Genome

Alternate Names:

354
KALLIKREIN RELATED PEPTIDASE 3
KLK3
APS
KLK2A1
PSA
hK3
176820
6364
ENSG00000142515
OTTHUMG00000182867
P07288
PROSTATE SPECIFIC ANTIGEN PRECURSOR (EC 3.4.21.77) (PSA) (GAMMA- SEMINOPROTEIN) (KALLIKREIN 3) (SEMENOGELASE) (SEMININ) (P-30 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07288]
KLK3_HUMAN
PROSTATE-SPECIFIC ANTIGEN
PKK
Plasma prekallikrein
Kininogenin
Fletcher factor
Plasma kallikrein light chain
Plasma kallikrein heavy chain
Plasma kallikrein
KLKB1
Prostate specific antigen
T36935

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.4.21.77
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	PROTEASE
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Short Name	Peptidase_S1_S6
Interpro Type	Domain
Interpro Acc	IPR001254
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME

Publications:

Zarghami et al., 1997, Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer., Br. J. Cancer
Tomera et al., 2001, The gonadotropin-releasing hormone antagonist abarelix depot versus luteinizing hormone releasing hormone agonists leuprolide or goserelin: initial results of endocrinological and biochemical efficacies in patients with prostate cancer., J. Urol.
Kang Z et al., 2004, Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor., Mol Endocrinol
Yu et al., 1994, Induction of prostate specific antigen production by steroids and tamoxifen in breast cancer cell lines., Breast Cancer Res. Treat.
Munshi et al., 2001, Chemotherapy in patients with prostate specific antigen-only disease after primary therapy for prostate carcinoma: a phase II trial of oral estramustine and oral etoposide., Cancer
Vijayakumar et al., 1995, Results of a study to correlate serum prostate specific antigen and reproductive hormone levels in patients with localized prostate cancer., J Natl Med Assoc
Verhelst et al., 1994, Octreotide in advanced prostatic cancer relapsing under hormonal treatment., Acta Urol Belg
Springate et al., 2005, Efficacy of an intratumoral controlled release formulation of clusterin antisense oligonucleotide complexed with chitosan containing paclitaxel or docetaxel in prostate cancer xenograft models., Cancer Chemother. Pharmacol.
Weitzman et al., 2000, Dexamethasone does not significantly contribute to the response rate of docetaxel and estramustine in androgen independent prostate cancer., J. Urol.
Bhamre et al., 2003, Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth., Prostate
Seidman et al., 1992, Estramustine and vinblastine: use of prostate specific antigen as a clinical trial end point for hormone refractory prostatic cancer., J. Urol.
Fowler et al., 1995, Prostate specific antigen after gonadal androgen withdrawal and deferred flutamide treatment., J. Urol.
Davis et al., 2000, Inhibition of prostate specific antigen expression by genistein in prostate cancer cells., Int. J. Oncol.
Sadar, 1999, Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways., J. Biol. Chem.
Dijkman et al., 1997, Long-term efficacy and safety of nilutamide plus castration in advanced prostate cancer, and the significance of early prostate specific antigen normalization. International Anandron Study Group., J. Urol.

TOPSALYSIN KLK3

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PRX302

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
SELENOMETHIONINE KLK3

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12539231

Sources:
NCI
ABARELIX KLK3

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11342922

Sources:
NCI
BICALUTAMIDE KLK3

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10075669

Sources:
NCI
APROTININ KLK3

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Plasma kallikrein inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
NILUTAMIDE KLK3

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9186345

Sources:
NCI
ECALLANTIDE KLK3

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Plasma kallikrein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANDROSTENEDIONE KLK3

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8907816

Sources:
NCI
OCTREOTIDE KLK3

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7515212

Sources:
NCI
ESTRAMUSTINE KLK3

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11391599

Sources:
NCI
MIFEPRISTONE KLK3

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9052414 15308689

Sources:
NCI
FLUTAMIDE KLK3

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7541862

Sources:
NCI
VINBLASTINE KLK3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1371564

Sources:
NCI
GENISTEIN KLK3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10811979

Sources:
NCI
DOCETAXEL KLK3

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15864591 10687988

Sources:
NCI
ETOPOSIDE KLK3

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11391599

Sources:
NCI
TAMOXIFEN KLK3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7532467

Sources:
NCI
PROGESTERONE KLK3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9052414

Sources:
NCI

Ensembl: ENSG00000142515
- Version: 101_38
Alternate Names:

KLK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000142515

Version: 26-July-2011

Alternate Names:

ENSG00000142515 Ensembl Gene Id

KLK3 Display Id

PROSTATE SPECIFIC ANTIGEN PRECURSOR (EC 3.4.21.77) (PSA) (GAMMA- SEMINOPROTEIN) (KALLIKREIN 3) (SEMENOGELASE) (SEMININ) (P-30 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07288] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P07288
- Version: January-2014
Alternate Names:

KLK3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.77

Publications:
HopkinsGroom: P07288
- Version: 11-September-2012
Alternate Names:

KLK3 Uniprot Gene Name

KLK3_HUMAN Uniprot Id

354 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:

NCI: KLK3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Zarghami et al., 1997, Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer., Br. J. Cancer

Verhelst et al., 1994, Octreotide in advanced prostatic cancer relapsing under hormonal treatment., Acta Urol Belg

Davis et al., 2000, Inhibition of prostate specific antigen expression by genistein in prostate cancer cells., Int. J. Oncol.

ChemblInteractions: KLK3
- Version: chembl_23
Alternate Names:

KLK3 GENE_SYMBOL

KLKB1 GENE_SYMBOL

Plasma kallikrein UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000142515
- Version: 31-May-2017
Alternate Names:

ENSG00000142515 Gene Symbol

KLK3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: KLK3
- Version: 27-Jun-2013
Alternate Names:

354 Gene ID

APS dGene Synonym

KLK2A1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Prostate specific antigen
- Version: 2020.06.01
Alternate Names:

KLK3 TTD Gene Abbreviation

T36935 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Plasma kallikrein inhibitor

ENSG00000142515	Ensembl Gene Id
KLK3	Display Id
PROSTATE SPECIFIC ANTIGEN PRECURSOR (EC 3.4.21.77) (PSA) (GAMMA- SEMINOPROTEIN) (KALLIKREIN 3) (SEMENOGELASE) (SEMININ) (P-30 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07288]	Description

Trial Name	PRX302
Novel drug target	Novel Target

KLK3 Gene Record

KLK3 354 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name PRX302 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12539231

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11342922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10075669

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Plasma kallikrein inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9186345

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Plasma kallikrein inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8907816

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7515212

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11391599

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9052414 15308689

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7541862

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1371564

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10811979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15864591 10687988

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11391599

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7532467

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9052414

Sources: NCI

Ensembl: ENSG00000142515

Alternate Names: KLK3 Ensembl Gene Name

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PRX302

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
12539231

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11342922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10075669

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Plasma kallikrein inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
9186345

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Plasma kallikrein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
8907816

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7515212

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11391599

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9052414 15308689

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7541862

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1371564

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10811979

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15864591 10687988

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11391599

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7532467

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9052414

Sources:
NCI

Alternate Names:

KLK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000142515 Ensembl Gene Id

KLK3 Display Id

PROSTATE SPECIFIC ANTIGEN PRECURSOR (EC 3.4.21.77) (PSA) (GAMMA- SEMINOPROTEIN) (KALLIKREIN 3) (SEMENOGELASE) (SEMININ) (P-30 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07288] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KLK3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.77

Alternate Names:

KLK3 Uniprot Gene Name

KLK3_HUMAN Uniprot Id

354 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

KLK3 GENE_SYMBOL

KLKB1 GENE_SYMBOL

Plasma kallikrein UNIPROT

Alternate Names:

ENSG00000142515 Gene Symbol

KLK3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

354 Gene ID

APS dGene Synonym

KLK2A1 dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

KLK3 TTD Gene Abbreviation

T36935 TTD Target ID