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MMP3 Gene Record

  • Summary
  • Interactions
  • Claims
  • MMP3 4314 Druggable Genome

    Alternate Names:

    4314
    MATRIX METALLOPEPTIDASE 3
    MMP3
    CHDS6
    MMP-3
    SL-1
    STMY
    STMY1
    STR1
    185250
    7173
    ENSG00000149968
    OTTHUMG00000048254
    P08254
    STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08254]
    STROMELYSIN-1
    MATRIX METALLOPROTEINASE-3
    ENSG00000149968; ENSG00000263313
    MMP3_HUMAN
    ENSG00000263313
    PA30886
    T86702

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name PROTEASE
    Target Main Class Enzymes
    Target Subclass 3.4.24.17
    Interpro Short Name Peptidase_Metallo
    Interpro Type Domain
    Interpro Name Peptidase, metallopeptidase
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR006026
    Target Class Enzymes
    Target Subclass EC:3.4.24.17
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    NEUTRAL ZINC METALLOPEPTIDASE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol
    Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod
  • BERKELEYTRIONE   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYDIONE   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYAMIDE B   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18330993


    Sources:
    DTC

  • BERKELEYACETAL C   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYAMIDE C   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18330993


    Sources:
    DTC

  • BERKELEYACETAL B   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYACETAL A   MMP3

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • MARIMASTAT   MMP3

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Novel Target

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial TEND

  • CHLORTHALIDONE   MMP3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PRINOMASTAT   MMP3

    Interaction Score: 0.74

    Interaction Types & Directionality:
    vaccine (activating)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • LISINOPRIL   MMP3

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PRAVASTATIN   MMP3

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10190398


    Sources:
    PharmGKB

  • Ensembl: ENSG00000149968

    • Version: 101_38

    Alternate Names:
    MMP3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P08254

    • Version: 11-September-2012

    Alternate Names:
    MMP3 Uniprot Gene Name
    MMP3_HUMAN Uniprot Id
    ENSG00000149968 Ensembl Gene Id

    Gene Info:
    Interpro Short Name Peptidase_Metallo
    Interpro Type Domain
    Interpro Name Peptidase, metallopeptidase

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • TEND: P08254

    • Version: 01-August-2011

    Alternate Names:
    4314 Entrez Gene Id
    ENSG00000149968; ENSG00000263313 Ensembl Gene Id
    MMP3 Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.4.24.17

    Publications:

  • RussLampel: ENSG00000149968

    • Version: 26-July-2011

    Alternate Names:
    STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08254] Description
    MMP3 Display Id
    ENSG00000149968 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P08254

    • Version: January-2014

    Alternate Names:
    MMP3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.24.17

    Publications:

  • PharmGKB: MMP3

    • Version: 18-August-2020

    Alternate Names:
    PA30886 PharmGKB ID

    Gene Info:

    Publications:
    de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol

  • DTC: MMP3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
    Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

  • TALC: MMP3

    • Version: 12-May-2016

    Alternate Names:
    MMP3 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000149968

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000149968 Gene Symbol
    MMP3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: MMP3

    • Version: 01-February-2022

    Alternate Names:
    STMY1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NEUTRAL ZINC METALLOPEPTIDASE, PROTEASE

    Publications:

  • dGene: MMP3

    • Version: 27-Jun-2013

    Alternate Names:
    4314 Gene ID
    CHDS6 dGene Synonym
    MMP-3 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Matrix metalloproteinase-3

    • Version: 2020.06.01

    Alternate Names:
    MMP-3 TTD Gene Abbreviation
    T86702 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: MMP3

    • Version: 01-February-2022

    Alternate Names:
    Stromelysin-1 Gene Name
    P08254 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21