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NR1I2 Gene Record

  • Summary
  • Interactions
  • Claims
  • NR1I2 8856 Druggable Genome

    Alternate Names:

    8856
    NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2
    NR1I2
    BXR
    ONR1
    PAR
    PAR1
    PAR2
    PARq
    PRR
    PXR
    SAR
    SXR
    603065
    7968
    ENSG00000144852
    OTTHUMG00000159400
    ORPHAN NUCLEAR RECEPTOR PXR (PREGNANE X RECEPTOR) (ORPHAN NUCLEAR RECEPTOR PAR1) (STEROID AND XENOBIOTIC RECEPTOR) (SXR). [SOURCE:UNIPROT/SWISSPROT;ACC:O75469]
    O75469
    NR1I2_HUMAN
    PA378

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Initial Gene Query NR1I2
    Counted Citations from 1950-2000 1454
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000536
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Hodnik Ž et al., 2015, Diethylstilbestrol-scaffold-based pregnane X receptor modulators., Eur J Med Chem
    Kretschmer XC et al., 2005, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact
    Festa C et al., 2011, Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity., J Med Chem
    Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol
    Ikezoe et al., 2004, HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo., Cancer Res.
    Lamba J et al., 2008, Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression., Drug Metab Dispos
    Cheng et al., 2009, Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity., Drug Metab. Dispos.
    Chen et al., 2006, Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor., Ann. Clin. Microbiol. Antimicrob.
    Suhara Y et al., 2011, Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists., J Med Chem
    Karthikeyan C et al., 2015, IND-2, a pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells., Bioorg Med Chem
    De Marino S et al., 2011, Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors., J Med Chem
    Sun D et al., 2014, Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development., J Med Chem
    Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem
    Krasowski MD et al., 2011, The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species., BMC Biochem
    Poon PY et al., 2012, Cytoprotective effect of 20S-Rg3 on benzo[a]pyrene-induced DNA damage., Drug Metab Dispos
    Kobayashi K et al., 2004, Key structural features of ligands for activation of human pregnane X receptor., Drug Metab Dispos
    Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.
    Sepe V et al., 2012, Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei., J Med Chem
    Sepe V et al., 2014, Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges., Eur J Med Chem
    Hodnik Ž et al., 2014, Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists., J Med Chem
    Ma et al., 2007, Rifaximin is a gut-specific human pregnane X receptor activator., J. Pharmacol. Exp. Ther.
    Cheng et al., 2010, Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation., J. Pharmacol. Exp. Ther.
    Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos
    Puranik YG et al., 2013, Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy., Pharmacogenomics
    Thorn CF et al., 2011, PharmGKB summary: carbamazepine pathway., Pharmacogenet Genomics
    Du QQ et al., 2013, PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers., Eur J Clin Pharmacol
    Harmsen et al., 2009, Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor., Cancer Chemother. Pharmacol.
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
    Kojima H et al., 2011, Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays., Toxicology
    Mbatchi LC et al., 2017, Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer., Cancer Chemother Pharmacol
    Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol
    Suhara Y et al., 2011, Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K., J Med Chem
    Vandenberghe F et al., 2015, Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort., Clin Pharmacokinet
    Choong E et al., 2013, Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects., J Clin Psychopharmacol
    Stifft F et al., 2018, Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients., Nephrol Dial Transplant
    Kurzawski M et al., 2017, Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients., Pharmacogenet Genomics
    Choi Y et al., 2017, A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET<sup>TM</sup> Plus platform., Pharmacogenomics J
    Bruckmueller H et al., 2015, Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus., Ther Drug Monit
    De Mattia E et al., 2016, Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine., Pharmacogenomics
    Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
    Castillo-Mancilla JR et al., 2016, Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342)., J Antimicrob Chemother
    Bonora S et al., 2015, Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study)., J Antimicrob Chemother
    Schipani A et al., 2010, Population pharmacokinetic modeling of the association between 63396C-&gt;T pregnane X receptor polymorphism and unboosted atazanavir clearance., Antimicrob Agents Chemother
    Siccardi M et al., 2008, Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C--&gt;T) with reduced concentrations of unboosted atazanavir., Clin Infect Dis
    Andrews E et al., 2010, A role for the pregnane X receptor in flucloxacillin-induced liver injury., Hepatology
    Mbatchi LC et al., 2016, Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients., Clin Pharmacokinet
    Noetzli M et al., 2013, Population pharmacokinetic study of memantine: effects of clinical and genetic factors., Clin Pharmacokinet
    Ferraresso M et al., 2013, Long-term effects of ABCB1 and SXR SNPs on the systemic exposure to cyclosporine in pediatric kidney transplant patients., Pharmacogenomics
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Di Leva FS et al., 2013, Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands., J Med Chem
    Narjoz C et al., 2015, Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients., Invest New Drugs
  • RIFAXIMIN   NR1I2

    Interaction Score: 3.9

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21141967 22126372 24388834 24828006 17442842 20627999


    Sources:
    DTC

  • SOLOMONSTEROL A   NR1I2

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21141967 24828006


    Sources:
    DTC

  • MENATETRENONE   NR1I2

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21618996 21561094


    Sources:
    DTC

  • THEONELLASTEROL H   NR1I2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • OXICONAZOLE   NR1I2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    17998298


    Sources:
    PharmGKB

  • THEONELLASTEROL D   NR1I2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • ECONAZOLE   NR1I2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    17998298


    Sources:
    PharmGKB

  • SOLOMONSTEROL B   NR1I2

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21141967


    Sources:
    DTC

  • THEONELLASTEROL G   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • SUVANINE'S SODIUM SALT   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23656455


    Sources:
    DTC

  • CONICASTEROL D   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • THEONELLASTEROL F   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • RIFABUTIN   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CONICASTEROL B   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • NAFCILLIN   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • THEONELLASTEROL B   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • CONICASTEROL E   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22126372


    Sources:
    DTC

  • THEONELLASTEROL C   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • AMG-232   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24456472


    Sources:
    DTC

  • THEONELLASTEROL E   NR1I2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21428459


    Sources:
    DTC

  • CHEMBL398412   NR1I2

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21956953


    Sources:
    DTC

  • ATAZANAVIR   NR1I2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26892777 26174719 20921307 18831695


    Sources:
    PharmGKB

  • TROLEANDOMYCIN   NR1I2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    15039302


    Sources:
    PharmGKB

  • DEMECLOCYCLINE   NR1I2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHEMBL535714   NR1I2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERMETHRIN   NR1I2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21115097


    Sources:
    PharmGKB

  • SULFAMETHAZINE   NR1I2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RIFAPENTINE   NR1I2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MEMANTINE   NR1I2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23371894


    Sources:
    PharmGKB

  • RIFAMPIN   NR1I2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17925385 19460945 16480505 21561094 25537531


    Sources:
    DTC PharmGKB

  • CEFADROXIL   NR1I2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CLINDAMYCIN   NR1I2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TERBINAFINE   NR1I2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METYRAPONE   NR1I2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLOXACILLIN   NR1I2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20222094


    Sources:
    PharmGKB

  • CHENODIOL   NR1I2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17963371


    Sources:
    DTC

  • SULFISOXAZOLE   NR1I2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CEFUROXIME   NR1I2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GRISEOFULVIN   NR1I2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CEPHRADINE   NR1I2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BOSENTAN   NR1I2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DICLOXACILLIN   NR1I2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IFOSFAMIDE   NR1I2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18839173


    Sources:
    PharmGKB

  • CEPHALEXIN   NR1I2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LITHOCHOLIC ACID   NR1I2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17963371


    Sources:
    DTC

  • DOLUTEGRAVIR   NR1I2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MICONAZOLE   NR1I2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    17998298


    Sources:
    PharmGKB

  • SULFINPYRAZONE   NR1I2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    14977870


    Sources:
    PharmGKB

  • CLOTRIMAZOLE   NR1I2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    activator (activating)
    agonist (activating)

    Interaction Info:

    PMIDs:
    14977870 20869355 15849716 17998298


    Sources:
    PharmGKB

  • RITONAVIR   NR1I2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    14977870 15849716


    Sources:
    PharmGKB

  • TACROLIMUS   NR1I2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29733390 28777242 26882121 25271728


    Sources:
    PharmGKB

  • CYPROTERONE   NR1I2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ISRADIPINE   NR1I2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ARTEMISININ   NR1I2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIETHYLSTILBESTROL   NR1I2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26408814 16054614


    Sources:
    DTC PharmGKB

  • TEMSIROLIMUS   NR1I2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28676933


    Sources:
    PharmGKB

  • REPAGLINIDE   NR1I2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23807564


    Sources:
    PharmGKB

  • MINOCYCLINE   NR1I2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SAQUINAVIR   NR1I2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COLFORSIN   NR1I2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BEXAROTENE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUTAMIDE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18839173


    Sources:
    PharmGKB

  • SPIRONOLACTONE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16054614


    Sources:
    PharmGKB

  • MODAFINIL   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BUDESONIDE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMPICILLIN   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CARBAMAZEPINE   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    23252947 21738081 14977870


    Sources:
    PharmGKB

  • DOXYCYCLINE   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PHENYLBUTAZONE   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PHENOBARBITAL   NR1I2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    activator (activating)
    agonist (activating)

    Interaction Info:

    PMIDs:
    15039302 14977870


    Sources:
    PharmGKB

  • ISONIAZID   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PHENYTOIN   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14977870 15039302


    Sources:
    PharmGKB

  • NICARDIPINE   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CEFACLOR   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • GLYBURIDE   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PIOGLITAZONE   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TETRACYCLINE   NR1I2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMOXICILLIN   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IRINOTECAN   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27561454 27116457


    Sources:
    PharmGKB

  • RISPERIDONE   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26129906 23609392


    Sources:
    PharmGKB

  • METFORMIN   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22722338


    Sources:
    PharmGKB

  • ERYTHROMYCIN   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TAMOXIFEN   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16054614 18839173


    Sources:
    PharmGKB

  • SUNITINIB   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25344452


    Sources:
    PharmGKB

  • CHLORPROMAZINE   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EFAVIRENZ   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUVASTATIN   NR1I2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NEVIRAPINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ROSIGLITAZONE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RESERPINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NIFEDIPINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21291553


    Sources:
    PharmGKB

  • TROGLITAZONE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LANSOPRAZOLE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    24193570 15492266


    Sources:
    PharmGKB

  • METHADONE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SIROLIMUS   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28676933


    Sources:
    PharmGKB

  • VINBLASTINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CYCLOSPORINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24088131


    Sources:
    PharmGKB

  • PACLITAXEL   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)
    inducer (activating)

    Interaction Info:

    PMIDs:
    18839173 21151855


    Sources:
    PharmGKB

  • OMEPRAZOLE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCORTISONE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18839173


    Sources:
    PharmGKB

  • TOPIRAMATE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DEXAMETHASONE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16054614


    Sources:
    PharmGKB

  • LOVASTATIN   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27561454


    Sources:
    PharmGKB

  • SIMVASTATIN   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • VINCRISTINE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ATORVASTATIN   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROGESTERONE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CISPLATIN   NR1I2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000144852

    • Version: 101_38

    Alternate Names:
    NR1I2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000144852

    • Version: 26-July-2011

    Alternate Names:
    ORPHAN NUCLEAR RECEPTOR PXR (PREGNANE X RECEPTOR) (ORPHAN NUCLEAR RECEPTOR PAR1) (STEROID AND XENOBIOTIC RECEPTOR) (SXR). [SOURCE:UNIPROT/SWISSPROT;ACC:O75469] Description
    ENSG00000144852 Ensembl Gene Id
    NR1I2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: NR1I2

    • Version: February-2014

    Alternate Names:
    8856 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1I2
    Counted Citations from 1950-2000 1454

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: O75469

    • Version: 11-September-2012

    Alternate Names:
    8856 Entrez Gene Id
    ENSG00000144852 Ensembl Gene Id
    NR1I2_HUMAN Uniprot Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Name Nuclear hormone receptor, ligand-binding, core

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: NR1I2

    • Version: 18-August-2020

    Alternate Names:
    PA378 PharmGKB ID

    Gene Info:

    Publications:
    Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol
    Castillo-Mancilla JR et al., 2016, Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342)., J Antimicrob Chemother
    Bonora S et al., 2015, Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study)., J Antimicrob Chemother

  • DTC: NR1I2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Festa C et al., 2011, Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity., J Med Chem
    De Marino S et al., 2011, Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors., J Med Chem
    Sun D et al., 2014, Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development., J Med Chem

  • HingoraniCasas: ENSG00000144852

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000144852 Gene Symbol
    NR1I2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: NR1I2

    • Version: 01-February-2022

    Alternate Names:
    PXR GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: NR1I2

    • Version: 27-Jun-2013

    Alternate Names:
    8856 Gene ID
    BXR dGene Synonym
    ONR1 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: NR1I2

    • Version: 01-February-2022

    Alternate Names:
    Nuclear receptor subfamily 1 group I member 2 Gene Name
    O75469 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21