DGIdb - MAPK3 Gene Record

MAPK3 5595 Druggable Genome

Alternate Names:

5595
MITOGEN-ACTIVATED PROTEIN KINASE 3
MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
601795
6877
ENSG00000102882
OTTHUMG00000132149
MAPK 3
MAP kinase 3
Extracellular signal-regulated kinase 1
Microtubule-associated protein 2 kinase
Insulin-stimulated MAP2 kinase
MAP kinase isoform p44
P27361
PA30622
MITOGEN-ACTIVATED PROTEIN KINASE 3 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 1) (ERK-1) (INSULIN-STIMULATED MAP2 KINASE) (MAP KINASE 1) (MAPK 1) (P44-ERK1) (ERT2) (P44-MAPK) (MICROTUBULE- ASSOCIATED PROTEIN-2 KINASE). [SOURCE:UNIPROT/SWISSPROT;
MK03_HUMAN
1494
NP_001035145
NM_001040056
T23276

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Type	Domain
Human Readable Name	KINASE
Interpro Acc	IPR002290
GuideToPharmacology Gene Category Name	ERK subfamily
GuideToPharmacology Gene Category ID	514
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett
Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod
Yang CL et al., 2009, Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages., J Med Chem
Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
Cala O et al., 2015, Ligand-Orientation Based Fragment Selection in STD NMR Screening., J Med Chem
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther
Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
Ziegler et al., 2006, DHEA reduces NGF-mediated cell survival in serum-deprived PC12 cells., Ann. N. Y. Acad. Sci.
Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res
Yao et al., 2004, [Expression and activation of MAPK pathway signaling molecules in human breast cancer cell lines]., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Iliodromitis et al., 2006, Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning., Basic Res. Cardiol.
Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
Iacopino et al., 2006, Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells., Int. J. Oncol.
Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem
Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
Angeloni et al., 2007, Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress., Biochimie
Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod

RAVOXERTINIB MAPK3

Interaction Score: 3.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase ERK1 inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
25320010

Sources:
ChemblInteractions GuideToPharmacology TTD
CHEMBL389685 MAPK3

Interaction Score: 3.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26492576

Sources:
DTC
SPINASAPONIN A METHYL ESTER MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20951582

Sources:
DTC
CHEMBL2088731 MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
CHEMBL2063681 MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22283430

Sources:
DTC
PESUDOGINSENOSIDE RP1 METHYL ESTER MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20951582

Sources:
DTC
CHEMBL2063687 MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22283430

Sources:
DTC
ULIXERTINIB MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase ERK1 inhibitor

Direct Interaction yes

Details of the Assay for Interaction Biochemical assay determination

PMIDs:
28939558

Sources:
ChemblInteractions GuideToPharmacology TTD
CHEMBL2088730 MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
CIMIRACEMATE A MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19835377

Sources:
DTC
CHEMBL329785 MAPK3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
MK-8353 MAPK3

Interaction Score: 1.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measuring inhibition of activated ERK1 in a IMAP kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
MADOLIN T MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MADOLIN U MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ARISTOLACTONE MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2333543 MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ARISTOYUNNOLIN A MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VOLVALERENAL D MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MADOLIN A MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2333548 MAPK3

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEMETHYLWEDELOLACTONE MAPK3

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926226

Sources:
DTC
YUANHUADINE MAPK3

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21916433

Sources:
DTC
GAMBOGIC AMIDE MAPK3

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17911251

Sources:
DTC
XANTHOHUMOL MAPK3

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22111577

Sources:
DTC
CHEMBL269881 MAPK3

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OPHIOBOLIN O MAPK3

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22130129

Sources:
DTC
PHENETHYLISOTHIOCYANATE MAPK3

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22607231

Sources:
DTC
CHEMBL29197 MAPK3

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17681471

Sources:
DTC
GAMBOGIC ACID MAPK3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17911251

Sources:
DTC
NITROGLYCERIN MAPK3

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16612556

Sources:
NCI
WEDELOLACTONE MAPK3

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926226

Sources:
DTC
WITHAFERIN A MAPK3

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20726569

Sources:
DTC
COMBRETASTATIN A4 MAPK3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22982122

Sources:
DTC
PRASTERONE MAPK3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17102100

Sources:
NCI
ANDROSTANOLONE MAPK3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16773205

Sources:
NCI
ETOPOSIDE MAPK3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23999041

Sources:
DTC
CHEMBL35482 MAPK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN MAPK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17045724

Sources:
NCI
CYCLOPHOSPHAMIDE MAPK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15193230

Sources:
NCI
SORAFENIB MAPK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB

Ensembl: ENSG00000102882
- Version: 101_38
Alternate Names:

MAPK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000102882

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 3 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 1) (ERK-1) (INSULIN-STIMULATED MAP2 KINASE) (MAP KINASE 1) (MAPK 1) (P44-ERK1) (ERT2) (P44-MAPK) (MICROTUBULE- ASSOCIATED PROTEIN-2 KINASE). [SOURCE:UNIPROT/SWISSPROT; Description

ENSG00000102882 Ensembl Gene Id

MAPK3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P27361
- Version: January-2014
Alternate Names:

MAPK3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:
HopkinsGroom: P27361
- Version: 11-September-2012
Alternate Names:

MAPK3 Uniprot Gene Name

ENSG00000102882 Ensembl Gene Id

P27361 Uniprot Accession

Gene Info:

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5595
- Version: 29-September-2020
Alternate Names:

6877 HUGO Gene ID

6877 HUGO Gene Symbol

mitogen-activated protein kinase 3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name ERK subfamily

GuideToPharmacology Gene Category ID 514

Gene Categories:

ENZYME

Publications:
PharmGKB: MAPK3
- Version: 18-August-2020
Alternate Names:

PA30622 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
TTD: Extracellular signal-regulated kinase 1
- Version: 2020.06.01
Alternate Names:

ERK1 TTD Gene Abbreviation

T23276 TTD Target ID

Gene Info:

Publications:

Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

NCI: MAPK3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Oh et al., 2001, Immunosuppressant rapamycin inhibits protein kinase C alpha and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis., Eur. J. Pharmacol.

Syme et al., 2005, Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling., J. Biol. Chem.

Conley et al., 2004, Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells., Invest. Ophthalmol. Vis. Sci.

DTC: MAPK3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem

Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

HingoraniCasas: ENSG00000102882
- Version: 31-May-2017
Alternate Names:

ENSG00000102882 Gene Symbol

MAPK3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ERK1
- Version: chembl_23
Alternate Names:

p44-MAPK UNIPROT

PRKM3 GENE_SYMBOL

MAPK3 GENE_SYMBOL

Gene Info:

Publications:
dGene: MAPK3
- Version: 27-Jun-2013
Alternate Names:

5595 Gene ID

ERK-1 dGene Synonym

ERK1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
GO: MAPK3
- Version: 01-May-2021
Alternate Names:

ERK1 GO Gene Synonym

PRKM3 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Pharos: MAPK3
- Version: 01-May-2021
Alternate Names:

Mitogen-activated protein kinase 3 Gene Name

P27361 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	MAP kinase ERK1 inhibitor
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Measuring inhibition of activated ERK1 in a IMAP kinase assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

MITOGEN-ACTIVATED PROTEIN KINASE 3 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 1) (ERK-1) (INSULIN-STIMULATED MAP2 KINASE) (MAP KINASE 1) (MAPK 1) (P44-ERK1) (ERT2) (P44-MAPK) (MICROTUBULE- ASSOCIATED PROTEIN-2 KINASE). [SOURCE:UNIPROT/SWISSPROT;	Description
ENSG00000102882	Ensembl Gene Id
MAPK3	Display Id

MAPK3	Uniprot Gene Name
ENSG00000102882	Ensembl Gene Id
P27361	Uniprot Accession

6877	HUGO Gene ID
6877	HUGO Gene Symbol
mitogen-activated protein kinase 3	HUGO Gene Name

MAPK3 Gene Record

MAPK3 5595 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction MAP kinase ERK1 inhibitor Specific Action of the Ligand Inhibition

PMIDs: 25320010

Sources: ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26492576

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20951582

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22982122

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22283430

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20951582

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22283430

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction MAP kinase ERK1 inhibitor Direct Interaction yes Details of the Assay for Interaction Biochemical assay determination

PMIDs: 28939558

Sources: ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22982122

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19835377

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22982122

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Measuring inhibition of activated ERK1 in a IMAP kinase assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction MAP kinase ERK1 inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
25320010

Sources:
ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
26492576

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20951582

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22982122

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22283430

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20951582

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22283430

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction MAP kinase ERK1 inhibitor

Direct Interaction yes

Details of the Assay for Interaction Biochemical assay determination

PMIDs:
28939558

Sources:
ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
22982122

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19835377

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22982122

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measuring inhibition of activated ERK1 in a IMAP kinase assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22926226

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21916433

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17911251

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22111577

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22130129