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MAPK3 Gene Record

  • Summary
  • Interactions
  • Claims
  • MAPK3 5595 Druggable Genome

    Alternate Names:

    5595
    MITOGEN-ACTIVATED PROTEIN KINASE 3
    MAPK3
    ERK-1
    ERK1
    ERT2
    HS44KDAP
    HUMKER1A
    P44ERK1
    P44MAPK
    PRKM3
    p44-ERK1
    p44-MAPK
    601795
    6877
    ENSG00000102882
    OTTHUMG00000132149
    MAPK 3
    MAP kinase 3
    Extracellular signal-regulated kinase 1
    Microtubule-associated protein 2 kinase
    Insulin-stimulated MAP2 kinase
    MAP kinase isoform p44
    P27361
    PA30622
    MITOGEN-ACTIVATED PROTEIN KINASE 3 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 1) (ERK-1) (INSULIN-STIMULATED MAP2 KINASE) (MAP KINASE 1) (MAPK 1) (P44-ERK1) (ERT2) (P44-MAPK) (MICROTUBULE- ASSOCIATED PROTEIN-2 KINASE). [SOURCE:UNIPROT/SWISSPROT;
    MK03_HUMAN
    T23276

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.24
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Human Readable Name KINASE
    Interpro Acc IPR002290
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett
    Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
    Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod
    Yang CL et al., 2009, Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages., J Med Chem
    Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
    Cala O et al., 2015, Ligand-Orientation Based Fragment Selection in STD NMR Screening., J Med Chem
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther
    Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
    Ziegler et al., 2006, DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells., Ann. N. Y. Acad. Sci.
    Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res
    Yao et al., 2004, [Expression and activation of MAPK pathway signaling molecules in human breast cancer cell lines]., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
    Iliodromitis et al., 2006, Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning., Basic Res. Cardiol.
    Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
    Iacopino et al., 2006, Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells., Int. J. Oncol.
    Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem
    Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
    Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie
    Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
    Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
  • CHEMBL389685   MAPK3

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26492576


    Sources:
    DTC

  • RAVOXERTINIB   MAPK3

    Interaction Score: 2.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction MAP kinase ERK1 inhibitor

    PMIDs:
    25320010


    Sources:
    ChemblInteractions TTD

  • SPINASAPONIN A METHYL ESTER   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20951582


    Sources:
    DTC

  • CHEMBL2088731   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • CHEMBL2063681   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22283430


    Sources:
    DTC

  • PESUDOGINSENOSIDE RP1 METHYL ESTER   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20951582


    Sources:
    DTC

  • CHEMBL2063687   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22283430


    Sources:
    DTC

  • CHEMBL2088730   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • CIMIRACEMATE A   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19835377


    Sources:
    DTC

  • CHEMBL329785   MAPK3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • ULIXERTINIB   MAPK3

    Interaction Score: 1.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction MAP kinase ERK1 inhibitor
    Direct Interaction yes

    PMIDs:
    28939558


    Sources:
    ChemblInteractions TTD

  • MADOLIN T   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MADOLIN U   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ARISTOLACTONE   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2333543   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ARISTOYUNNOLIN A   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VOLVALERENAL D   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MADOLIN A   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2333548   MAPK3

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEMETHYLWEDELOLACTONE   MAPK3

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926226


    Sources:
    DTC

  • YUANHUADINE   MAPK3

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21916433


    Sources:
    DTC

  • GAMBOGIC AMIDE   MAPK3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • XANTHOHUMOL   MAPK3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22111577


    Sources:
    DTC

  • CHEMBL269881   MAPK3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OPHIOBOLIN O   MAPK3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22130129


    Sources:
    DTC

  • MK-8353   MAPK3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction MAP kinase ERK1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENETHYLISOTHIOCYANATE   MAPK3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22607231


    Sources:
    DTC

  • CHEMBL29197   MAPK3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17681471


    Sources:
    DTC

  • GAMBOGIC ACID   MAPK3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • WEDELOLACTONE   MAPK3

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926226


    Sources:
    DTC

  • NITROGLYCERIN   MAPK3

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16612556


    Sources:
    NCI

  • WITHAFERIN A   MAPK3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20726569


    Sources:
    DTC

  • COMBRETASTATIN A4   MAPK3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • PRASTERONE   MAPK3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17102100


    Sources:
    NCI

  • ANDROSTANOLONE   MAPK3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16773205


    Sources:
    NCI

  • ETOPOSIDE   MAPK3

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23999041


    Sources:
    DTC

  • CHEMBL35482   MAPK3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUERCETIN   MAPK3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17045724


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   MAPK3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15193230


    Sources:
    NCI

  • SORAFENIB   MAPK3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • Ensembl: ENSG00000102882

    • Version: 101_38

    Alternate Names:
    MAPK3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000102882

    • Version: 26-July-2011

    Alternate Names:
    MITOGEN-ACTIVATED PROTEIN KINASE 3 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 1) (ERK-1) (INSULIN-STIMULATED MAP2 KINASE) (MAP KINASE 1) (MAPK 1) (P44-ERK1) (ERT2) (P44-MAPK) (MICROTUBULE- ASSOCIATED PROTEIN-2 KINASE). [SOURCE:UNIPROT/SWISSPROT; Description
    ENSG00000102882 Ensembl Gene Id
    MAPK3 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P27361

    • Version: January-2014

    Alternate Names:
    MAPK3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.24

    Publications:

  • HopkinsGroom: P27361

    • Version: 11-September-2012

    Alternate Names:
    MAPK3 Uniprot Gene Name
    ENSG00000102882 Ensembl Gene Id
    P27361 Uniprot Accession

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: MAPK3

    • Version: 18-August-2020

    Alternate Names:
    PA30622 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • TTD: Extracellular signal-regulated kinase 1

    • Version: 2020.06.01

    Alternate Names:
    ERK1 TTD Gene Abbreviation
    T23276 TTD Target ID

    Gene Info:

    Publications:
    Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

  • NCI: MAPK3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Oh et al., 2001, Immunosuppressant rapamycin inhibits protein kinase C alpha and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis., Eur. J. Pharmacol.
    Syme et al., 2005, Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling., J. Biol. Chem.
    Conley et al., 2004, Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells., Invest. Ophthalmol. Vis. Sci.

  • DTC: MAPK3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

  • HingoraniCasas: ENSG00000102882

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000102882 Gene Symbol
    MAPK3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ERK1

    • Version: chembl_23

    Alternate Names:
    p44-MAPK UNIPROT
    PRKM3 GENE_SYMBOL
    MAPK3 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: MAPK3

    • Version: 01-February-2022

    Alternate Names:
    ERK1 GO Gene Synonym
    PRKM3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: MAPK3

    • Version: 27-Jun-2013

    Alternate Names:
    5595 Gene ID
    ERK-1 dGene Synonym
    ERK1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: MAPK3

    • Version: 01-February-2022

    Alternate Names:
    Mitogen-activated protein kinase 3 Gene Name
    P27361 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21