DGIdb - LTA4H Gene Record

LTA4H 4048 Druggable Genome

Alternate Names:

4048
LEUKOTRIENE A4 HYDROLASE
LTA4H
151570
6710
ENSG00000111144
OTTHUMG00000170355
BE0001680
P09960
1395
NM_000895\|NM_001256643\|NM_001256644
Leukotriene A<sub>4</sub> hydrolase
NP_000886\|NP_001243572\|NP_001243573
PA24345
LEUKOTRIENE A-4 HYDROLASE
LTA4
LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P09960]
T03691
-

Gene Info:

GuideToPharmacology Gene Category Name	M1: Aminopeptidase N
GuideToPharmacology Gene Category ID	737
Target Class	Enzymes
Target Subclass	EC:3.3.2.6
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799
GuideToPharmacology Gene Category Name	Leukotriene and lipoxin metabolism
GuideToPharmacology Gene Category ID	272

(9 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Jiang X et al., 2008, Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives., Bioorg Med Chem Lett
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Orning et al., 1992, Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase., Biochemistry
Thunnissen et al., 2002, Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors., FASEB J.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

UBENIMEX LTA4H

Interaction Score: 6.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17016423 17139284

Sources:
DrugBank
CHEMBL549343 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL538940 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
DIHYDRORESVERATROL LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL570775 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL264669 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL478381 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL563196 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL561639 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL483790 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL479960 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL539640 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL478718 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
KELATORPHAN LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL444161 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18952425

Sources:
DTC
CHEMBL455078 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18952425

Sources:
DTC
CHEMBL398021 LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18952425

Sources:
DTC
DIPHENYLETHER LTA4H

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18952425

Sources:
DTC
CHEMBL194009 LTA4H

Interaction Score: 2.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL119054 LTA4H

Interaction Score: 2.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ACEBILUSTAT LTA4H

Interaction Score: 2.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL224318 LTA4H

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18952425

Sources:
DTC
IMIDAZOLE LTA4H

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ALBUMIN HUMAN LTA4H

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1314659

Sources:
NCI
CAPTOPRIL LTA4H

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12207002

Sources:
DrugBank
MONTELUKAST LTA4H

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TOSEDOSTAT LTA4H

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank

Ensembl: ENSG00000111144
- Version: 101_38
Alternate Names:

LTA4H Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000111144

Version: 26-July-2011

Alternate Names:

LTA4H Display Id

ENSG00000111144 Ensembl Gene Id

LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P09960] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P09960
- Version: January-2014
Alternate Names:

LTA4H Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.3.2.6

Publications:
GuideToPharmacology: 4048
- Version: 29-September-2020
Alternate Names:

6710 HUGO Gene ID

6710 HUGO Gene Symbol

leukotriene A4 hydrolase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Hydrolases

GuideToPharmacology Gene Category ID 799

GuideToPharmacology Gene Category Name Leukotriene and lipoxin metabolism

Gene Categories:

ENZYME

Publications:

DrugBank: BE0001680

Version: 5.1.7

Alternate Names:

LTA4H DrugBank Gene Name

P09960 UniProt Accession

4048 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: LTA4H

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Yuan et al., 1993, Development of selective tight-binding inhibitors of leukotriene A4 hydrolase., J. Med. Chem.

Griffin et al., 1992, Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase., Prostaglandins

Orning et al., 1992, Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase., Biochemistry

DTC: LTA4H
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Jiang X et al., 2008, Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives., Bioorg Med Chem Lett
HingoraniCasas: ENSG00000111144
- Version: 31-May-2017
Alternate Names:

ENSG00000111144 Gene Symbol

LTA4H Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: LTA4H
- Version: 18-August-2020
Alternate Names:

PA24345 PharmGKB ID

Gene Info:

Publications:
Pharos: LTA4H
- Version: 03-September-2020
Alternate Names:

Leukotriene A-4 hydrolase Gene Name

P09960 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: LTA4H
- Version: 05-September-2020
Alternate Names:

LTA4 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
dGene: LTA4H
- Version: 27-Jun-2013
Alternate Names:

4048 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Leukotriene A-4 hydrolase
- Version: 2020.06.01
Alternate Names:

LTA4H TTD Gene Abbreviation

T03691 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

LTA4H	Display Id
ENSG00000111144	Ensembl Gene Id
LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P09960]	Description

6710	HUGO Gene ID
6710	HUGO Gene Symbol
leukotriene A4 hydrolase	HUGO Gene Name

LTA4H	DrugBank Gene Name
P09960	UniProt Accession
4048	Entrez Gene Id

LTA4H Gene Record

LTA4H 4048 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17016423 17139284

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18952425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18952425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18952425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18952425

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
18952425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18952425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18952425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18952425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
18952425

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1314659

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
12207002

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a