DGIdb - MMP3 Gene Record

MMP3 4314 Druggable Genome

Alternate Names:

4314
MATRIX METALLOPEPTIDASE 3
MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
185250
7173
ENSG00000149968
OTTHUMG00000048254
1630
P08254
STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08254]
TTDC00105
MATRIX METALLOPROTEINASE 3
STROMELYSIN-1
MATRIX METALLOPROTEINASE-3
TRANSIN-1
ENSG00000149968; ENSG00000263313
BE0001116
NP_002413
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
NM_002422
MMP3_HUMAN
ENSG00000263313
PA30886
T86702

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	PROTEASE
GuideToPharmacology Gene Category Name	M10: Matrix metallopeptidase
GuideToPharmacology Gene Category ID	738
GuideToPharmacology Gene Type	enzyme
Target Main Class	Enzymes
Target Subclass	3.4.24.17
Interpro Short Name	Peptidase_Metallo
Interpro Type	Domain
Interpro Name	Peptidase, metallopeptidase
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR006026
Target Class	Enzymes
Target Subclass	EC:3.4.24.17
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

NEUTRAL ZINC METALLOPEPTIDASE
PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol
Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

CGS-27023A MMP3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
chembl:CHEMBL117225 MMP3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:
MARIMASTAT MMP3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Novel Target

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
PRINOMASTAT MMP3

Interaction Types & Directionality:

vaccine (activating)

Interaction Info:

Notes

Publications:
BERKELEYACETAL A MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
3-METHYLPYRIDINE MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
PRAVASTATIN MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol
BERKELEYACETAL B MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
BERKELEYAMIDE C MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod
BERKELEYACETAL C MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
BERKELEYAMIDE B MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod
BERKELEYDIONE MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
BERKELEYTRIONE MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
chembl:CHEMBL42420 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL306412 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL290140 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LISINOPRIL MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
FUTOENONE MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL470194 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL288896 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL72511 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHLORTHALIDONE MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL249847 MMP3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000149968
- Version: 101_38
Alternate Names:

MMP3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P08254
- Version: 11-September-2012
Alternate Names:

MMP3 Uniprot Gene Name

MMP3_HUMAN Uniprot Id

ENSG00000149968 Ensembl Gene Id

Gene Info:

Interpro Short Name Peptidase_Metallo

Interpro Type Domain

Interpro Name Peptidase, metallopeptidase

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
GuideToPharmacologyGenes: 1630
- Version: 4-March-2015
Alternate Names:

matrix metallopeptidase 3 (stromelysin 1, progelatinase) HUGO Gene Name

7173 HUGO Gene ID

MMP3 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name M10: Matrix metallopeptidase

GuideToPharmacology Gene Category ID 738

GuideToPharmacology Gene Type enzyme

Gene Categories:

PROTEASE, NEUTRAL ZINC METALLOPEPTIDASE

Publications:
TEND: P08254
- Version: 01-August-2011
Alternate Names:

4314 Entrez Gene Id

ENSG00000149968; ENSG00000263313 Ensembl Gene Id

MMP3 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 3.4.24.17

Publications:

RussLampel: ENSG00000149968

Version: 26-July-2011

Alternate Names:

STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08254] Description

MMP3 Display Id

ENSG00000149968 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P08254
- Version: January-2014
Alternate Names:

MMP3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.24.17

Publications:
PharmGKB: MMP3
- Version: 18-August-2020
Alternate Names:

PA30886 PharmGKB ID

Gene Info:

Publications:

de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol

DrugBank: BE0001116

Version: 5.1.7

Alternate Names:

MMP3 DrugBank Gene Name

P08254 UniProt Accession

4314 Entrez Gene Id

Gene Info:

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DTC: MMP3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

TALC: MMP3
- Version: 12-May-2016
Alternate Names:

MMP3 Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000149968
- Version: 31-May-2017
Alternate Names:

ENSG00000149968 Gene Symbol

MMP3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacologyInteractions: ENSG00000149968
- Version: 20-July-2020
Alternate Names:

MMP3 GuideToPharmacology Name

P08254 UniProtKB ID

Gene Info:

Publications:
TTD: Matrix metalloproteinase-3
- Version: 2020.06.01
Alternate Names:

MMP-3 TTD Gene Abbreviation

T86702 TTD Target ID

Gene Info:

Publications:
Pharos: MMP3
- Version: 03-September-2020
Alternate Names:

Stromelysin-1 Gene Name

P08254 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: MMP3
- Version: 05-September-2020
Alternate Names:

STMY1 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE, NEUTRAL ZINC METALLOPEPTIDASE

Publications:
dGene: MMP3
- Version: 27-Jun-2013
Alternate Names:

4314 Gene ID

CHDS6 dGene Synonym

MMP-3 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

MMP3	Uniprot Gene Name
MMP3_HUMAN	Uniprot Id
ENSG00000149968	Ensembl Gene Id

matrix metallopeptidase 3 (stromelysin 1, progelatinase)	HUGO Gene Name
7173	HUGO Gene ID
MMP3	Gene Symbol

4314	Entrez Gene Id
ENSG00000149968; ENSG00000263313	Ensembl Gene Id
MMP3	Gene Symbol

STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08254]	Description
MMP3	Display Id
ENSG00000149968	Ensembl Gene Id

MMP3	DrugBank Gene Name
P08254	UniProt Accession
4314	Entrez Gene Id

Trial Name	-
Novel drug target	Novel Target

MMP3 Gene Record

MMP3 4314 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Novel Target

Publications: Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: vaccine (activating)

Interaction Info: Notes

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality: n/a

Interaction Info:

Publications: de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000149968

Alternate Names: MMP3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P08254

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Novel Target

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

vaccine (activating)

Interaction Info:

Notes

Interaction Types & Directionality:

n/a

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality:

n/a

Publications:

de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol

Interaction Types & Directionality:

n/a

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

MMP3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

MMP3 Uniprot Gene Name

MMP3_HUMAN Uniprot Id

ENSG00000149968 Ensembl Gene Id

Gene Info:

Interpro Short Name Peptidase_Metallo

Interpro Type Domain

Interpro Name Peptidase, metallopeptidase

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

matrix metallopeptidase 3 (stromelysin 1, progelatinase) HUGO Gene Name

7173 HUGO Gene ID

MMP3 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name M10: Matrix metallopeptidase

GuideToPharmacology Gene Category ID 738

GuideToPharmacology Gene Type enzyme

Gene Categories:

PROTEASE, NEUTRAL ZINC METALLOPEPTIDASE

Alternate Names:

4314 Entrez Gene Id

ENSG00000149968; ENSG00000263313 Ensembl Gene Id

MMP3 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 3.4.24.17

Alternate Names:

STROMELYSIN-1 PRECURSOR (EC 3.4.24.17) (MATRIX METALLOPROTEINASE-3) (MMP-3) (TRANSIN-1) (SL-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08254] Description

MMP3 Display Id

ENSG00000149968 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MMP3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.24.17

Alternate Names:

PA30886 PharmGKB ID

Publications:

de Maat MP et al., 1999, Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis., Am J Cardiol

Alternate Names:

MMP3 DrugBank Gene Name

P08254 UniProt Accession

4314 Entrez Gene Id

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Publications:

Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod

Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

Alternate Names:

MMP3 Gene Symbol

Alternate Names:

ENSG00000149968 Gene Symbol

MMP3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MMP3 GuideToPharmacology Name

P08254 UniProtKB ID