• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

MC2R Gene Record

  • Summary
  • Interactions
  • Claims
  • MC2R 4158 Druggable Genome

    Alternate Names:

    4158
    MELANOCORTIN 2 RECEPTOR
    MC2R
    ACTHR
    607397
    6930
    ENSG00000185231
    OTTHUMG00000131721
    Q01718
    ACTHR_HUMAN
    BE0000848
    MC2-R
    ACTH-R
    ACTH receptor
    Melanocortin receptor 2
    Adrenocorticotropin receptor
    Adrenocorticotropic hormone receptor
    283
    NP_000520
    NM_000529
    MC<sub>2</sub> receptor
    ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718]
    T08898

    Gene Info:

    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Target Subclass GPCR
    GuideToPharmacology Gene Category Name Melanocortin receptors
    GuideToPharmacology Gene Category ID 38
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Target Class Receptors
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Suri et al., 2006, A case of ACTH-independent bilateral macronodular adrenal hyperplasia and severe congestive heart failure., J. Endocrinol. Invest.
    Johnston et al., 2007, Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis., Reproduction
    Hruby et al., 2007, Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor., Curr Top Med Chem
    Lin et al., 2007, Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia., Clin. Endocrinol. (Oxf)
    Carey et al., 2006, Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep., Am. J. Physiol. Endocrinol. Metab.
    Heppner et al., Adrenocortical insufficiency in Rhodesian sleeping sickness is not attributable to suramin., Trans. R. Soc. Trop. Med. Hyg.
    Moraes et al., 2010, Cortisol variation after low-dose Cortrosyn test., Crit. Care Med.
    Mehrabani et al., 1990, Adrenocorticotropin binding sites in rat cardiac tissue., Pharmacol. Biochem. Behav.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Schwerin et al., 2005, Stress-related gene expression in brain and adrenal gland of porcine fetuses and neonates., Theriogenology
    Pietrasiewicz et al., Studies on the interaction of antidepressant drugs with adrenocorticotropic hormone or prednisone in rats., Pol J Pharmacol
    Kitamura et al., 2002, Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats., Pharmacol. Biochem. Behav.
  • COSYNTROPIN   MC2R

    Interaction Score: 63.12

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction? True

    PMIDs:
    20562554 2156274 11752352 15710205


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • SERACTIDE ACETATE   MC2R

    Interaction Score: 12.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Melanocortin receptor 2 agonist

    PMIDs:
    None found


    Sources:
    DrugBank ChemblInteractions

  • CORTICOTROPIN ZINC HYDROXIDE   MC2R

    Interaction Score: 6.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Melanocortin receptor 2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CORTICOTROPIN   MC2R

    Interaction Score: 4.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Melanocortin receptor 2 agonist
    Trial Name -

    PMIDs:
    17185906 17636172 17584128 17223989 16478774


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • CORTICOTROPIN RELEASING HORMONE   MC2R

    Interaction Score: 2.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BREMELANOTIDE   MC2R

    Interaction Score: 1.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • IMIPRAMINE   MC2R

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11900811


    Sources:
    NCI

  • PREDNISONE   MC2R

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9112644


    Sources:
    NCI

  • SURAMIN   MC2R

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7747311


    Sources:
    NCI

  • Ensembl: ENSG00000185231

    • Version: 101_38

    Alternate Names:
    MC2R Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q01718

    • Version: 11-September-2012

    Alternate Names:
    ADRENOCORTICOTROPIC HORMONE RECEPTOR Uniprot Protein Name
    4158 Entrez Gene Id
    MC2R Uniprot Gene Name

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: Q01718

    • Version: 01-August-2011

    Alternate Names:
    4158 Entrez Gene Id
    Q01718 Uniprot Accession
    ENSG00000185231 Ensembl Gene Id

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors

    Publications:

  • RussLampel: ENSG00000185231

    • Version: 26-July-2011

    Alternate Names:
    MC2R Display Id
    ENSG00000185231 Ensembl Gene Id
    ADRENOCORTICOTROPIC HORMONE RECEPTOR (ACTH RECEPTOR) (ACTH-R) (MELANOCORTIN-2 RECEPTOR) (MC2-R) (ADRENOCORTICOTROPIN RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01718] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q01718

    • Version: January-2014

    Alternate Names:
    MC2R Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • GuideToPharmacology: 4158

    • Version: 29-September-2020

    Alternate Names:
    6930 HUGO Gene ID
    6930 HUGO Gene Symbol
    melanocortin 2 receptor HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Melanocortin receptors
    GuideToPharmacology Gene Category ID 38

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0000848

    • Version: 5.1.7

    Alternate Names:
    MC2R DrugBank Gene Name
    Q01718 UniProt Accession
    4158 Entrez Gene Id

    Gene Info:

    Publications:
    Moraes et al., 2010, Cortisol variation after low-dose Cortrosyn test., Crit. Care Med.
    Mehrabani et al., 1990, Adrenocorticotropin binding sites in rat cardiac tissue., Pharmacol. Biochem. Behav.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • NCI: MC2R

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Heppner et al., Adrenocortical insufficiency in Rhodesian sleeping sickness is not attributable to suramin., Trans. R. Soc. Trop. Med. Hyg.
    Hatjis et al., 1985, Effect of treatment with sodium valproate on plasma adrenocorticotropic hormone and cortisol concentrations in pregnancy., Am. J. Obstet. Gynecol.
    Pietrasiewicz et al., Studies on the interaction of antidepressant drugs with adrenocorticotropic hormone or prednisone in rats., Pol J Pharmacol

  • HingoraniCasas: ENSG00000185231

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000185231 Gene Symbol
    MC2R Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ACTHR

    • Version: chembl_23

    Alternate Names:
    MC2-R UNIPROT
    ACTHR GENE_SYMBOL
    MC2R GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: MC2R

    • Version: 05-September-2020

    Alternate Names:
    ACTHR GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: MC2R

    • Version: 27-Jun-2013

    Alternate Names:
    4158 Gene ID
    ACTHR dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Melanocortin receptor 2

    • Version: 2020.06.01

    Alternate Names:
    MC2R TTD Gene Abbreviation
    T08898 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21