DGIdb - NFKBIA Gene Record

NFKBIA 4792 Druggable GenomeClinically Actionable

Alternate Names:

4792
NFKB INHIBITOR ALPHA
NFKBIA
IKBA
MAD-3
NFKBI
164008
7797
ENSG00000100906
OTTHUMG00000140220
PA31601
EDAID2
MAD3

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Folmer F et al., 2008, NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus., J Nat Prod
Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
Sun H et al., 2012, Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ)., Eur J Med Chem
Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J
Tamura R et al., 2012, Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines., Bioorg Med Chem Lett
Wang L et al., 2013, Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition., J Nat Prod
Tsutsui C et al., 2009, Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway., Bioorg Med Chem Lett

PEPEROMIN E NFKBIA

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19559609

Sources:
DTC
DIOSCIN NFKBIA

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23621869

Sources:
DTC
CHEMBL1940084 NFKBIA

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22153345

Sources:
DTC
CHEMBL256967 NFKBIA

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18088098

Sources:
DTC
CHEMBL401565 NFKBIA

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18088098

Sources:
DTC
DEMETHYLWEDELOLACTONE NFKBIA

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926226

Sources:
DTC
GAMBOGIC ACID NFKBIA

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22472167

Sources:
DTC
WEDELOLACTONE NFKBIA

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22926226

Sources:
DTC
GEFITINIB NFKBIA

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31664190

Sources:
PharmGKB

Ensembl: ENSG00000100906
- Version: 101_38
Alternate Names:

NFKBIA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: NFKBIA
- Version: 18-August-2020
Alternate Names:

PA31601 PharmGKB ID

Gene Info:

Publications:

Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

DTC: NFKBIA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tamura R et al., 2012, Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines., Bioorg Med Chem Lett

Folmer F et al., 2008, NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus., J Nat Prod

Wang L et al., 2013, Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition., J Nat Prod

HingoraniCasas: ENSG00000100906
- Version: 31-May-2017
Alternate Names:

ENSG00000100906 Gene Symbol

NFKBIA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: NFKBIA
- Version: 01-February-2022
Alternate Names:

IKBA GO Gene Synonym

MAD3 GO Gene Synonym

NFKBI GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Publications:
Tempus: NFKBIA
- Version: 11-November-2018
Alternate Names:

NFKBIA Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: NFKBIA
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: NFKBIA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

NFKBIA Gene Record

NFKBIA 4792 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19559609

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23621869

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22153345

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18088098

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18088098

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22926226

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22472167

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22926226

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31664190

Sources: PharmGKB

Ensembl: ENSG00000100906

Alternate Names: NFKBIA Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: NFKBIA

Alternate Names: PA31601 PharmGKB ID

Gene Info:

Publications: Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

DTC: NFKBIA

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000100906

Alternate Names: ENSG00000100906 Gene Symbol NFKBIA Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: NFKBIA

Alternate Names: IKBA GO Gene Synonym MAD3 GO Gene Synonym NFKBI GO Gene Synonym

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR BINDING

Publications:

Tempus: NFKBIA

Alternate Names: NFKBIA Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: NFKBIA

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: NFKBIA

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
19559609

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23621869

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22153345

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18088098

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18088098

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22926226

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22472167

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22926226

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
31664190

Sources:
PharmGKB

Alternate Names:

NFKBIA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA31601 PharmGKB ID

Publications:

Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

Alternate Names:

ENSG00000100906 Gene Symbol

NFKBIA Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IKBA GO Gene Synonym

MAD3 GO Gene Synonym

NFKBI GO Gene Synonym

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Alternate Names:

NFKBIA Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE