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MC4R Gene Record

  • Summary
  • Interactions
  • Claims
  • MC4R 4160 Druggable Genome

    Alternate Names:

    4160
    MELANOCORTIN 4 RECEPTOR
    MC4R
    155541
    6932
    ENSG00000166603
    OTTHUMG00000132766
    MC4-R
    Melanocortin receptor 4
    MELANOCORTIN-4 RECEPTOR (MC4-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P32245]
    P32245
    MC4R_HUMAN
    PA30676
    T72458
    -
    BMIQ20

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Zhang JP et al., 2016, Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis., Schizophr Bull
    Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
    Chowdhury NI et al., 2013, Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene., Pharmacogenomics J
  • SETMELANOTIDE   MC4R

    Interaction Score: 7.73

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Melanocortin receptor 4 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PF-00446687   MC4R

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Melanocortin receptor 4 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMYLIN   MC4R

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BREMELANOTIDE   MC4R

    Interaction Score: 2.9

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Bremelanotide
    Novel drug target Novel Target
    Mechanism of Interaction Melanocortin receptor 4 agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • AMISULPRIDE   MC4R

    Interaction Score: 2.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • PALIPERIDONE   MC4R

    Interaction Score: 2.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • ARIPIPRAZOLE   MC4R

    Interaction Score: 1.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • ZIPRASIDONE   MC4R

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • QUETIAPINE   MC4R

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • CLOZAPINE   MC4R

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560 22310352


    Sources:
    PharmGKB

  • CHEMBL578944   MC4R

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RISPERIDONE   MC4R

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • OLANZAPINE   MC4R

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560 22310352


    Sources:
    PharmGKB

  • HALOPERIDOL   MC4R

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • SORAFENIB TOSYLATE   MC4R

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORHEXIDINE   MC4R

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000166603

    • Version: 101_38

    Alternate Names:
    MC4R Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000166603

    • Version: 26-July-2011

    Alternate Names:
    MELANOCORTIN-4 RECEPTOR (MC4-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P32245] Description
    MC4R Display Id
    ENSG00000166603 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P32245

    • Version: 11-September-2012

    Alternate Names:
    P32245 Uniprot Accession
    MC4R_HUMAN Uniprot Id
    4160 Entrez Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P32245

    • Version: January-2014

    Alternate Names:
    MC4R Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • PharmGKB: MC4R

    • Version: 18-August-2020

    Alternate Names:
    PA30676 PharmGKB ID

    Gene Info:

    Publications:
    Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol

  • ChemblInteractions: MC4R

    • Version: chembl_23

    Alternate Names:
    MC4R GENE_SYMBOL
    Melanocortin receptor 4 UNIPROT
    MC4-R UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000166603

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000166603 Gene Symbol
    MC4R Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: MC4R

    • Version: 19.3

    Alternate Names:
    ENSG00000166603 Ensembl Gene ID
    Melanocortin 4 receptor Human Protein Atlas Gene Description
    P32245 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER, G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: MC4R

    • Version: 27-Jun-2013

    Alternate Names:
    4160 Gene ID
    - dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Melanocortin receptor 4

    • Version: 2020.06.01

    Alternate Names:
    MC4R TTD Gene Abbreviation
    T72458 TTD Target ID

    Gene Info:

    Publications:

  • DTC: MC4R

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: MC4R

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21