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NFKB2 Gene Record

  • Summary
  • Interactions
  • Claims
  • NFKB2 4791 Druggable GenomeClinically Actionable

    Alternate Names:

    4791
    NUCLEAR FACTOR KAPPA B SUBUNIT 2
    NFKB2
    CVID10
    H2TF1
    LYT-10
    LYT10
    NF-kB2
    p100
    p49/p100
    p52
    164012
    7795
    ENSG00000077150
    OTTHUMG00000018962
    BE0002387
    Q00653
    BE0004903
    NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653]
    NUCLEAR FACTOR NF-KAPPA-B
    NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
    NFKB2_HUMAN
    NFKB
    T83145
    BE0009554

    Gene Info:

    Target Class Transcription factor
    Target Subclass Transcription factor
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name NF_Rel_dor
    Interpro Name NF-kappa-B/Rel/dorsal
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Interpro Acc IPR000451
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
    Okorji UP et al., 2014, A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia., Bioorg Med Chem
    Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem
    Largo et al., 2003, Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes., Osteoarthr. Cartil.
    Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem
    Rodríguez-Cruz M et al., 2017, Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors., Nutrition
    Srinivasan M et al., 2015, Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis., Expert Opin Ther Targets
    Kim HG et al., 2014, Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo., Neurotoxicology
    Kim SJ et al., 2005, Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells., J Pharmacol Exp Ther
    Wong BC et al., 2003, Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer., Oncogene
    Li JY et al., 2014, Glycyrrhizic acid in the treatment of liver diseases: literature review., Biomed Res Int
  • CHEMBL282093   NFKB2

    Interaction Score: 3.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15784648 12606945


    Sources:
    DrugBank

  • LAQUINIMOD   NFKB2

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • EDASALONEXENT   NFKB2

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TRIPTOLIDE   NFKB2

    Interaction Score: 1.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PARTHENOLIDE   NFKB2

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC TTD

  • CHRYSOERIOL   NFKB2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • TAMARIXETIN   NFKB2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • KAEMPFERIDE   NFKB2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • DIOSMETIN   NFKB2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • ISORHAMNETIN   NFKB2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • QUERCETAGETIN   NFKB2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • SORBINIL   NFKB2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24819954


    Sources:
    DTC

  • GLUCOSAMINE   NFKB2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    12681956


    Sources:
    DrugBank

  • SGN-30   NFKB2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • HE3286   NFKB2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ARTESUNATE   NFKB2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25074847


    Sources:
    DTC

  • GLYCYRRHIZIN   NFKB2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24963489


    Sources:
    DrugBank

  • CUSTIRSEN   NFKB2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CHEMBL1405979   NFKB2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DONEPEZIL   NFKB2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    25652642 24189446


    Sources:
    DrugBank

  • FISH OIL TRIGLYCERIDES   NFKB2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    28760435


    Sources:
    DrugBank

  • VADIMEZAN   NFKB2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GOSSYPETIN   NFKB2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • RUTIN   NFKB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25496805


    Sources:
    DTC

  • PECTOLINARIGENIN   NFKB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FRENTIZOLE   NFKB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ANDROGRAPHOLIDE   NFKB2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ACACETIN   NFKB2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • CHEMBL502774   NFKB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL260560   NFKB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL406557   NFKB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KAEMPFEROL   NFKB2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • 4',7-DIMETHOXY-5-HYDROXYGENISTEIN   NFKB2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL85826   NFKB2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 6,4'-DIMETHOXYFLAVONE   NFKB2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • INDOPROFEN   NFKB2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL201325   NFKB2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL602718   NFKB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL408850   NFKB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2094789   NFKB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   NFKB2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • CHEMBL528694   NFKB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL428789   NFKB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL84010   NFKB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LUTEOLIN   NFKB2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • SULFASALAZINE   NFKB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BORTEZOMIB   NFKB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TTD TALC

  • QUERCETIN   NFKB2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25190466


    Sources:
    DTC

  • RESVERATROL   NFKB2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000077150

    • Version: 101_38

    Alternate Names:
    NFKB2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q00653

    • Version: January-2014

    Alternate Names:
    NFKB2 Gene Symbol

    Gene Info:
    Target Class Transcription factor
    Target Subclass Transcription factor

    Publications:

  • RussLampel: ENSG00000077150

    • Version: 26-July-2011

    Alternate Names:
    NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653] Description
    ENSG00000077150 Ensembl Gene Id
    NFKB2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q00653

    • Version: 11-September-2012

    Alternate Names:
    NFKB2_HUMAN Uniprot Id
    NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT Uniprot Protein Name
    4791 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name NF_Rel_dor
    Interpro Name NF-kappa-B/Rel/dorsal

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DrugBank: BE0004903

    • Version: 5.1.7

    Alternate Names:
    NFKB2 DrugBank Gene Name
    Q00653 UniProt Accession
    4791 Entrez Gene Id

    Gene Info:

    Publications:
    Srinivasan M et al., 2015, Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis., Expert Opin Ther Targets
    Kim HG et al., 2014, Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo., Neurotoxicology
    Li JY et al., 2014, Glycyrrhizic acid in the treatment of liver diseases: literature review., Biomed Res Int

  • DrugBank: BE0002387

    • Version: 5.1.7

    Alternate Names:
    NFKB2 DrugBank Gene Name
    Q00653 UniProt Accession
    4791 Entrez Gene Id

    Gene Info:

    Publications:
    Largo et al., 2003, Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes., Osteoarthr. Cartil.

  • DrugBank: BE0009554

    • Version: 5.1.7

    Alternate Names:
    NFKB2 DrugBank Gene Name
    Q00653 UniProt Accession
    4791 Entrez Gene Id

    Gene Info:

    Publications:
    Kim SJ et al., 2005, Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells., J Pharmacol Exp Ther
    Wong BC et al., 2003, Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer., Oncogene

  • TTD: Nuclear factor NF-kappa-B

    • Version: 2020.06.01

    Alternate Names:
    NFKB TTD Gene Abbreviation
    T83145 TTD Target ID

    Gene Info:

    Publications:
    Shanmugam R et al., 2011, A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species., Int J Cancer

  • DTC: NFKB2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
    Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem
    Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem

  • TALC: NFKB

    • Version: 12-May-2016

    Alternate Names:
    NFKB Gene Symbol

    Gene Info:

    Publications:

  • Pharos: NFKB2

    • Version: 03-September-2020

    Alternate Names:
    Nuclear factor NF-kappa-B p100 subunit Gene Name
    Q00653 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • FoundationOneGenes: NFKB2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: NFKB2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21