DGIdb - MC2R Gene Record

MC2R 4158 Druggable Genome

Alternate Names:

4158
MELANOCORTIN 2 RECEPTOR
MC2R
ACTHR
607397
6930
ENSG00000185231
OTTHUMG00000131721
Q01718
ACTHR_HUMAN
MC2-R
ACTH-R
ACTH receptor
Melanocortin receptor 2
Adrenocorticotropin receptor
Adrenocorticotropic hormone receptor
283
NP_000520
NM_000529
MC<sub>2</sub> receptor
ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718]
T08898

Gene Info:

Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
GuideToPharmacology Gene Category Name	Melanocortin receptors
GuideToPharmacology Gene Category ID	38
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Lin et al., 2007, Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia., Clin. Endocrinol. (Oxf)
Carey et al., 2006, Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep., Am. J. Physiol. Endocrinol. Metab.
Hruby et al., 2007, Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor., Curr Top Med Chem
Johnston et al., 2007, Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis., Reproduction
Suri et al., 2006, A case of ACTH-independent bilateral macronodular adrenal hyperplasia and severe congestive heart failure., J. Endocrinol. Invest.
Heppner et al., Adrenocortical insufficiency in Rhodesian sleeping sickness is not attributable to suramin., Trans. R. Soc. Trop. Med. Hyg.
Schwerin et al., 2005, Stress-related gene expression in brain and adrenal gland of porcine fetuses and neonates., Theriogenology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Moraes et al., 2010, Cortisol variation after low-dose Cortrosyn test., Crit. Care Med.
Mehrabani et al., 1990, Adrenocorticotropin binding sites in rat cardiac tissue., Pharmacol. Biochem. Behav.
Pietrasiewicz et al., Studies on the interaction of antidepressant drugs with adrenocorticotropic hormone or prednisone in rats., Pol J Pharmacol
Kitamura et al., 2002, Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats., Pharmacol. Biochem. Behav.

COSYNTROPIN MC2R

Interaction Score: 71.77

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction? True

PMIDs:
15710205 11752352 20562554 2156274

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
CORTICOTROPIN ZINC HYDROXIDE MC2R

Interaction Score: 7.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
SERACTIDE ACETATE MC2R

Interaction Score: 7.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
CORTICOTROPIN MC2R

Interaction Score: 4.91

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

Trial Name -

PMIDs:
17223989 16478774 17584128 17636172 17185906

Sources:
TdgClinicalTrial ChemblInteractions TEND
CORTICOTROPIN RELEASING HORMONE MC2R

Interaction Score: 2.66

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
IMIPRAMINE MC2R

Interaction Score: 1.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11900811

Sources:
NCI
PREDNISONE MC2R

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9112644

Sources:
NCI
SURAMIN MC2R

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7747311

Sources:
NCI

Ensembl: ENSG00000185231
- Version: 101_38
Alternate Names:

MC2R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q01718
- Version: 11-September-2012
Alternate Names:

ADRENOCORTICOTROPIC HORMONE RECEPTOR Uniprot Protein Name

4158 Entrez Gene Id

MC2R Uniprot Gene Name

Gene Info:

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Type Family

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: Q01718
- Version: 01-August-2011
Alternate Names:

4158 Entrez Gene Id

Q01718 Uniprot Accession

ENSG00000185231 Ensembl Gene Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Publications:

RussLampel: ENSG00000185231

Version: 26-July-2011

Alternate Names:

MC2R Display Id

ENSG00000185231 Ensembl Gene Id

ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q01718
- Version: January-2014
Alternate Names:

MC2R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
GuideToPharmacology: 4158
- Version: 29-September-2020
Alternate Names:

6930 HUGO Gene ID

6930 HUGO Gene Symbol

melanocortin 2 receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Melanocortin receptors

GuideToPharmacology Gene Category ID 38

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

NCI: MC2R

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Heppner et al., Adrenocortical insufficiency in Rhodesian sleeping sickness is not attributable to suramin., Trans. R. Soc. Trop. Med. Hyg.

Hatjis et al., 1985, Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy., Am. J. Obstet. Gynecol.

Pietrasiewicz et al., Studies on the interaction of antidepressant drugs with adrenocorticotropic hormone or prednisone in rats., Pol J Pharmacol

HingoraniCasas: ENSG00000185231
- Version: 31-May-2017
Alternate Names:

ENSG00000185231 Gene Symbol

MC2R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ACTHR
- Version: chembl_23
Alternate Names:

MC2-R UNIPROT

ACTHR GENE_SYMBOL

MC2R GENE_SYMBOL

Gene Info:

Publications:
dGene: MC2R
- Version: 27-Jun-2013
Alternate Names:

4158 Gene ID

ACTHR dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Melanocortin receptor 2
- Version: 2020.06.01
Alternate Names:

MC2R TTD Gene Abbreviation

T08898 TTD Target ID

Gene Info:

Publications:
GO: MC2R
- Version: 01-May-2021
Alternate Names:

ACTHR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	-
Novel drug target	Established target
Direct Interaction?	True

Direct Interaction	yes
Mechanism of Interaction	Melanocortin receptor 2 agonist

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	True

ADRENOCORTICOTROPIC HORMONE RECEPTOR	Uniprot Protein Name
4158	Entrez Gene Id
MC2R	Uniprot Gene Name

MC2R	Display Id
ENSG00000185231	Ensembl Gene Id
ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718]	Description

6930	HUGO Gene ID
6930	HUGO Gene Symbol
melanocortin 2 receptor	HUGO Gene Name

agonist (activating)
antagonist (inhibitory)

MC2R Gene Record

MC2R 4158 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction? True

PMIDs: 15710205 11752352 20562554 2156274

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Melanocortin receptor 2 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Melanocortin receptor 2 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Melanocortin receptor 2 agonist Trial Name -

PMIDs: 17223989 16478774 17584128 17636172 17185906

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11900811

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9112644

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7747311

Sources: NCI

Ensembl: ENSG00000185231

Alternate Names: MC2R Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q01718

Alternate Names: ADRENOCORTICOTROPIC HORMONE RECEPTOR Uniprot Protein Name 4158 Entrez Gene Id MC2R Uniprot Gene Name

Gene Info: Interpro Short Name 7TM_GPCR_Rhodpsn Interpro Type Family Human Readable Name DRUGGABLE GENOME

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

TEND: Q01718

Alternate Names: 4158 Entrez Gene Id Q01718 Uniprot Accession ENSG00000185231 Ensembl Gene Id

Gene Info: Transmembrane Helix Count 7 Target Subclass Rhodopsin Target Main Class Receptors

Publications:

RussLampel: ENSG00000185231

Alternate Names: MC2R Display Id ENSG00000185231 Ensembl Gene Id ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q01718

Alternate Names: MC2R Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

GuideToPharmacology: 4158

Alternate Names: 6930 HUGO Gene ID 6930 HUGO Gene Symbol melanocortin 2 receptor HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Melanocortin receptors GuideToPharmacology Gene Category ID 38

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

NCI: MC2R

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000185231

Alternate Names: ENSG00000185231 Gene Symbol MC2R Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ACTHR

Alternate Names: MC2-R UNIPROT ACTHR GENE_SYMBOL MC2R GENE_SYMBOL

Gene Info:

Publications:

dGene: MC2R

Alternate Names: 4158 Gene ID ACTHR dGene Synonym

Gene Info:

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction? True

PMIDs:
15710205 11752352 20562554 2156274

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

Trial Name -

PMIDs:
17223989 16478774 17584128 17636172 17185906

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11900811

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9112644

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7747311

Sources:
NCI

Alternate Names:

MC2R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ADRENOCORTICOTROPIC HORMONE RECEPTOR Uniprot Protein Name

4158 Entrez Gene Id

MC2R Uniprot Gene Name

Gene Info:

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Type Family

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

4158 Entrez Gene Id

Q01718 Uniprot Accession

ENSG00000185231 Ensembl Gene Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Alternate Names:

MC2R Display Id

ENSG00000185231 Ensembl Gene Id

ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MC2R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

6930 HUGO Gene ID

6930 HUGO Gene Symbol

melanocortin 2 receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Melanocortin receptors

GuideToPharmacology Gene Category ID 38

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

ENSG00000185231 Gene Symbol

MC2R Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MC2-R UNIPROT

ACTHR GENE_SYMBOL

MC2R GENE_SYMBOL

Alternate Names:

4158 Gene ID

ACTHR dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

MC2R TTD Gene Abbreviation

T08898 TTD Target ID

Alternate Names:

ACTHR GO Gene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR