DGIdb - MAPK11 Gene Record

MAPK11 5600 Druggable Genome

Alternate Names:

5600
MITOGEN-ACTIVATED PROTEIN KINASE 11
MAPK11
P38B
P38BETA2
PRKM11
SAPK2
SAPK2B
p38-2
p38Beta
602898
6873
ENSG00000185386
OTTHUMG00000150226
MK11_HUMAN
Q15759
PA30618
1500
NP_002742
NM_002751
MAP kinase p38 beta
MAPK 11
MAP kinase 11
Stress-activated protein kinase 2b
Mitogen-activated protein kinase p38 beta
MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759]
p38 beta
T55729

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Acc	IPR002290
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
GuideToPharmacology Gene Category Name	p38 subfamily
GuideToPharmacology Gene Category ID	519
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod

TALMAPIMOD MAPK11

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
CRYPTOLEPINE HYDROCHLORIDE MAPK11

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23507189

Sources:
DTC
LOSMAPIMOD MAPK11

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIHYDROTANSHINONE I MAPK11

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
NEFLAMAPIMOD MAPK11

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD
MILTIRONE MAPK11

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
PH-797804 MAPK11

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
XANTHOHUMOL MAPK11

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22111577

Sources:
DTC
CHEMBL8483 MAPK11

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18566250

Sources:
DTC
OPHIOBOLIN O MAPK11

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22130129

Sources:
DTC
RWJ-67657 MAPK11

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KERACYANIN MAPK11

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360708

Sources:
DTC
VX-702 MAPK11

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
BMS-582949 MAPK11

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-582949

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
ARRY-797 MAPK11

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-797

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PAMAPIMOD MAPK11

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
RHAMNETIN MAPK11

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24397781

Sources:
DTC
SEMAPIMOD MAPK11

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CPSI-2364

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PIRFENIDONE MAPK11

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PEXMETINIB MAPK11

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
SB-203580 MAPK11

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25692815

Sources:
DTC
REGORAFENIB MAPK11

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial
SB-202190 MAPK11

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
DORAMAPIMOD MAPK11

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of p38β2.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CI-1040 MAPK11

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TAK-715 MAPK11

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
SORAFENIB MAPK11

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB

Ensembl: ENSG00000185386
- Version: 101_38
Alternate Names:

MAPK11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q15759
- Version: January-2014
Alternate Names:

MAPK11 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:

RussLampel: ENSG00000185386

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759] Description

ENSG00000185386 Ensembl Gene Id

MAPK11 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q15759
- Version: 11-September-2012
Alternate Names:

Q15759 Uniprot Accession

5600 Entrez Gene Id

MAPK11 Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5600
- Version: 29-September-2020
Alternate Names:

6873 HUGO Gene ID

6873 HUGO Gene Symbol

mitogen-activated protein kinase 11 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name p38 subfamily

GuideToPharmacology Gene Category ID 519

Gene Categories:

ENZYME

Publications:
PharmGKB: MAPK11
- Version: 18-August-2020
Alternate Names:

PA30618 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

DTC: MAPK11

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett

Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000185386
- Version: 31-May-2017
Alternate Names:

ENSG00000185386 Gene Symbol

MAPK11 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PRKM11
- Version: chembl_23
Alternate Names:

SAPK2 GENE_SYMBOL

SAPK2B GENE_SYMBOL

MAPK11 GENE_SYMBOL

Gene Info:

Publications:
dGene: MAPK11
- Version: 27-Jun-2013
Alternate Names:

5600 Gene ID

P38B dGene Synonym

P38BETA2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Stress-activated protein kinase 2b
- Version: 2020.06.01
Alternate Names:

p38 beta TTD Gene Abbreviation

T55729 TTD Target ID

Gene Info:

Publications:
GO: MAPK11
- Version: 01-May-2021
Alternate Names:

PRKM11 GO Gene Synonym

SAPK2 GO Gene Synonym

SAPK2B GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Pharos: MAPK11
- Version: 01-May-2021
Alternate Names:

Mitogen-activated protein kinase 11 Gene Name

Q15759 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
MyCancerGenomeClinicalTrial: MAPK11
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Mechanism of Interaction	MAP kinase p38 beta inhibitor
Direct Interaction	yes

Details of the Assay for Interaction	In a biochemical assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Trial Name	pirfenidone,Esbriet , Deskar, Pirespa
Novel drug target	Novel Target

Details of the Assay for Interaction	Inhibition of p38β2.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

MITOGEN-ACTIVATED PROTEIN KINASE 11 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38 BETA) (MAP KINASE P38 BETA) (P38B) (P38-2) (STRESS- ACTIVATED PROTEIN KINASE-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15759]	Description
ENSG00000185386	Ensembl Gene Id
MAPK11	Display Id

Q15759	Uniprot Accession
5600	Entrez Gene Id
MAPK11	Uniprot Gene Name

6873	HUGO Gene ID
6873	HUGO Gene Symbol
mitogen-activated protein kinase 11	HUGO Gene Name

PRKM11	GO Gene Synonym
SAPK2	GO Gene Synonym
SAPK2B	GO Gene Synonym

Mitogen-activated protein kinase 11	Gene Name
Q15759	UniProt ID

MAPK11 Gene Record

MAPK11 5600 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23507189

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 beta inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26339922

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26339922

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22111577

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18566250

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22130129

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase p38 beta inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17360708

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-582949 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ARRY-797 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction In a biochemical assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24397781

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name CPSI-2364 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name pirfenidone,Esbriet , Deskar, Pirespa Novel drug target Novel Target

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23507189

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
26339922

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
26339922

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22111577

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18566250

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22130129

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17360708

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-582949

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-797

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
24397781

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CPSI-2364

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25692815

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase p38 beta inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a