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MSH6 Gene Record

  • Summary
  • Interactions
  • Claims
  • MSH6 2956 Clinically Actionable

    Alternate Names:

    2956
    MUTS HOMOLOG 6
    MSH6
    GTBP
    GTMBP
    HNPCC5
    HSAP
    p160
    600678
    7329
    ENSG00000116062
    OTTHUMG00000129129
    2478
    MMRCS3

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DNA REPAIR
    CLINICALLY ACTIONABLE

    Publications:

    Yip et al., 2009, MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance., Clin. Cancer Res.
    Cahill et al., 2007, Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment., Clin. Cancer Res.
    Castro et al., 2015, Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations., J Immunother Cancer
  • DURVALUMAB   MSH6

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26674132


    Sources:
    CIViC

  • TEMOZOLOMIDE   MSH6

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type glioblastoma multiforme
    Response Type resistant
    Approval Status Preclinical

    PMIDs:
    19584161 17404084


    Sources:
    JAX-CKB NCI

  • Ensembl: ENSG00000116062

    • Version: 101_38

    Alternate Names:
    MSH6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • JAX-CKB: MSH6

    • Version: 27-September-2017

    Alternate Names:
    2956 CKB Entrez Id
    MSH6 CKB Gene Synonym
    GTBP CKB Gene Synonym

    Gene Info:

    Publications:
    Martin et al., 2011, Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers., Cancer Res.
    Palomaki et al., 2009, EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome., Genet. Med.
    Kastrinos et al., 2016, Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer., J. Natl. Cancer Inst.

  • CIViC: MSH6

    • Version: 14-September-2020

    Alternate Names:
    2956 Entrez Gene ID
    2478 CIViC Gene ID

    Gene Info:

    Publications:
    Castro et al., 2015, Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations., J Immunother Cancer

  • NCI: MSH6

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Cahill et al., 2007, Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment., Clin. Cancer Res.

  • GO: MSH6

    • Version: 01-February-2022

    Alternate Names:
    GTBP GO Gene Synonym

    Gene Info:

    Gene Categories:
    DNA REPAIR

    Publications:

  • Tempus: MSH6

    • Version: 11-November-2018

    Alternate Names:
    MSH6 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • MskImpact: MSH6

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: MSH6

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: MSH6

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: MSH6

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21