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MAPK11 Gene Record

  • Summary
  • Interactions
  • Claims
  • MAPK11 5600 Druggable Genome

    Alternate Names:

    5600
    MITOGEN-ACTIVATED PROTEIN KINASE 11
    MAPK11
    P38B
    P38BETA2
    PRKM11
    SAPK2
    SAPK2B
    p38-2
    p38Beta
    602898
    6873
    ENSG00000185386
    OTTHUMG00000150226
    MK11_HUMAN
    Q15759
    PA30618
    MAP kinase p38 beta
    MAPK 11
    MAP kinase 11
    Stress-activated protein kinase 2b
    Mitogen-activated protein kinase p38 beta
    MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759]
    p38 beta
    T55729

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Acc IPR002290
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name KINASE
    Target Class Enzymes
    Target Subclass EC:2.7.11.24
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
    Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
    Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
    Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
    Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
    Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
    Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
  • CRYPTOLEPINE HYDROCHLORIDE   MAPK11

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23507189


    Sources:
    DTC

  • LOSMAPIMOD   MAPK11

    Interaction Score: 1.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction MAP kinase p38 beta inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIHYDROTANSHINONE I   MAPK11

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • MILTIRONE   MAPK11

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • XANTHOHUMOL   MAPK11

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22111577


    Sources:
    DTC

  • CHEMBL8483   MAPK11

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18566250


    Sources:
    DTC

  • OPHIOBOLIN O   MAPK11

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22130129


    Sources:
    DTC

  • RWJ-67657   MAPK11

    Interaction Score: 0.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction MAP kinase p38 beta inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • KERACYANIN   MAPK11

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17360708


    Sources:
    DTC

  • BMS-582949   MAPK11

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name BMS-582949
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ARRY-797   MAPK11

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ARRY-797
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RHAMNETIN   MAPK11

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24397781


    Sources:
    DTC

  • NEFLAMAPIMOD   MAPK11

    Interaction Score: 0.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PH-797804   MAPK11

    Interaction Score: 0.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PH-797804
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SEMAPIMOD   MAPK11

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name CPSI-2364
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PIRFENIDONE   MAPK11

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name pirfenidone,Esbriet , Deskar, Pirespa
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PEXMETINIB   MAPK11

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ARRY-614
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • VX-702   MAPK11

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name VX-702
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SB-203580   MAPK11

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25692815


    Sources:
    DTC

  • REGORAFENIB   MAPK11

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction MAP kinase p38 beta inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions MyCancerGenomeClinicalTrial

  • SB-202190   MAPK11

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22951114


    Sources:
    DTC

  • CI-1040   MAPK11

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SORAFENIB   MAPK11

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • Ensembl: ENSG00000185386

    • Version: 101_38

    Alternate Names:
    MAPK11 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q15759

    • Version: January-2014

    Alternate Names:
    MAPK11 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.24

    Publications:

  • RussLampel: ENSG00000185386

    • Version: 26-July-2011

    Alternate Names:
    MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759] Description
    ENSG00000185386 Ensembl Gene Id
    MAPK11 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q15759

    • Version: 11-September-2012

    Alternate Names:
    Q15759 Uniprot Accession
    5600 Entrez Gene Id
    MAPK11 Uniprot Gene Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: MAPK11

    • Version: 18-August-2020

    Alternate Names:
    PA30618 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • DTC: MAPK11

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
    Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

  • HingoraniCasas: ENSG00000185386

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000185386 Gene Symbol
    MAPK11 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: PRKM11

    • Version: chembl_23

    Alternate Names:
    SAPK2 GENE_SYMBOL
    SAPK2B GENE_SYMBOL
    MAPK11 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: MAPK11

    • Version: 01-February-2022

    Alternate Names:
    PRKM11 GO Gene Synonym
    SAPK2 GO Gene Synonym
    SAPK2B GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: MAPK11

    • Version: 27-Jun-2013

    Alternate Names:
    5600 Gene ID
    P38B dGene Synonym
    P38BETA2 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Stress-activated protein kinase 2b

    • Version: 2020.06.01

    Alternate Names:
    p38 beta TTD Gene Abbreviation
    T55729 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: MAPK11

    • Version: 01-February-2022

    Alternate Names:
    Mitogen-activated protein kinase 11 Gene Name
    Q15759 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • MyCancerGenomeClinicalTrial: MAPK11

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21