DGIdb - NFKB2 Gene Record

NFKB2 4791 Druggable GenomeClinically Actionable

Alternate Names:

4791
NUCLEAR FACTOR KAPPA B SUBUNIT 2
NFKB2
CVID10
H2TF1
LYT-10
LYT10
NF-kB2
p100
p49/p100
p52
164012
7795
ENSG00000077150
OTTHUMG00000018962
BE0002387
Q00653
BE0004903
NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653]
NUCLEAR FACTOR NF-KAPPA-B
NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT
NFKB2_HUMAN
NFKB
T83145
BE0009554

Gene Info:

Target Class	Transcription factor
Target Subclass	Transcription factor
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	NF_Rel_dor
Interpro Name	NF-kappa-B/Rel/dorsal
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Interpro Acc	IPR000451
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
Okorji UP et al., 2014, A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia., Bioorg Med Chem
Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem
Largo et al., 2003, Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes., Osteoarthr. Cartil.
Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem
Rodríguez-Cruz M et al., 2017, Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors., Nutrition
Srinivasan M et al., 2015, Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis., Expert Opin Ther Targets
Kim HG et al., 2014, Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo., Neurotoxicology
Kim SJ et al., 2005, Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells., J Pharmacol Exp Ther
Wong BC et al., 2003, Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer., Oncogene
Li JY et al., 2014, Glycyrrhizic acid in the treatment of liver diseases: literature review., Biomed Res Int

CHEMBL282093 NFKB2

Interaction Score: 3.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15784648 12606945

Sources:
DrugBank
LAQUINIMOD NFKB2

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
EDASALONEXENT NFKB2

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRIPTOLIDE NFKB2

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PARTHENOLIDE NFKB2

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC TTD
CHRYSOERIOL NFKB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
TAMARIXETIN NFKB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
KAEMPFERIDE NFKB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
DIOSMETIN NFKB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
ISORHAMNETIN NFKB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
QUERCETAGETIN NFKB2

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
SORBINIL NFKB2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24819954

Sources:
DTC
GLUCOSAMINE NFKB2

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
12681956

Sources:
DrugBank
SGN-30 NFKB2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
HE3286 NFKB2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ARTESUNATE NFKB2

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25074847

Sources:
DTC
GLYCYRRHIZIN NFKB2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
24963489

Sources:
DrugBank
CUSTIRSEN NFKB2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CHEMBL1405979 NFKB2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DONEPEZIL NFKB2

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25652642 24189446

Sources:
DrugBank
FISH OIL TRIGLYCERIDES NFKB2

Interaction Score: 0.23

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
28760435

Sources:
DrugBank
VADIMEZAN NFKB2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GOSSYPETIN NFKB2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
RUTIN NFKB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25496805

Sources:
DTC
PECTOLINARIGENIN NFKB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FRENTIZOLE NFKB2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANDROGRAPHOLIDE NFKB2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ACACETIN NFKB2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
CHEMBL502774 NFKB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL260560 NFKB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL406557 NFKB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KAEMPFEROL NFKB2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
4',7-DIMETHOXY-5-HYDROXYGENISTEIN NFKB2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL85826 NFKB2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
6,4'-DIMETHOXYFLAVONE NFKB2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INDOPROFEN NFKB2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL201325 NFKB2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL602718 NFKB2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL408850 NFKB2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2094789 NFKB2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APIGENIN NFKB2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
CHEMBL528694 NFKB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL428789 NFKB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL84010 NFKB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LUTEOLIN NFKB2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
SULFASALAZINE NFKB2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BORTEZOMIB NFKB2

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TTD TALC
QUERCETIN NFKB2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
RESVERATROL NFKB2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000077150
- Version: 101_38
Alternate Names:

NFKB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q00653
- Version: January-2014
Alternate Names:

NFKB2 Gene Symbol

Gene Info:

Target Class Transcription factor

Target Subclass Transcription factor

Publications:

RussLampel: ENSG00000077150

Version: 26-July-2011

Alternate Names:

NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653] Description

ENSG00000077150 Ensembl Gene Id

NFKB2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q00653
- Version: 11-September-2012
Alternate Names:

NFKB2_HUMAN Uniprot Id

NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT Uniprot Protein Name

4791 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name NF_Rel_dor

Interpro Name NF-kappa-B/Rel/dorsal

Gene Categories:

DRUGGABLE GENOME

Publications:

DrugBank: BE0004903

Version: 5.1.7

Alternate Names:

NFKB2 DrugBank Gene Name

Q00653 UniProt Accession

4791 Entrez Gene Id

Gene Info:

Publications:

Srinivasan M et al., 2015, Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis., Expert Opin Ther Targets

Kim HG et al., 2014, Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo., Neurotoxicology

Li JY et al., 2014, Glycyrrhizic acid in the treatment of liver diseases: literature review., Biomed Res Int

DrugBank: BE0002387
- Version: 5.1.7
Alternate Names:

NFKB2 DrugBank Gene Name

Q00653 UniProt Accession

4791 Entrez Gene Id

Gene Info:

Publications:

Largo et al., 2003, Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes., Osteoarthr. Cartil.

DrugBank: BE0009554

Version: 5.1.7

Alternate Names:

NFKB2 DrugBank Gene Name

Q00653 UniProt Accession

4791 Entrez Gene Id

Gene Info:

Publications:

Kim SJ et al., 2005, Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells., J Pharmacol Exp Ther

Wong BC et al., 2003, Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer., Oncogene

TTD: Nuclear factor NF-kappa-B

Version: 2020.06.01

Alternate Names:

NFKB TTD Gene Abbreviation

T83145 TTD Target ID

Gene Info:

Publications:

Shanmugam R et al., 2011, A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species., Int J Cancer

DTC: NFKB2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett

Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem

Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem

TALC: NFKB
- Version: 12-May-2016
Alternate Names:

NFKB Gene Symbol

Gene Info:

Publications:
Pharos: NFKB2
- Version: 03-September-2020
Alternate Names:

Nuclear factor NF-kappa-B p100 subunit Gene Name

Q00653 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
FoundationOneGenes: NFKB2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: NFKB2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

NUCLEAR FACTOR NF-KAPPA-B P100/P49 SUBUNITS (DNA-BINDING FACTOR KBF2) (H2TF1) (LYMPHOCYTE TRANSLOCATION CHROMOSOME 10) (ONCOGENE LYT-10) (LYT10) [CONTAINS: NUCLEAR FACTOR NF-KAPPA-B P52 SUBUNIT]. [SOURCE:UNIPROT/SWISSPROT;ACC:Q00653]	Description
ENSG00000077150	Ensembl Gene Id
NFKB2	Display Id

NFKB2_HUMAN	Uniprot Id
NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT	Uniprot Protein Name
4791	Entrez Gene Id

NFKB2	DrugBank Gene Name
Q00653	UniProt Accession
4791	Entrez Gene Id

Nuclear factor NF-kappa-B p100 subunit	Gene Name
Q00653	UniProt ID

NFKB2 Gene Record

NFKB2 4791 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15784648 12606945

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24819954

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 12681956

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25074847

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 24963489

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15784648 12606945

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC TTD

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24819954

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
12681956

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
25074847

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
24963489

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25652642 24189446

Sources:
DrugBank

Interaction Types & Directionality:

modulator

PMIDs:
28760435

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25496805

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found