• MKNK1 8569 Druggable GenomeClinically Actionable

    Alternate Names:

    8569
    MAP KINASE INTERACTING SERINE/THREONINE KINASE 1
    MKNK1
    MNK1
    606724
    7110
    ENSG00000079277
    OTTHUMG00000007983
    2104
    Q9BUB5
    MKNK1_HUMAN
    MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
    NP_001129025
    NM_001135553
    MAP KINASE-INTERACTING SERINE/THREONINE KINASE 1 (EC 2.7.1.37) (MAP KINASE SIGNAL-INTEGRATING KINASE 1) (MNK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9BUB5]
    MAPK interacting serine/threonine kinase 1
    MAPK signal-integrating kinase 1
    T97136

    Gene Info:

    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE
    Interpro Type Domain
    Interpro Acc IPR002290
    GuideToPharmacology Gene Category Name MKN subfamily
    GuideToPharmacology Gene Category ID 513
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 42.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25800647


    Sources:
    DTC

  • Interaction Score: 8.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Biochemical inhibition assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    MKNK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000079277 Ensembl Gene Id
    MKNK1 Display Id
    MAP KINASE-INTERACTING SERINE/THREONINE KINASE 1 (EC 2.7.1.37) (MAP KINASE SIGNAL-INTEGRATING KINASE 1) (MNK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9BUB5] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    MKNK1 Uniprot Gene Name
    ENSG00000079277 Ensembl Gene Id
    MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1 Uniprot Protein Name

    Gene Info:
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    7110 HUGO Gene ID
    7110 HUGO Gene Symbol
    MAPK interacting serine/threonine kinase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name MKN subfamily
    GuideToPharmacology Gene Category ID 513

    Gene Categories:
    ENZYME

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000079277 Gene Symbol
    MKNK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    8569 Gene ID
    MNK1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    MKNK1 TTD Gene Abbreviation
    T97136 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    MNK1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    MAP kinase-interacting serine/threonine-protein kinase 1 Gene Name
    Q9BUB5 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: