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MMP1 Gene Record

  • Summary
  • Interactions
  • Claims
  • MMP1 4312 Druggable Genome

    Alternate Names:

    4312
    MATRIX METALLOPEPTIDASE 1
    MMP1
    CLG
    CLGN
    120353
    7155
    ENSG00000196611
    OTTHUMG00000048192
    P03956
    MMP1_HUMAN
    27 KDA INTERSTITIAL COLLAGENASE
    INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) (MATRIX METALLOPROTEINASE-1) (MMP-1) (FIBROBLAST COLLAGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P03956]
    INTERSTITIAL COLLAGENASE
    FIBROBLAST COLLAGENASE
    MMP-1
    MATRIX METALLOPROTEINASE-1
    22 kDa interstitial collagenase
    T52450

    Gene Info:

    Interpro Short Name Peptidase_Metallo
    Interpro Name Peptidase, metallopeptidase
    Human Readable Name PROTEASE
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR006026
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:3.4.24.7
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Guido et al., 2006, Effects of interferon plus ribavirin treatment on NF-kappaB, TGF-beta1, and metalloproteinase activity in chronic hepatitis C., Mod. Pathol.
    Flisiak et al., 2004, Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B., World J. Gastroenterol.
    Delany et al., 1995, Cortisol increases interstitial collagenase expression in osteoblasts by post-transcriptional mechanisms., J. Biol. Chem.
    Heath et al., 2000, Clinical potential of matrix metalloprotease inhibitors in cancer therapy., Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Belotti et al., MMP inhibitors: experimental and clinical studies., Int. J. Biol. Markers
    Kullich et al., Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis., Clin. Exp. Rheumatol.
    Nethery et al., 1992, The chondroprotective drugs, Arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro., Biochem. Pharmacol.
    Fitton et al., 1998, Assessment of anticollagenase treatments after insertion of a keratoprosthetic material in the rabbit cornea., Cornea
    Dou et al., 1997, Differential expression of matrix metalloproteinases and their tissue inhibitors in leiomyomata: a mechanism for gonadotrophin releasing hormone agonist-induced tumour regression., Mol. Hum. Reprod.
    Sadowski et al., 2002, Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes., Biochem. Pharmacol.
    Poulalhon et al., 2006, Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent?, J. Biol. Chem.
  • LEUPROLIDE ACETATE   MMP1

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9433928


    Sources:
    NCI

  • PENTOSAN POLYSULFATE SODIUM   MMP1

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1384503


    Sources:
    NCI

  • MARIMASTAT   MMP1

    Interaction Score: 2.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10852638 11752352 10669951


    Sources:
    TTD

  • CIPEMASTAT   MMP1

    Interaction Score: 1.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • APRATASTAT   MMP1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DOXYCYCLINE   MMP1

    Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Matrix metalloproteinase-1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOXYCYCLINE CALCIUM   MMP1

    Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEFLUNOMIDE   MMP1

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16762150


    Sources:
    NCI

  • MEDROXYPROGESTERONE ACETATE   MMP1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9436888


    Sources:
    NCI

  • PRINOMASTAT   MMP1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DOXYCYCLINE HYCLATE   MMP1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Matrix metalloproteinase-1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIAMCINOLONE   MMP1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12123742


    Sources:
    NCI

  • LAMIVUDINE   MMP1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15309715


    Sources:
    NCI

  • RIBAVIRIN   MMP1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16699498


    Sources:
    NCI

  • HYDROCORTISONE   MMP1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7592884


    Sources:
    NCI

  • SIROLIMUS   MMP1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16914544


    Sources:
    NCI

  • COLLAGENASE CLOSTRIDIUM HISTOLYTICUM   MMP1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Cordase
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000196611

    • Version: 101_38

    Alternate Names:
    MMP1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P03956

    • Version: 11-September-2012

    Alternate Names:
    27 KDA INTERSTITIAL COLLAGENASE Uniprot Protein Name
    MMP1_HUMAN Uniprot Id
    P03956 Uniprot Accession

    Gene Info:
    Interpro Short Name Peptidase_Metallo
    Interpro Name Peptidase, metallopeptidase
    Human Readable Name PROTEASE

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000196611

    • Version: 26-July-2011

    Alternate Names:
    MMP1 Display Id
    INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) (MATRIX METALLOPROTEINASE-1) (MMP-1) (FIBROBLAST COLLAGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P03956] Description
    ENSG00000196611 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P03956

    • Version: January-2014

    Alternate Names:
    MMP1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.24.7

    Publications:

  • NCI: MMP1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Dou et al., 1997, Differential expression of matrix metalloproteinases and their tissue inhibitors in leiomyomata: a mechanism for gonadotrophin releasing hormone agonist-induced tumour regression., Mol. Hum. Reprod.
    Luo et al., 2005, Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases., Biomaterials
    Sadowski et al., 2002, Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes., Biochem. Pharmacol.

  • ChemblInteractions: CLG

    • Version: chembl_23

    Alternate Names:
    CLG GENE_SYMBOL
    MMP1 GENE_SYMBOL
    Interstitial collagenase UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000196611

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196611 Gene Symbol
    MMP1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: MMP1

    • Version: 01-February-2022

    Alternate Names:
    CLG GO Gene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • dGene: MMP1

    • Version: 27-Jun-2013

    Alternate Names:
    4312 Gene ID
    CLG dGene Synonym
    CLGN dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Matrix metalloproteinase-1

    • Version: 2020.06.01

    Alternate Names:
    MMP-1 TTD Gene Abbreviation
    T52450 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21