• Interaction Score: 11.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive
    Approval Status Phase I

    PMIDs:
    23774673


    Sources:
    JAX-CKB TTD

  • Interaction Score: 5.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Approval Status Preclinical - Cell culture
    Indication/Tumor Type triple-receptor negative breast cancer
    Response Type sensitive

  • Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type head and neck squamous cell carcinoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    24277854


    Sources:
    JAX-CKB

  • Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type lung cancer
    Indication/Tumor Type breast cancer
    Indication/Tumor Type glioblastoma multiforme

    PMIDs:
    None found


    Sources:
    JAX-CKB TTD

  • Interaction Score: 2.5

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    combination therapy Radiotherapy + RO4929097 + Temozolomide
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive

  • Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Asparaginase
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type decreased response

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Everolimus
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Radiotherapy + RO4929097 + Temozolomide
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive

    PMIDs:
    27154916


    Sources:
    JAX-CKB

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Prednisolone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Mercaptopurine
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type decreased response

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11948681


    Sources:
    NCI

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Everolimus
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy PF-03084014 + Docetaxel
    Indication/Tumor Type prostate cancer
    Response Type predicted – sensitive

    PMIDs:
    26202948


    Sources:
    JAX-CKB

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Dexamethasone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy MRK-003 + Paclitaxel
    Indication/Tumor Type triple-receptor negative breast cancer
    Response Type no benefit

    PMIDs:
    25104330


    Sources:
    JAX-CKB

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Methotrexate
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type decreased response

    PMIDs:
    28151717


    Sources:
    JAX-CKB