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NR1H4 Gene Record

  • Summary
  • Interactions
  • Claims
  • NR1H4 9971 Druggable Genome

    Alternate Names:

    9971
    NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 4
    NR1H4
    BAR
    FXR
    HRR-1
    HRR1
    PFIC5
    RIP14
    603826
    7967
    ENSG00000012504
    OTTHUMG00000170359
    RETINOID X RECEPTOR-INTERACTING PROTEIN 14
    RXR-INTERACTING PROTEIN 14
    BILE ACID RECEPTOR
    FARNESOL RECEPTOR HRR-1
    Q96RI1
    FARNESOID X-ACTIVATED RECEPTOR
    NR1H4_HUMAN
    BILE ACID RECEPTOR (FARNESOID X-ACTIVATED RECEPTOR) (FARNESOL RECEPTOR HRR-1) (RETINOID X RECEPTOR-INTERACTING PROTEIN 14) (RXR-INTERACTING PROTEIN 14). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RI1]
    T51426

    Gene Info:

    Initial Gene Query NR1H4
    Counted Citations from 1950-2000 792
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Target Class Receptors
    Target Subclass Nuclear receptor
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    KINASE
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Nam SJ et al., 2007, Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity., J Nat Prod
    Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem
    Grienke U et al., 2011, Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum., Bioorg Med Chem
    Choi H et al., 2011, Tuberatolides, potent FXR antagonists from the Korean marine tunicate Botryllus tuberatus., J Nat Prod
    Lin HR et al., 2014, Cryptochinones from Cryptocarya chinensis act as farnesoid X receptor agonists., Bioorg Med Chem Lett
    De Marino S et al., 2011, Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors., J Med Chem
    Di Leva FS et al., 2013, Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands., J Med Chem
    D'Amore C et al., 2014, Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors., J Med Chem
    Gioiello A et al., 2011, Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine., Bioorg Med Chem
    Festa C et al., 2014, Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands., J Med Chem
    Bass JY et al., 2011, Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene., Bioorg Med Chem Lett
    Schuster D et al., 2011, Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation., Bioorg Med Chem
    Sepe V et al., 2014, Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)., J Med Chem
    Sepe V et al., 2012, Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei., J Med Chem
    Sepe V et al., 2011, Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor., J Med Chem
    Yu DD et al., 2013, Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery., Bioorg Med Chem
  • OBETICHOLIC ACID   NR1H4

    Interaction Score: 4.76

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Bile acid receptor FXR agonist

    PMIDs:
    24387325 21459580 25247751


    Sources:
    DTC ChemblInteractions

  • GANODERMANONTRIOL   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014750


    Sources:
    DTC

  • YEZOQUINOLIDE   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21142112


    Sources:
    DTC

  • CRYPTOCHINONE B   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25127166


    Sources:
    DTC

  • LUCIDUMOL A   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014750


    Sources:
    DTC

  • CHEMBL476302   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21256005


    Sources:
    DTC

  • ERGOSTEROL PEROXIDE   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014750


    Sources:
    DTC

  • GANODERIC ACID TR   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014750


    Sources:
    DTC

  • TUBERATOLIDE B   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21142112


    Sources:
    DTC

  • 7-O-METHYLCRYPTOCHINONE B   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25127166


    Sources:
    DTC

  • CRYPTOCHINONE A   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25127166


    Sources:
    DTC

  • TUBERATOLIDE A   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21142112


    Sources:
    DTC

  • (S)-SARGACHROMENOL   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21142112


    Sources:
    DTC

  • 7-O-METHYLCRYPTOCHINONE A   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25127166


    Sources:
    DTC

  • 2'-EPI-TUBERATOLIDE B   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21142112


    Sources:
    DTC

  • (R)-SARGACHROMENOL   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21142112


    Sources:
    DTC

  • GANODERIOL F   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014750


    Sources:
    DTC

  • CHEMBL269105   NR1H4

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17988093


    Sources:
    DTC

  • CHENODIOL   NR1H4

    Interaction Score: 1.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Bile acid receptor FXR agonist
    Direct Interaction yes

    PMIDs:
    21459580 17963371 22018919 25162837 22014750 22126372 21309576 25247751 24387325


    Sources:
    DTC ChemblInteractions TTD

  • CONICASTEROL D   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • TUROFEXORATE ISOPROPYL   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Bile acid receptor FXR agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CONICASTEROL E   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22126372


    Sources:
    DTC

  • THEONELLASTEROL B   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • THEONELLASTEROL E   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • PX-102   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Bile acid receptor FXR agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEONELLASTEROL G   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • CONICASTEROL B   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • SUVANINE'S SODIUM SALT   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23656455


    Sources:
    DTC

  • THEONELLASTEROL C   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • TROPIFEXOR   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THEONELLASTEROL F   NR1H4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • FLUSILAZOLE   NR1H4

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • URSODIOL   NR1H4

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Bile acid receptor FXR agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDRAMETHYLNON   NR1H4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUOXASTROBIN   NR1H4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIBUTYLCHLOROSTANNANE   NR1H4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUAZINAM   NR1H4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIFENOCONAZOLE   NR1H4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GUGGULSTERONE   NR1H4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LITHOCHOLIC ACID   NR1H4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17963371


    Sources:
    DTC

  • IMIPRAMINE HYDROCHLORIDE   NR1H4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SAQUINAVIR MESYLATE   NR1H4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIMODIPINE   NR1H4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23688559


    Sources:
    DTC

  • PHENOLPHTHALEIN   NR1H4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 3R14S-OCHRATOXIN A   NR1H4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHYLENE BLUE   NR1H4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BENZO(K)FLUORANTHENE   NR1H4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • T091317   NR1H4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PENTABROMOPHENOL   NR1H4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZEARALENONE   NR1H4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL184450   NR1H4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PENTACHLOROPHENOL   NR1H4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL297304   NR1H4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENAZOPYRIDINE HYDROCHLORIDE   NR1H4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICHLOROPHEN   NR1H4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLIOQUINOL   NR1H4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MELPHALAN   NR1H4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   NR1H4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RALOXIFENE HYDROCHLORIDE   NR1H4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIMEROSAL   NR1H4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   NR1H4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIETHYLSTILBESTROL   NR1H4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HOMIDIUM BROMIDE   NR1H4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN HYDROCHLORIDE   NR1H4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENISTEIN   NR1H4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000012504

    • Version: 101_38

    Alternate Names:
    NR1H4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: NR1H4

    • Version: February-2014

    Alternate Names:
    9971 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1H4
    Counted Citations from 1950-2000 792

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TdgClinicalTrial: Q96RI1

    • Version: January-2014

    Alternate Names:
    NR1H4 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • RussLampel: ENSG00000012504

    • Version: 26-July-2011

    Alternate Names:
    NR1H4 Display Id
    BILE ACID RECEPTOR (FARNESOID X-ACTIVATED RECEPTOR) (FARNESOL RECEPTOR HRR-1) (RETINOID X RECEPTOR-INTERACTING PROTEIN 14) (RXR-INTERACTING PROTEIN 14). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RI1] Description
    ENSG00000012504 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q96RI1

    • Version: 11-September-2012

    Alternate Names:
    NR1H4_HUMAN Uniprot Id
    9971 Entrez Gene Id
    ENSG00000012504 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • DTC: NR1H4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Nam SJ et al., 2007, Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity., J Nat Prod
    Lin HR et al., 2014, Cryptochinones from Cryptocarya chinensis act as farnesoid X receptor agonists., Bioorg Med Chem Lett
    Grienke U et al., 2011, Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum., Bioorg Med Chem

  • HingoraniCasas: ENSG00000012504

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000012504 Gene Symbol
    NR1H4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: BAR

    • Version: chembl_23

    Alternate Names:
    FXR GENE_SYMBOL
    HRR1 GENE_SYMBOL
    RIP14 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: NR1H4

    • Version: 01-February-2022

    Alternate Names:
    BAR GO Gene Synonym
    FXR GO Gene Synonym
    HRR1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: NR1H4

    • Version: 27-Jun-2013

    Alternate Names:
    9971 Gene ID
    BAR dGene Synonym
    FXR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Farnesoid X-activated receptor

    • Version: 2020.06.01

    Alternate Names:
    FXR TTD Gene Abbreviation
    T51426 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: NR1H4

    • Version: 01-February-2022

    Alternate Names:
    Bile acid receptor Gene Name
    Q96RI1 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21