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LTA4H Gene Record

  • Summary
  • Interactions
  • Claims
  • LTA4H 4048 Druggable Genome

    Alternate Names:

    4048
    LEUKOTRIENE A4 HYDROLASE
    LTA4H
    151570
    6710
    ENSG00000111144
    OTTHUMG00000170355
    P09960
    PA24345
    LEUKOTRIENE A-4 HYDROLASE
    LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P09960]
    T03691
    -
    LTA4

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.3.2.6
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Jiang X et al., 2008, Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives., Bioorg Med Chem Lett
    Orning et al., 1992, Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase., Biochemistry
  • CHEMBL444161   LTA4H

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18952425


    Sources:
    DTC

  • CHEMBL455078   LTA4H

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18952425


    Sources:
    DTC

  • CHEMBL398021   LTA4H

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18952425


    Sources:
    DTC

  • DIPHENYLETHER   LTA4H

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18952425


    Sources:
    DTC

  • ACEBILUSTAT   LTA4H

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL224318   LTA4H

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18952425


    Sources:
    DTC

  • ALBUMIN HUMAN   LTA4H

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1314659


    Sources:
    NCI

  • MONTELUKAST   LTA4H

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000111144

    • Version: 101_38

    Alternate Names:
    LTA4H Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000111144

    • Version: 26-July-2011

    Alternate Names:
    LTA4H Display Id
    ENSG00000111144 Ensembl Gene Id
    LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P09960] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P09960

    • Version: January-2014

    Alternate Names:
    LTA4H Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.3.2.6

    Publications:

  • NCI: LTA4H

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Yuan et al., 1993, Development of selective tight-binding inhibitors of leukotriene A4 hydrolase., J. Med. Chem.
    Griffin et al., 1992, Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase., Prostaglandins
    Orning et al., 1992, Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase., Biochemistry

  • DTC: LTA4H

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Jiang X et al., 2008, Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000111144

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111144 Gene Symbol
    LTA4H Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: LTA4H

    • Version: 18-August-2020

    Alternate Names:
    PA24345 PharmGKB ID

    Gene Info:

    Publications:

  • GO: LTA4H

    • Version: 01-February-2022

    Alternate Names:
    LTA4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • dGene: LTA4H

    • Version: 27-Jun-2013

    Alternate Names:
    4048 Gene ID
    - dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Leukotriene A-4 hydrolase

    • Version: 2020.06.01

    Alternate Names:
    LTA4H TTD Gene Abbreviation
    T03691 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: LTA4H

    • Version: 01-February-2022

    Alternate Names:
    Leukotriene A-4 hydrolase Gene Name
    P09960 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21