• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

LTC4S Gene Record

  • Summary
  • Interactions
  • Claims
  • LTC4S 4056 Druggable Genome

    Alternate Names:

    4056
    LEUKOTRIENE C4 SYNTHASE
    LTC4S
    246530
    6719
    ENSG00000213316
    OTTHUMG00000150314
    Q16873
    LTC4S_HUMAN
    PA235
    ENSG00000161018
    LEUKOTRIENE C4 SYNTHASE (EC 4.4.1.20) (LEUKOTRIENE-C(4) SYNTHASE) (LTC4 SYNTHASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16873]
    T72881
    MGC33147

    Gene Info:

    Interpro Name Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Membr-assoc_MAPEG
    Interpro Type Family
    Interpro Acc IPR001129
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Sánchez-Borges M et al., 2009, The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria., J Investig Allergol Clin Immunol
    Mastalerz L et al., 2006, Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant., Br J Dermatol
    Mastalerz L et al., 2004, Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma., J Allergy Clin Immunol
  • ASPIRIN   LTC4S

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19862937 16433794 15100686


    Sources:
    PharmGKB

  • MONTELUKAST   LTC4S

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000213316

    • Version: 101_38

    Alternate Names:
    LTC4S Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000161018

    • Version: 26-July-2011

    Alternate Names:
    LTC4S Display Id
    LEUKOTRIENE C4 SYNTHASE (EC 4.4.1.20) (LEUKOTRIENE-C(4) SYNTHASE) (LTC4 SYNTHASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16873] Description
    ENSG00000161018 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q16873

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000213316 Ensembl Gene Id
    LTC4S Uniprot Gene Name
    Q16873 Uniprot Accession

    Gene Info:
    Interpro Name Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Membr-assoc_MAPEG

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: LTC4S

    • Version: 18-August-2020

    Alternate Names:
    PA235 PharmGKB ID

    Gene Info:

    Publications:
    Sánchez-Borges M et al., 2009, The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria., J Investig Allergol Clin Immunol
    Mastalerz L et al., 2004, Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma., J Allergy Clin Immunol
    Mastalerz L et al., 2006, Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant., Br J Dermatol

  • HumanProteinAtlas: LTC4S

    • Version: 19.3

    Alternate Names:
    ENSG00000213316 Ensembl Gene ID
    MGC33147 Human Protein Atlas Gene Synonym
    Leukotriene C4 synthase Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Leukotriene C4 synthase

    • Version: 2020.06.01

    Alternate Names:
    LTC4S TTD Gene Abbreviation
    T72881 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: LTC4S

    • Version: 01-February-2022

    Alternate Names:
    Leukotriene C4 synthase Gene Name
    Q16873 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21