DGIdb - MAPK1 Gene Record

MAPK1 5594 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

5594
MITOGEN-ACTIVATED PROTEIN KINASE 1
MAPK1
ERK
ERK-2
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
p42-MAPK
176948
6871
ENSG00000100030
OTTHUMG00000030508
1495
P28482
NP_002736
NM_002745
Extracellular signal-regulated kinase 2
MAP kinase isoform p42
Mitogen-activated protein kinase 2
MAP kinase 1
MAPK 1
MAP kinase 2
MAPK 2
MK01_HUMAN
MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482]
4532
PA30616
T58970
NS13

Gene Info:

GuideToPharmacology Gene Category Name	ERK subfamily
GuideToPharmacology Gene Category ID	514
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Human Readable Name	KINASE
Interpro Type	Domain
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUG RESISTANCE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME
TRANSCRIPTION FACTOR

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod
Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
Milosevic et al., 2006, Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling., J. Neurochem.
Pavón et al., 2006, ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice., Biol. Psychiatry
Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol
Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.
Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res
Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther
Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem
Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod
Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Tanigawa et al., 2007, Rebamipide inhibits gastric cancer cell growth., Dig. Dis. Sci.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.
Yang CL et al., 2009, Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages., J Med Chem

RAVOXERTINIB MAPK1

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
25320010

Sources:
ChemblInteractions GuideToPharmacology TTD
CIMIRACEMATE A MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19835377

Sources:
DTC
CHEMBL2088730 MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
CHEMBL2063681 MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22283430

Sources:
DTC
CHEMBL2063687 MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22283430

Sources:
DTC
ULIXERTINIB MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Biochemical assay determination

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
28939558

Sources:
ChemblInteractions GuideToPharmacology TTD
PESUDOGINSENOSIDE RP1 METHYL ESTER MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20951582

Sources:
DTC
CHEMBL1485809 MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2088731 MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
CHEMBL329785 MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
SPINASAPONIN A METHYL ESTER MAPK1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20951582

Sources:
DTC
REBAMIPIDE MAPK1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17171453

Sources:
NCI
MK-8353 MAPK1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
IROFULVEN MAPK1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12014623

Sources:
NCI
BENZALKONIUM CHLORIDE MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL261237 MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ARISTOYUNNOLIN A MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VOLVALERENAL D MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MADOLIN T MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MADOLIN A MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2333543 MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2333548 MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
URACIL MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17076658

Sources:
NCI
ARISTOLACTONE MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MADOLIN U MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CANTHARIDIN MAPK1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEMETHYLWEDELOLACTONE MAPK1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926226

Sources:
DTC
YUANHUADINE MAPK1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21916433

Sources:
DTC
ETHER MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16081674

Sources:
NCI
XANTHOHUMOL MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22111577

Sources:
DTC
MUNDULONE ACETATE MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OPHIOBOLIN O MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22130129

Sources:
DTC
CHEMBL484662 MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GAMBOGIC AMIDE MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17911251

Sources:
DTC
CHEMBL76589 MAPK1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPHENHYDRAMINE HYDROCHLORIDE MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL532849 MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZALCITABINE MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHELERYTHRINE CHLORIDE MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENMEDIPHAM MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MUNDULONE MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1939691 MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL184074 MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL29197 MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17681471

Sources:
DTC
SAPPANONE A TRIMETHYL ETHER MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENETHYLISOTHIOCYANATE MAPK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22607231

Sources:
DTC
GAMBOGIC ACID MAPK1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17911251

Sources:
DTC
NAFTOPIDIL MAPK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL580183 MAPK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581194 MAPK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TREQUINSIN HYDROCHLORIDE MAPK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WEDELOLACTONE MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926226

Sources:
DTC
CHIR-99021 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD
CHEMBL597035 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL210618 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL580340 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL531322 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL126804 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TYRPHOSTIN AG-1478 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WITHAFERIN A MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20726569

Sources:
DTC
CHLORHEXIDINE HYDROCHLORIDE MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
O-DEMETHYLATED ADAPALENE MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL530280 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DERRUBONE MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL585628 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1270169 MAPK1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RELCOVAPTAN MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALPHA-NAPHTHOFLAVONE MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GF-109203 MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581872 MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581574 MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1814509 MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUMETANIDE MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11807827

Sources:
NCI
CHEMBL547833 MAPK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BISINDOLYLMALEIMIDE IX MAPK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW282974X MAPK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NECA MAPK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SANGUINARIUM CHLORIDE MAPK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL88272 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COMBRETASTATIN A4 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
CHEMBL421215 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-1487 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIOCHANIN MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1493528 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PATULIN MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAPH MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
U-0126 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LITHOCHOLIC ACID MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL609606 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL285819 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578944 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1224755 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL261557 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL222556 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ECONAZOLE NITRATE MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL154580 MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIHYDROGAMBOGIC ACID MAPK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLOROTHALONIL MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GUTHION MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-169316 MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IPRIFLAVONE MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CAPTAN MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SANGUINARINE SULFATE MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FISETIN MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL586031 MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZIRAM MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PLUMBAGIN MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-220025 MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DTC
QUINALIZARIN MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL428789 MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL84010 MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORANIL MAPK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TYRPHOSTIN 47 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORATADINE MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOVELLERAL MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1519374 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INDIRUBIN-3-MONOXIME MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIBEFRADIL MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZAFIRLUKAST MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENTIAN VIOLET MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2095095 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLIOQUINOL MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVODOPA MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16139809

Sources:
NCI
ACID BLUE 129 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CALCIMYCIN MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GR-127935 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENYLMERCURIC ACETATE MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MERCURIC CHLORIDE MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PURPURIN MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578741 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIMEROSAL MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CI-1040 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SANGUINARIUM MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-203580 MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ETOPOSIDE MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23999041

Sources:
DTC
ERLOTINIB MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26181029

Sources:
CIViC
HAEMATOXYLIN MAPK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ELLAGIC ACID MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIFLUOPERAZINE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MITOXANTRONE HYDROCHLORIDE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HYDROCHLORIDE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN HYDROCHLORIDE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-202190 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL505670 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL541400 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL35482 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MITOXANTRONE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB
GO-6976 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL429095 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROGESTERONE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 MAPK1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 MAPK1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 MAPK1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 MAPK1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000100030
- Version: 101_38
Alternate Names:

MAPK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P28482
- Version: January-2014
Alternate Names:

MAPK1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:

RussLampel: ENSG00000100030

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482] Description

ENSG00000100030 Ensembl Gene Id

MAPK1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P28482
- Version: 11-September-2012
Alternate Names:

MAPK1 Uniprot Gene Name

MK01_HUMAN Uniprot Id

ENSG00000100030 Ensembl Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5594
- Version: 29-September-2020
Alternate Names:

6871 HUGO Gene ID

6871 HUGO Gene Symbol

mitogen-activated protein kinase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name ERK subfamily

GuideToPharmacology Gene Category ID 514

Gene Categories:

ENZYME

Publications:
PharmGKB: MAPK1
- Version: 18-August-2020
Alternate Names:

PA30616 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

CIViC: MAPK1

Version: 14-September-2020

Alternate Names:

5594 Entrez Gene ID

4532 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Ercan et al., 2012, Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors., Cancer Discov

Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol

TTD: Extracellular signal-regulated kinase 2
- Version: 2020.06.01
Alternate Names:

ERK2 TTD Gene Abbreviation

T58970 TTD Target ID

Gene Info:

Publications:

Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

NCI: MAPK1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.

Imbe et al., 2005, Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla., Brain Res.

Veit et al., 2004, Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells., Cancer Res.

DTC: MAPK1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem

HingoraniCasas: ENSG00000100030
- Version: 31-May-2017
Alternate Names:

ENSG00000100030 Gene Symbol

MAPK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ERK2
- Version: chembl_23
Alternate Names:

PRKM1 GENE_SYMBOL

PRKM2 GENE_SYMBOL

MAPK1 GENE_SYMBOL

Gene Info:

Publications:
Tempus: MAPK1
- Version: 11-November-2018
Alternate Names:

MAPK1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: MAPK1
- Version: 27-Jun-2013
Alternate Names:

5594 Gene ID

ERK dGene Synonym

ERK2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
GO: MAPK1
- Version: 01-May-2021
Alternate Names:

ERK2 GO Gene Synonym

PRKM1 GO Gene Synonym

PRKM2 GO Gene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE, TRANSCRIPTION FACTOR BINDING

Publications:
Pharos: MAPK1
- Version: 01-May-2021
Alternate Names:

Mitogen-activated protein kinase 1 Gene Name

P28482 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
MskImpact: MAPK1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: MAPK1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: MAPK1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Details of the Assay for Interaction	Biochemical assay determination
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482]	Description
ENSG00000100030	Ensembl Gene Id
MAPK1	Display Id

MAPK1	Uniprot Gene Name
MK01_HUMAN	Uniprot Id
ENSG00000100030	Ensembl Gene Id

6871	HUGO Gene ID
6871	HUGO Gene Symbol
mitogen-activated protein kinase 1	HUGO Gene Name

MAPK1 Gene Record

MAPK1 5594 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 25320010

Sources: ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19835377

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22982122

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22283430

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22283430

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Biochemical assay determination Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 28939558

Sources: ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20951582

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22982122

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22982122

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20951582

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17171453

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12014623

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
25320010

Sources:
ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
19835377

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22982122

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22283430

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22283430

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Biochemical assay determination

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
28939558

Sources:
ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
20951582

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22982122

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22982122

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20951582

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17171453

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
12014623

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17076658

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found