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LDLR Gene Record

  • Summary
  • Interactions
  • Claims
  • LDLR 3949 Druggable Genome

    Alternate Names:

    3949
    LOW DENSITY LIPOPROTEIN RECEPTOR
    LDLR
    FH
    FHC
    LDLCQ2
    606945
    6547
    ENSG00000130164
    OTTHUMG00000171935
    PA227
    Low-density lipoprotein receptor
    LDL-R
    T94692
    FHCL1
    P01130

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Goto et al., 1997, Upregulation of low density lipoprotein receptor by gemfibrozil, a hypolipidemic agent, in human hepatoma cells through stabilization of mRNA transcripts., Arterioscler. Thromb. Vasc. Biol.
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Wathne et al., 1989, Uptake of retinyl ester in HL-60 cells via the low-density-lipoprotein-receptor pathway., Biochem. J.
    Hay BA et al., 2007, Aminopyrrolidineamide inhibitors of site-1 protease., Bioorg Med Chem Lett
    Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology
    Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci
    Miura et al., 1998, Enhancement of low density lipoprotein binding to both low density lipoprotein receptor-positive and -negative cells by tetracycline antibiotics., Lipids
    Su et al., 2006, Evaluation of tributyrin lipid emulsion with affinity to low-density lipoprotein: pharmacokinetics in adult male Wistar rats and cellular activity on Caco-2 and HepG2 cell lines., J. Pharmacol. Exp. Ther.
    Liljedahl et al., 2004, Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment., BMC Cardiovasc Disord
    Rudling et al., 1990, Low density lipoprotein receptor-binding activity in human tissues: quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo., Proc. Natl. Acad. Sci. U.S.A.
    Pineda JA et al., 2011, Low-density lipoprotein receptor genotyping enhances the predictive value of IL28B genotype in HIV/hepatitis C virus-coinfected patients., AIDS
    Liang et al., 1997, Gene expression of LDL receptor, HMG-CoA reductase, and cholesterol-7 alpha-hydroxylase in chronic renal failure., Nephrol. Dial. Transplant.
    Zheng et al., 2002, The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state., Free Radic. Biol. Med.
    Block et al., 1993, Transcriptional activation of low density lipoprotein receptor gene by angiotensin-converting enzyme inhibitors and Ca(2+)-channel blockers involves protein kinase C isoforms., Proc. Natl. Acad. Sci. U.S.A.
    Brown et al., 1989, Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes., Biochem. J.
  • CHEMBL233611   LDLR

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17583500


    Sources:
    DTC

  • CHOLESTYRAMINE   LDLR

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2110363


    Sources:
    NCI

  • ALIROCUMAB   LDLR

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TRIBUTYRIN   LDLR

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16188956


    Sources:
    NCI

  • MIPOMERSEN   LDLR

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EVOLOCUMAB   LDLR

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOMITAPIDE   LDLR

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GLUCAGON   LDLR

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2552996


    Sources:
    NCI

  • CORTICOTROPIN   LDLR

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11956163


    Sources:
    NCI

  • GEMFIBROZIL   LDLR

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9409246


    Sources:
    NCI

  • RETINOL   LDLR

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2920014


    Sources:
    NCI

  • ACETYLCYSTEINE   LDLR

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12031897


    Sources:
    NCI

  • TETRACYCLINE   LDLR

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9470171


    Sources:
    NCI

  • EPOETIN ALFA   LDLR

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9249773


    Sources:
    NCI

  • ATENOLOL   LDLR

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15453913


    Sources:
    NCI PharmGKB

  • RIBAVIRIN   LDLR

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21572301


    Sources:
    PharmGKB

  • VERAPAMIL   LDLR

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7683421


    Sources:
    NCI

  • LOVASTATIN   LDLR

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896


    Sources:
    PharmGKB

  • HALOPERIDOL   LDLR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17052361


    Sources:
    NCI

  • PRAVASTATIN   LDLR

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ATORVASTATIN   LDLR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000130164

    • Version: 101_38

    Alternate Names:
    LDLR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: LDLR

    • Version: 18-August-2020

    Alternate Names:
    PA227 PharmGKB ID

    Gene Info:

    Publications:
    Pineda JA et al., 2011, Low-density lipoprotein receptor genotyping enhances the predictive value of IL28B genotype in HIV/hepatitis C virus-coinfected patients., AIDS
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J

  • NCI: LDLR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Miura et al., 1998, Enhancement of low density lipoprotein binding to both low density lipoprotein receptor-positive and -negative cells by tetracycline antibiotics., Lipids
    Larivière et al., 2003, Effects of atorvastatin on electrophoretic characteristics of LDL particles among subjects with heterozygous familial hypercholesterolemia., Atherosclerosis
    Owen et al., 2004, Regulation of low-density lipoprotein receptor activity by estrogens and phytoestrogens in a HepG2 cell model., Ann. Nutr. Metab.

  • DTC: LDLR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Hay BA et al., 2007, Aminopyrrolidineamide inhibitors of site-1 protease., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000130164

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000130164 Gene Symbol
    LDLR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: LDLR

    • Version: 11-November-2018

    Alternate Names:
    LDLR Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Low-density lipoprotein receptor

    • Version: 2020.06.01

    Alternate Names:
    LDL-R TTD Gene Abbreviation
    T94692 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: LDLR

    • Version: 01-February-2022

    Alternate Names:
    Low-density lipoprotein receptor Gene Name
    P01130 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: LDLR

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21