• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NFKBIA Gene Record

  • Summary
  • Interactions
  • Claims
  • NFKBIA 4792 Druggable GenomeClinically Actionable

    Alternate Names:

    4792
    NFKB INHIBITOR ALPHA
    NFKBIA
    IKBA
    MAD-3
    NFKBI
    164008
    7797
    ENSG00000100906
    OTTHUMG00000140220
    PA31601
    EDAID2
    MAD3

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Folmer F et al., 2008, NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus., J Nat Prod
    Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
    Sun H et al., 2012, Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ)., Eur J Med Chem
    Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J
    Tamura R et al., 2012, Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines., Bioorg Med Chem Lett
    Wang L et al., 2013, Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition., J Nat Prod
    Tsutsui C et al., 2009, Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway., Bioorg Med Chem Lett
  • PEPEROMIN E   NFKBIA

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19559609


    Sources:
    DTC

  • DIOSCIN   NFKBIA

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23621869


    Sources:
    DTC

  • CHEMBL1940084   NFKBIA

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22153345


    Sources:
    DTC

  • CHEMBL256967   NFKBIA

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18088098


    Sources:
    DTC

  • CHEMBL401565   NFKBIA

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18088098


    Sources:
    DTC

  • DEMETHYLWEDELOLACTONE   NFKBIA

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926226


    Sources:
    DTC

  • GAMBOGIC ACID   NFKBIA

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22472167


    Sources:
    DTC

  • WEDELOLACTONE   NFKBIA

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926226


    Sources:
    DTC

  • GEFITINIB   NFKBIA

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31664190


    Sources:
    PharmGKB

  • Ensembl: ENSG00000100906

    • Version: 101_38

    Alternate Names:
    NFKBIA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: NFKBIA

    • Version: 18-August-2020

    Alternate Names:
    PA31601 PharmGKB ID

    Gene Info:

    Publications:
    Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

  • DTC: NFKBIA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Tamura R et al., 2012, Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines., Bioorg Med Chem Lett
    Folmer F et al., 2008, NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus., J Nat Prod
    Wang L et al., 2013, Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition., J Nat Prod

  • HingoraniCasas: ENSG00000100906

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100906 Gene Symbol
    NFKBIA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: NFKBIA

    • Version: 01-February-2022

    Alternate Names:
    IKBA GO Gene Synonym
    MAD3 GO Gene Synonym
    NFKBI GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING

    Publications:

  • Tempus: NFKBIA

    • Version: 11-November-2018

    Alternate Names:
    NFKBIA Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: NFKBIA

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: NFKBIA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21