DGIdb - MMP1 Gene Record

MMP1 4312 Druggable Genome

Alternate Names:

4312
MATRIX METALLOPEPTIDASE 1
MMP1
CLG
CLGN
120353
7155
ENSG00000196611
OTTHUMG00000048192
P03956
MMP1_HUMAN
27 KDA INTERSTITIAL COLLAGENASE
1628
INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) (MATRIX METALLOPROTEINASE-1) (MMP-1) (FIBROBLAST COLLAGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P03956]
NP_002412
NM_002421
INTERSTITIAL COLLAGENASE
FIBROBLAST COLLAGENASE
MMP-1
MATRIX METALLOPROTEINASE-1
22 kDa interstitial collagenase
T52450

Gene Info:

Interpro Short Name	Peptidase_Metallo
Interpro Name	Peptidase, metallopeptidase
Human Readable Name	PROTEASE
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR006026
Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:3.4.24.7
GuideToPharmacology Gene Category Name	M10: Matrix metallopeptidase
GuideToPharmacology Gene Category ID	738
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Guido et al., 2006, Effects of interferon plus ribavirin treatment on NF-kappaB, TGF-beta1, and metalloproteinase activity in chronic hepatitis C., Mod. Pathol.
Flisiak et al., 2004, Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B., World J. Gastroenterol.
Delany et al., 1995, Cortisol increases interstitial collagenase expression in osteoblasts by post-transcriptional mechanisms., J. Biol. Chem.
Heath et al., 2000, Clinical potential of matrix metalloprotease inhibitors in cancer therapy., Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Belotti et al., MMP inhibitors: experimental and clinical studies., Int. J. Biol. Markers
Kullich et al., Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis., Clin. Exp. Rheumatol.
Nethery et al., 1992, The chondroprotective drugs, Arteparon and sodium pentosan polysulphate, increase collagenase activity and inhibit stromelysin activity in vitro., Biochem. Pharmacol.
Fitton et al., 1998, Assessment of anticollagenase treatments after insertion of a keratoprosthetic material in the rabbit cornea., Cornea
Dou et al., 1997, Differential expression of matrix metalloproteinases and their tissue inhibitors in leiomyomata: a mechanism for gonadotrophin releasing hormone agonist-induced tumour regression., Mol. Hum. Reprod.
Sadowski et al., 2002, Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes., Biochem. Pharmacol.
Poulalhon et al., 2006, Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent?, J. Biol. Chem.

LEUPROLIDE ACETATE MMP1

Interaction Score: 3.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9433928

Sources:
NCI
PENTOSAN POLYSULFATE SODIUM MMP1

Interaction Score: 3.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1384503

Sources:
NCI
CIPEMASTAT MMP1

Interaction Score: 3.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD
MARIMASTAT MMP1

Interaction Score: 2.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10852638 11752352 10669951

Sources:
GuideToPharmacology TTD
APRATASTAT MMP1

Interaction Score: 2.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD
BATIMASTAT MMP1

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
DOXYCYCLINE MMP1

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOXYCYCLINE CALCIUM MMP1

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
LEFLUNOMIDE MMP1

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16762150

Sources:
NCI
MEDROXYPROGESTERONE ACETATE MMP1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9436888

Sources:
NCI
PRINOMASTAT MMP1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DOXYCYCLINE HYCLATE MMP1

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CGS-27023A MMP1

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
TRIAMCINOLONE MMP1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12123742

Sources:
NCI
ILOMASTAT MMP1

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
LAMIVUDINE MMP1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15309715

Sources:
NCI
RIBAVIRIN MMP1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16699498

Sources:
NCI
HYDROCORTISONE MMP1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7592884

Sources:
NCI
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM MMP1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Cordase

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SIROLIMUS MMP1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16914544

Sources:
NCI

Ensembl: ENSG00000196611
- Version: 101_38
Alternate Names:

MMP1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P03956
- Version: 11-September-2012
Alternate Names:

27 KDA INTERSTITIAL COLLAGENASE Uniprot Protein Name

MMP1_HUMAN Uniprot Id

P03956 Uniprot Accession

Gene Info:

Interpro Short Name Peptidase_Metallo

Interpro Name Peptidase, metallopeptidase

Human Readable Name PROTEASE

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000196611

Version: 26-July-2011

Alternate Names:

MMP1 Display Id

INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) (MATRIX METALLOPROTEINASE-1) (MMP-1) (FIBROBLAST COLLAGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P03956] Description

ENSG00000196611 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P03956
- Version: January-2014
Alternate Names:

MMP1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.24.7

Publications:
GuideToPharmacology: 4312
- Version: 29-September-2020
Alternate Names:

7155 HUGO Gene ID

7155 HUGO Gene Symbol

matrix metallopeptidase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name M10: Matrix metallopeptidase

GuideToPharmacology Gene Category ID 738

Gene Categories:

ENZYME

Publications:

NCI: MMP1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Dou et al., 1997, Differential expression of matrix metalloproteinases and their tissue inhibitors in leiomyomata: a mechanism for gonadotrophin releasing hormone agonist-induced tumour regression., Mol. Hum. Reprod.

Luo et al., 2005, Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases., Biomaterials

Sadowski et al., 2002, Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes., Biochem. Pharmacol.

ChemblInteractions: CLG
- Version: chembl_23
Alternate Names:

CLG GENE_SYMBOL

MMP1 GENE_SYMBOL

Interstitial collagenase UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000196611
- Version: 31-May-2017
Alternate Names:

ENSG00000196611 Gene Symbol

MMP1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: MMP1
- Version: 27-Jun-2013
Alternate Names:

4312 Gene ID

CLG dGene Synonym

CLGN dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Matrix metalloproteinase-1
- Version: 2020.06.01
Alternate Names:

MMP-1 TTD Gene Abbreviation

T52450 TTD Target ID

Gene Info:

Publications:
GO: MMP1
- Version: 01-May-2021
Alternate Names:

CLG GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Mechanism of Interaction	Matrix metalloproteinase-1 inhibitor
Direct Interaction	yes

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

27 KDA INTERSTITIAL COLLAGENASE	Uniprot Protein Name
MMP1_HUMAN	Uniprot Id
P03956	Uniprot Accession

MMP1	Display Id
INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) (MATRIX METALLOPROTEINASE-1) (MMP-1) (FIBROBLAST COLLAGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P03956]	Description
ENSG00000196611	Ensembl Gene Id

7155	HUGO Gene ID
7155	HUGO Gene Symbol
matrix metallopeptidase 1	HUGO Gene Name

CLG	GENE_SYMBOL
MMP1	GENE_SYMBOL
Interstitial collagenase	UNIPROT

MMP1 Gene Record

MMP1 4312 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9433928

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1384503

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 10852638 11752352 10669951

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Matrix metalloproteinase-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16762150

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9436888

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Matrix metalloproteinase-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12123742

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15309715

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16699498

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7592884

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Cordase Novel drug target Established target

Interaction Types & Directionality:

n/a

PMIDs:
9433928

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1384503

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10852638 11752352 10669951

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16762150

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9436888

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Matrix metalloproteinase-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
12123742

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
15309715

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16699498

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7592884

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Cordase

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16914544

Sources:
NCI

Alternate Names:

MMP1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

27 KDA INTERSTITIAL COLLAGENASE Uniprot Protein Name

MMP1_HUMAN Uniprot Id

P03956 Uniprot Accession

Gene Info:

Interpro Short Name Peptidase_Metallo

Interpro Name Peptidase, metallopeptidase

Human Readable Name PROTEASE

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

MMP1 Display Id

INTERSTITIAL COLLAGENASE PRECURSOR (EC 3.4.24.7) (MATRIX METALLOPROTEINASE-1) (MMP-1) (FIBROBLAST COLLAGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P03956] Description

ENSG00000196611 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MMP1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.24.7