DGIdb - MAPK11 Gene Record

MAPK11 5600 Druggable Genome

Alternate Names:

5600
MITOGEN-ACTIVATED PROTEIN KINASE 11
MAPK11
P38B
P38BETA2
PRKM11
SAPK2
SAPK2B
p38-2
p38Beta
602898
6873
ENSG00000185386
OTTHUMG00000150226
MK11_HUMAN
Q15759
PA30618
MAP kinase p38 beta
MAPK 11
MAP kinase 11
Stress-activated protein kinase 2b
Mitogen-activated protein kinase p38 beta
MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759]
p38 beta
T55729

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Acc	IPR002290
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod

CRYPTOLEPINE HYDROCHLORIDE MAPK11

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23507189

Sources:
DTC
LOSMAPIMOD MAPK11

Interaction Score: 1.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIHYDROTANSHINONE I MAPK11

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
MILTIRONE MAPK11

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
XANTHOHUMOL MAPK11

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22111577

Sources:
DTC
CHEMBL8483 MAPK11

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18566250

Sources:
DTC
OPHIOBOLIN O MAPK11

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22130129

Sources:
DTC
RWJ-67657 MAPK11

Interaction Score: 0.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KERACYANIN MAPK11

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360708

Sources:
DTC
BMS-582949 MAPK11

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-582949

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
ARRY-797 MAPK11

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-797

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
RHAMNETIN MAPK11

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24397781

Sources:
DTC
NEFLAMAPIMOD MAPK11

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
PH-797804 MAPK11

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PH-797804

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
SEMAPIMOD MAPK11

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CPSI-2364

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PIRFENIDONE MAPK11

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PEXMETINIB MAPK11

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
VX-702 MAPK11

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name VX-702

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
SB-203580 MAPK11

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25692815

Sources:
DTC
REGORAFENIB MAPK11

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial
SB-202190 MAPK11

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
CI-1040 MAPK11

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SORAFENIB MAPK11

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB

Ensembl: ENSG00000185386
- Version: 101_38
Alternate Names:

MAPK11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q15759
- Version: January-2014
Alternate Names:

MAPK11 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:

RussLampel: ENSG00000185386

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759] Description

ENSG00000185386 Ensembl Gene Id

MAPK11 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q15759
- Version: 11-September-2012
Alternate Names:

Q15759 Uniprot Accession

5600 Entrez Gene Id

MAPK11 Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
PharmGKB: MAPK11
- Version: 18-August-2020
Alternate Names:

PA30618 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

DTC: MAPK11

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett

Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000185386
- Version: 31-May-2017
Alternate Names:

ENSG00000185386 Gene Symbol

MAPK11 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PRKM11
- Version: chembl_23
Alternate Names:

SAPK2 GENE_SYMBOL

SAPK2B GENE_SYMBOL

MAPK11 GENE_SYMBOL

Gene Info:

Publications:
GO: MAPK11
- Version: 01-February-2022
Alternate Names:

PRKM11 GO Gene Synonym

SAPK2 GO Gene Synonym

SAPK2B GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: MAPK11
- Version: 27-Jun-2013
Alternate Names:

5600 Gene ID

P38B dGene Synonym

P38BETA2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Stress-activated protein kinase 2b
- Version: 2020.06.01
Alternate Names:

p38 beta TTD Gene Abbreviation

T55729 TTD Target ID

Gene Info:

Publications:
Pharos: MAPK11
- Version: 01-February-2022
Alternate Names:

Mitogen-activated protein kinase 11 Gene Name

Q15759 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
MyCancerGenomeClinicalTrial: MAPK11
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	MAP kinase p38 beta inhibitor
Direct Interaction	yes

Trial Name	pirfenidone,Esbriet , Deskar, Pirespa
Novel drug target	Novel Target

MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759]	Description
ENSG00000185386	Ensembl Gene Id
MAPK11	Display Id

Q15759	Uniprot Accession
5600	Entrez Gene Id
MAPK11	Uniprot Gene Name

PRKM11	GO Gene Synonym
SAPK2	GO Gene Synonym
SAPK2B	GO Gene Synonym

Mitogen-activated protein kinase 11	Gene Name
Q15759	UniProt ID

MAPK11 Gene Record

MAPK11 5600 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23507189

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 beta inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26339922

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26339922

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22111577

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18566250

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22130129

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 beta inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17360708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-582949 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ARRY-797 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24397781

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PH-797804 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name CPSI-2364 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name pirfenidone,Esbriet , Deskar, Pirespa Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ARRY-614 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name VX-702 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
23507189

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
26339922

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26339922

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22111577

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18566250

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22130129

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17360708

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-582949

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-797

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24397781

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PH-797804

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CPSI-2364

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name VX-702

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25692815

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
22951114

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20124951

Sources:
PharmGKB

Alternate Names:

MAPK11 Ensembl Gene Name