• LTA 4049 Druggable GenomeDrug Resistance

    Alternate Names:

    4049
    LYMPHOTOXIN ALPHA
    LTA
    LT
    TNFB
    TNFSF1
    TNLG1E
    153440
    6709
    ENSG00000226979
    OTTHUMG00000031135
    LT-alpha
    Lymphotoxin-alpha
    Tumor necrosis factor ligand superfamily member 1
    TNF-beta
    P01374
    PA30474
    T85158

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    DRUGGABLE GENOME
  • Interaction Score: 15.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction TNF-beta inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.97

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Heterotrimeric lymphotoxin LTa1b2 inhibitor
    Direct Interaction yes
    Trial Name baminercept, BG-9924

    PMIDs:
    None found


  • Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11294926


    Sources:
    PharmGKB