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NFKB2 Gene Record

  • Summary
  • Interactions
  • Claims
  • NFKB2 4791 Druggable GenomeClinically Actionable

    Alternate Names:

    4791
    NUCLEAR FACTOR KAPPA B SUBUNIT 2
    NFKB2
    CVID10
    H2TF1
    LYT-10
    LYT10
    NF-kB2
    p100
    p49/p100
    p52
    164012
    7795
    ENSG00000077150
    OTTHUMG00000018962
    Q00653
    NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653]
    NUCLEAR FACTOR NF-KAPPA-B
    NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
    NFKB2_HUMAN
    NFKB
    T83145

    Gene Info:

    Target Class Transcription factor
    Target Subclass Transcription factor
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name NF_Rel_dor
    Interpro Name NF-kappa-B/Rel/dorsal
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Interpro Acc IPR000451
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
    Okorji UP et al., 2014, A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia., Bioorg Med Chem
    Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem
    Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem
  • LAQUINIMOD   NFKB2

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • EDASALONEXENT   NFKB2

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TRIPTOLIDE   NFKB2

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PARTHENOLIDE   NFKB2

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC TTD

  • CHRYSOERIOL   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • SORBINIL   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24819954


    Sources:
    DTC

  • TAMARIXETIN   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • KAEMPFERIDE   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • DIOSMETIN   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • ISORHAMNETIN   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • QUERCETAGETIN   NFKB2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • ARTESUNATE   NFKB2

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25074847


    Sources:
    DTC

  • CHEMBL1405979   NFKB2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VADIMEZAN   NFKB2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RUTIN   NFKB2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25496805


    Sources:
    DTC

  • GOSSYPETIN   NFKB2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • PECTOLINARIGENIN   NFKB2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FRENTIZOLE   NFKB2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACACETIN   NFKB2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • CHEMBL502774   NFKB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL260560   NFKB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL406557   NFKB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KAEMPFEROL   NFKB2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • 4',7-DIMETHOXY-5-HYDROXYGENISTEIN   NFKB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL85826   NFKB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 6,4'-DIMETHOXYFLAVONE   NFKB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • INDOPROFEN   NFKB2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL201325   NFKB2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL602718   NFKB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL408850   NFKB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2094789   NFKB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   NFKB2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • CHEMBL528694   NFKB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL428789   NFKB2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL84010   NFKB2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LUTEOLIN   NFKB2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • SULFASALAZINE   NFKB2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • QUERCETIN   NFKB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • BORTEZOMIB   NFKB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC TTD

  • RESVERATROL   NFKB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000077150

    • Version: 101_38

    Alternate Names:
    NFKB2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q00653

    • Version: January-2014

    Alternate Names:
    NFKB2 Gene Symbol

    Gene Info:
    Target Class Transcription factor
    Target Subclass Transcription factor

    Publications:

  • RussLampel: ENSG00000077150

    • Version: 26-July-2011

    Alternate Names:
    NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653] Description
    ENSG00000077150 Ensembl Gene Id
    NFKB2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q00653

    • Version: 11-September-2012

    Alternate Names:
    NFKB2_HUMAN Uniprot Id
    NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT Uniprot Protein Name
    4791 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name NF_Rel_dor
    Interpro Name NF-kappa-B/Rel/dorsal

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Nuclear factor NF-kappa-B

    • Version: 2020.06.01

    Alternate Names:
    NFKB TTD Gene Abbreviation
    T83145 TTD Target ID

    Gene Info:

    Publications:
    Shanmugam R et al., 2011, A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species., Int J Cancer

  • DTC: NFKB2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
    Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem
    Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem

  • TALC: NFKB

    • Version: 12-May-2016

    Alternate Names:
    NFKB Gene Symbol

    Gene Info:

    Publications:

  • Pharos: NFKB2

    • Version: 01-February-2022

    Alternate Names:
    Nuclear factor NF-kappa-B p100 subunit Gene Name
    Q00653 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • FoundationOneGenes: NFKB2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: NFKB2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21