DGIdb - LDLR Gene Record

LDLR 3949 Druggable Genome

Alternate Names:

3949
LOW DENSITY LIPOPROTEIN RECEPTOR
LDLR
FH
FHC
LDLCQ2
606945
6547
ENSG00000130164
OTTHUMG00000171935
PA227
Low-density lipoprotein receptor
LDL-R
T94692
FHCL1
P01130

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
ENZYME

Publications:

Goto et al., 1997, Upregulation of low density lipoprotein receptor by gemfibrozil, a hypolipidemic agent, in human hepatoma cells through stabilization of mRNA transcripts., Arterioscler. Thromb. Vasc. Biol.
Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
Wathne et al., 1989, Uptake of retinyl ester in HL-60 cells via the low-density-lipoprotein-receptor pathway., Biochem. J.
Hay BA et al., 2007, Aminopyrrolidineamide inhibitors of site-1 protease., Bioorg Med Chem Lett
Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology
Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci
Miura et al., 1998, Enhancement of low density lipoprotein binding to both low density lipoprotein receptor-positive and -negative cells by tetracycline antibiotics., Lipids
Su et al., 2006, Evaluation of tributyrin lipid emulsion with affinity to low-density lipoprotein: pharmacokinetics in adult male Wistar rats and cellular activity on Caco-2 and HepG2 cell lines., J. Pharmacol. Exp. Ther.
Liljedahl et al., 2004, Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment., BMC Cardiovasc Disord
Rudling et al., 1990, Low density lipoprotein receptor-binding activity in human tissues: quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo., Proc. Natl. Acad. Sci. U.S.A.
Pineda JA et al., 2011, Low-density lipoprotein receptor genotyping enhances the predictive value of IL28B genotype in HIV/hepatitis C virus-coinfected patients., AIDS
Liang et al., 1997, Gene expression of LDL receptor, HMG-CoA reductase, and cholesterol-7 alpha-hydroxylase in chronic renal failure., Nephrol. Dial. Transplant.
Zheng et al., 2002, The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state., Free Radic. Biol. Med.
Block et al., 1993, Transcriptional activation of low density lipoprotein receptor gene by angiotensin-converting enzyme inhibitors and Ca(2+)-channel blockers involves protein kinase C isoforms., Proc. Natl. Acad. Sci. U.S.A.
Brown et al., 1989, Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes., Biochem. J.

CHEMBL233611 LDLR

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17583500

Sources:
DTC
CHOLESTYRAMINE LDLR

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2110363

Sources:
NCI
ALIROCUMAB LDLR

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TRIBUTYRIN LDLR

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16188956

Sources:
NCI
MIPOMERSEN LDLR

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
EVOLOCUMAB LDLR

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOMITAPIDE LDLR

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
GLUCAGON LDLR

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2552996

Sources:
NCI
CORTICOTROPIN LDLR

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11956163

Sources:
NCI
GEMFIBROZIL LDLR

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9409246

Sources:
NCI
RETINOL LDLR

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2920014

Sources:
NCI
ACETYLCYSTEINE LDLR

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12031897

Sources:
NCI
TETRACYCLINE LDLR

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9470171

Sources:
NCI
EPOETIN ALFA LDLR

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9249773

Sources:
NCI
ATENOLOL LDLR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15453913

Sources:
NCI PharmGKB
RIBAVIRIN LDLR

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21572301

Sources:
PharmGKB
VERAPAMIL LDLR

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7683421

Sources:
NCI
LOVASTATIN LDLR

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16103896

Sources:
PharmGKB
HALOPERIDOL LDLR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17052361

Sources:
NCI
PRAVASTATIN LDLR

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ATORVASTATIN LDLR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000130164
- Version: 101_38
Alternate Names:

LDLR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: LDLR

Version: 18-August-2020

Alternate Names:

PA227 PharmGKB ID

Gene Info:

Publications:

Pineda JA et al., 2011, Low-density lipoprotein receptor genotyping enhances the predictive value of IL28B genotype in HIV/hepatitis C virus-coinfected patients., AIDS

Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J

NCI: LDLR

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Miura et al., 1998, Enhancement of low density lipoprotein binding to both low density lipoprotein receptor-positive and -negative cells by tetracycline antibiotics., Lipids

Larivière et al., 2003, Effects of atorvastatin on electrophoretic characteristics of LDL particles among subjects with heterozygous familial hypercholesterolemia., Atherosclerosis

Owen et al., 2004, Regulation of low-density lipoprotein receptor activity by estrogens and phytoestrogens in a HepG2 cell model., Ann. Nutr. Metab.

DTC: LDLR
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Hay BA et al., 2007, Aminopyrrolidineamide inhibitors of site-1 protease., Bioorg Med Chem Lett
HingoraniCasas: ENSG00000130164
- Version: 31-May-2017
Alternate Names:

ENSG00000130164 Gene Symbol

LDLR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: LDLR
- Version: 11-November-2018
Alternate Names:

LDLR Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Low-density lipoprotein receptor
- Version: 2020.06.01
Alternate Names:

LDL-R TTD Gene Abbreviation

T94692 TTD Target ID

Gene Info:

Publications:
Pharos: LDLR
- Version: 01-February-2022
Alternate Names:

Low-density lipoprotein receptor Gene Name

P01130 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: LDLR
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

LDLR Gene Record

LDLR 3949 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17583500

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2110363

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16188956

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2552996

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11956163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9409246

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2920014

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12031897

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9470171

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9249773

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15453913

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21572301

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7683421

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16103896

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17583500

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
2110363

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16188956

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2552996

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11956163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9409246

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2920014

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12031897

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9470171

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9249773

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15453913

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21572301

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7683421

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16103896

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17052361

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

LDLR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA227 PharmGKB ID

Publications:

Hay BA et al., 2007, Aminopyrrolidineamide inhibitors of site-1 protease., Bioorg Med Chem Lett

Alternate Names:

ENSG00000130164 Gene Symbol

LDLR Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

LDLR Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

LDL-R TTD Gene Abbreviation

T94692 TTD Target ID

Alternate Names:

Low-density lipoprotein receptor Gene Name

P01130 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE