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NCOA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NCOA1 8648 Clinically Actionable

    Alternate Names:

    8648
    NUCLEAR RECEPTOR COACTIVATOR 1
    NCOA1
    F-SRC-1
    KAT13A
    RIP160
    SRC1
    bHLHe42
    bHLHe74
    602691
    7668
    ENSG00000084676
    OTTHUMG00000125523
    PA31470
    BE0003728
    Q15788
    2693
    NCoA-1
    NP_003734
    NM_003743

    Gene Info:

    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 2.3.1.48 Histone acetyltransferases (HATs)
    GuideToPharmacology Gene Category ID 872
    (4 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    CLINICALLY ACTIONABLE
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Hartmaier RJ et al., 2012, A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone., Mol Endocrinol
  • CHEMBL187105   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL363498   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • GW590735   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL364092   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL185918   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL192154   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL395308   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL190467   NCOA1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL184151   NCOA1

    Interaction Score: 1.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • PRINABEREL   NCOA1

    Interaction Score: 1.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • ALEGLITAZAR   NCOA1

    Interaction Score: 1.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL486954   NCOA1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • INDEGLITAZAR   NCOA1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CORTICOSTERONE   NCOA1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • T091317   NCOA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • MYRISTIC ACID   NCOA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL533226   NCOA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHYLTHIONINIUM CHLORIDE   NCOA1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   NCOA1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • TAMOXIFEN   NCOA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22174377


    Sources:
    PharmGKB

  • ETOPOSIDE   NCOA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000084676

    • Version: 101_38

    Alternate Names:
    NCOA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • GuideToPharmacology: 8648

    • Version: 29-September-2020

    Alternate Names:
    7668 HUGO Gene ID
    7668 HUGO Gene Symbol
    nuclear receptor coactivator 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 2.3.1.48 Histone acetyltransferases (HATs)
    GuideToPharmacology Gene Category ID 872

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: NCOA1

    • Version: 18-August-2020

    Alternate Names:
    PA31470 PharmGKB ID

    Gene Info:

    Publications:
    Hartmaier RJ et al., 2012, A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone., Mol Endocrinol

  • DrugBank: BE0003728

    • Version: 5.1.7

    Alternate Names:
    NCOA1 DrugBank Gene Name
    Q15788 UniProt Accession
    8648 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • HumanProteinAtlas: NCOA1

    • Version: 19.3

    Alternate Names:
    ENSG00000084676 Ensembl Gene ID
    bHLHe74 Human Protein Atlas Gene Synonym
    F-SRC-1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: NCOA1

    • Version: 03-September-2020

    Alternate Names:
    Nuclear receptor coactivator 1 Gene Name
    Q15788 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

  • DTC: NCOA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • CarisMolecularIntelligence: NCOA1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21