DGIdb - NR1I2 Gene Record

NR1I2 8856 Druggable Genome

Alternate Names:

8856
NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2
NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
603065
7968
ENSG00000144852
OTTHUMG00000159400
ORPHAN NUCLEAR RECEPTOR PXR (PREGNANE X RECEPTOR) (ORPHAN NUCLEAR RECEPTOR PAR1) (STEROID AND XENOBIOTIC RECEPTOR) (SXR). [SOURCE:UNIPROT/SWISSPROT;ACC:O75469]
O75469
NR1I2_HUMAN
PA378
606
NP_071285\|NP_003880\|NP_148934
Pregnane X receptor
NM_033013\|NM_003889\|NM_022002

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	NUCLEAR HORMONE RECEPTOR
GuideToPharmacology Gene Category Name	1I. Vitamin D receptor-like receptors
GuideToPharmacology Gene Category ID	90
Initial Gene Query	NR1I2
Counted Citations from 1950-2000	1454
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000536
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Hodnik Ž et al., 2015, Diethylstilbestrol-scaffold-based pregnane X receptor modulators., Eur J Med Chem
Kretschmer XC et al., 2005, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact
Festa C et al., 2011, Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity., J Med Chem
Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol
Ikezoe et al., 2004, HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo., Cancer Res.
Lamba J et al., 2008, Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression., Drug Metab Dispos
Cheng et al., 2009, Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity., Drug Metab. Dispos.
Chen et al., 2006, Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor., Ann. Clin. Microbiol. Antimicrob.
Suhara Y et al., 2011, Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists., J Med Chem
Karthikeyan C et al., 2015, IND-2, a pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells., Bioorg Med Chem
De Marino S et al., 2011, Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors., J Med Chem
Sun D et al., 2014, Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development., J Med Chem
Katona BW et al., 2007, Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids., J Med Chem
Krasowski MD et al., 2011, The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species., BMC Biochem
Poon PY et al., 2012, Cytoprotective effect of 20S-Rg3 on benzo[a]pyrene-induced DNA damage., Drug Metab Dispos
Kobayashi K et al., 2004, Key structural features of ligands for activation of human pregnane X receptor., Drug Metab Dispos
Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.
Sepe V et al., 2012, Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei., J Med Chem
Sepe V et al., 2014, Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges., Eur J Med Chem
Hodnik Ž et al., 2014, Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists., J Med Chem
Ma et al., 2007, Rifaximin is a gut-specific human pregnane X receptor activator., J. Pharmacol. Exp. Ther.
Cheng et al., 2010, Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation., J. Pharmacol. Exp. Ther.
Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos
Puranik YG et al., 2013, Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy., Pharmacogenomics
Thorn CF et al., 2011, PharmGKB summary: carbamazepine pathway., Pharmacogenet Genomics
Du QQ et al., 2013, PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers., Eur J Clin Pharmacol
Harmsen et al., 2009, Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor., Cancer Chemother. Pharmacol.
Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
Kojima H et al., 2011, Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays., Toxicology
Mbatchi LC et al., 2017, Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer., Cancer Chemother Pharmacol
Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol
Suhara Y et al., 2011, Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K., J Med Chem
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Vandenberghe F et al., 2015, Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort., Clin Pharmacokinet
Choong E et al., 2013, Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects., J Clin Psychopharmacol
Stifft F et al., 2018, Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients., Nephrol Dial Transplant
Kurzawski M et al., 2017, Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients., Pharmacogenet Genomics
Choi Y et al., 2017, A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET<sup>TM</sup> Plus platform., Pharmacogenomics J
Bruckmueller H et al., 2015, Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus., Ther Drug Monit
De Mattia E et al., 2016, Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine., Pharmacogenomics
Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
Castillo-Mancilla JR et al., 2016, Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342)., J Antimicrob Chemother
Bonora S et al., 2015, Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study)., J Antimicrob Chemother
Schipani A et al., 2010, Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance., Antimicrob Agents Chemother
Siccardi M et al., 2008, Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir., Clin Infect Dis
Andrews E et al., 2010, A role for the pregnane X receptor in flucloxacillin-induced liver injury., Hepatology
Mbatchi LC et al., 2016, Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients., Clin Pharmacokinet
Noetzli M et al., 2013, Population pharmacokinetic study of memantine: effects of clinical and genetic factors., Clin Pharmacokinet
Ferraresso M et al., 2013, Long-term effects of ABCB1 and SXR SNPs on the systemic exposure to cyclosporine in pediatric kidney transplant patients., Pharmacogenomics
Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Di Leva FS et al., 2013, Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands., J Med Chem
Narjoz C et al., 2015, Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients., Invest New Drugs

RIFAXIMIN NR1I2

Interaction Score: 3.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
21141967 22126372 24388834 24828006 17442842 20627999

Sources:
DTC
SOLOMONSTEROL A NR1I2

Interaction Score: 1.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21141967 24828006

Sources:
DTC
MENATETRENONE NR1I2

Interaction Score: 1.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21618996 21561094

Sources:
DTC
THEONELLASTEROL H NR1I2

Interaction Score: 1.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
OXICONAZOLE NR1I2

Interaction Score: 1.13

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
17998298

Sources:
PharmGKB
THEONELLASTEROL D NR1I2

Interaction Score: 1.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
SOLOMONSTEROL B NR1I2

Interaction Score: 1.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21141967

Sources:
DTC
THEONELLASTEROL G NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
SUVANINE'S SODIUM SALT NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23656455

Sources:
DTC
CONICASTEROL D NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
THEONELLASTEROL F NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
RIFABUTIN NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CONICASTEROL B NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
NAFCILLIN NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
THEONELLASTEROL B NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
HYPERFORIN NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17016423 17139284

Sources:
GuideToPharmacology
CONICASTEROL E NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22126372

Sources:
DTC
THEONELLASTEROL C NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
AMG-232 NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24456472

Sources:
DTC
THEONELLASTEROL E NR1I2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21428459

Sources:
DTC
ECONAZOLE NR1I2

Interaction Score: 0.38

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
17998298

Sources:
PharmGKB
CHEMBL398412 NR1I2

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21956953

Sources:
DTC
ATAZANAVIR NR1I2

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26892777 26174719 20921307 18831695

Sources:
PharmGKB
DEMECLOCYCLINE NR1I2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHEMBL535714 NR1I2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PERMETHRIN NR1I2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21115097

Sources:
PharmGKB
SULFAMETHAZINE NR1I2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RIFAPENTINE NR1I2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MEMANTINE NR1I2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23371894

Sources:
PharmGKB
TROLEANDOMYCIN NR1I2

Interaction Score: 0.23

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
15039302

Sources:
PharmGKB
RIFAMPIN NR1I2

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17925385 19460945 16480505 21561094 25537531

Sources:
DTC GuideToPharmacology PharmGKB
CEFADROXIL NR1I2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CLINDAMYCIN NR1I2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TERBINAFINE NR1I2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METYRAPONE NR1I2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLOXACILLIN NR1I2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20222094

Sources:
PharmGKB
CHENODIOL NR1I2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17963371

Sources:
DTC
SULFISOXAZOLE NR1I2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CEFUROXIME NR1I2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
GRISEOFULVIN NR1I2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CEPHRADINE NR1I2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
BOSENTAN NR1I2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DICLOXACILLIN NR1I2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IFOSFAMIDE NR1I2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18839173

Sources:
PharmGKB
CEPHALEXIN NR1I2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LITHOCHOLIC ACID NR1I2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17963371

Sources:
DTC
DOLUTEGRAVIR NR1I2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CLOTRIMAZOLE NR1I2

Interaction Score: 0.1

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
14977870 20869355 15849716 17998298

Sources:
GuideToPharmacology PharmGKB
SULFINPYRAZONE NR1I2

Interaction Score: 0.09

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
14977870

Sources:
PharmGKB
RITONAVIR NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
14977870 15849716

Sources:
PharmGKB
TACROLIMUS NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29733390 28777242 26882121 25271728

Sources:
PharmGKB
MICONAZOLE NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
17998298

Sources:
PharmGKB
CYPROTERONE NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ISRADIPINE NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ARTEMISININ NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TEMSIROLIMUS NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28676933

Sources:
PharmGKB
REPAGLINIDE NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23807564

Sources:
PharmGKB
DIETHYLSTILBESTROL NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26408814 16054614

Sources:
DTC PharmGKB
MINOCYCLINE NR1I2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SAQUINAVIR NR1I2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
COLFORSIN NR1I2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PHENOBARBITAL NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
15039302 14977870

Sources:
GuideToPharmacology PharmGKB
FLUTAMIDE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18839173

Sources:
PharmGKB
SPIRONOLACTONE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16054614

Sources:
PharmGKB
MODAFINIL NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
BEXAROTENE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
MIFEPRISTONE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
16054614

Sources:
GuideToPharmacology
AMPICILLIN NR1I2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CARBAMAZEPINE NR1I2

Interaction Score: 0.05

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
23252947 21738081 14977870

Sources:
PharmGKB
BUDESONIDE NR1I2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PHENYLBUTAZONE NR1I2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ISONIAZID NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PHENYTOIN NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14977870 15039302

Sources:
PharmGKB
DOXYCYCLINE NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CEFACLOR NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NICARDIPINE NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TETRACYCLINE NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PIOGLITAZONE NR1I2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
AMOXICILLIN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IRINOTECAN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27561454 27116457

Sources:
PharmGKB
NIFEDIPINE NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
21291553

Sources:
GuideToPharmacology PharmGKB
GLYBURIDE NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METFORMIN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22722338

Sources:
PharmGKB
TAMOXIFEN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16054614 18839173

Sources:
PharmGKB
ERYTHROMYCIN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
EFAVIRENZ NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUVASTATIN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RISPERIDONE NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26129906 23609392

Sources:
PharmGKB
SUNITINIB NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25344452

Sources:
PharmGKB
LOVASTATIN NR1I2

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology PharmGKB
NEVIRAPINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PACLITAXEL NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
18839173 21151855

Sources:
GuideToPharmacology PharmGKB
RESERPINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LANSOPRAZOLE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TROGLITAZONE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ROSIGLITAZONE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOCETAXEL NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
24193570 15492266

Sources:
PharmGKB
METHADONE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SIROLIMUS NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28676933

Sources:
PharmGKB
CYCLOSPORINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24088131

Sources:
PharmGKB
VINBLASTINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHLORPROMAZINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
OMEPRAZOLE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROCORTISONE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CYCLOPHOSPHAMIDE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18839173

Sources:
PharmGKB
DEXAMETHASONE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16054614

Sources:
PharmGKB
TOPIRAMATE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOXORUBICIN NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27561454

Sources:
PharmGKB
SIMVASTATIN NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
VINCRISTINE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ATORVASTATIN NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PROGESTERONE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CISPLATIN NR1I2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000144852
- Version: 101_38
Alternate Names:

NR1I2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000144852

Version: 26-July-2011

Alternate Names:

ORPHAN NUCLEAR RECEPTOR PXR (PREGNANE X RECEPTOR) (ORPHAN NUCLEAR RECEPTOR PAR1) (STEROID AND XENOBIOTIC RECEPTOR) (SXR). [SOURCE:UNIPROT/SWISSPROT;ACC:O75469] Description

ENSG00000144852 Ensembl Gene Id

NR1I2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: NR1I2
- Version: February-2014
Alternate Names:

8856 Entrez Gene ID

Gene Info:

Initial Gene Query NR1I2

Counted Citations from 1950-2000 1454

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: O75469
- Version: 11-September-2012
Alternate Names:

8856 Entrez Gene Id

ENSG00000144852 Ensembl Gene Id

NR1I2_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Name Nuclear hormone receptor, ligand-binding, core

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 8856
- Version: 29-September-2020
Alternate Names:

7968 HUGO Gene ID

7968 HUGO Gene Symbol

nuclear receptor subfamily 1 group I member 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1I. Vitamin D receptor-like receptors

GuideToPharmacology Gene Category ID 90

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

PharmGKB: NR1I2

Version: 18-August-2020

Alternate Names:

PA378 PharmGKB ID

Gene Info:

Publications:

Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol

Castillo-Mancilla JR et al., 2016, Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342)., J Antimicrob Chemother

Bonora S et al., 2015, Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study)., J Antimicrob Chemother

DTC: NR1I2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Festa C et al., 2011, Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity., J Med Chem

De Marino S et al., 2011, Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors., J Med Chem

Sun D et al., 2014, Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development., J Med Chem

HingoraniCasas: ENSG00000144852
- Version: 31-May-2017
Alternate Names:

ENSG00000144852 Gene Symbol

NR1I2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: NR1I2
- Version: 27-Jun-2013
Alternate Names:

8856 Gene ID

BXR dGene Synonym

ONR1 dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
GO: NR1I2
- Version: 01-May-2021
Alternate Names:

PXR GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
Pharos: NR1I2
- Version: 01-May-2021
Alternate Names:

Nuclear receptor subfamily 1 group I member 2 Gene Name

O75469 UniProt ID

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

Publications:

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

ORPHAN NUCLEAR RECEPTOR PXR (PREGNANE X RECEPTOR) (ORPHAN NUCLEAR RECEPTOR PAR1) (STEROID AND XENOBIOTIC RECEPTOR) (SXR). [SOURCE:UNIPROT/SWISSPROT;ACC:O75469]	Description
ENSG00000144852	Ensembl Gene Id
NR1I2	Display Id

8856	Entrez Gene Id
ENSG00000144852	Ensembl Gene Id
NR1I2_HUMAN	Uniprot Id

7968	HUGO Gene ID
7968	HUGO Gene Symbol
nuclear receptor subfamily 1 group I member 2	HUGO Gene Name

Nuclear receptor subfamily 1 group I member 2	Gene Name
O75469	UniProt ID

NR1I2 Gene Record

NR1I2 8856 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 21141967 22126372 24388834 24828006 17442842 20627999

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21141967 24828006

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21618996 21561094

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: partial agonist (activating)

Interaction Info:

PMIDs: 17998298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21141967

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23656455

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: 17016423 17139284

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22126372

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21428459

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

PMIDs:
21141967 22126372 24388834 24828006 17442842 20627999

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21141967 24828006

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21618996 21561094

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
17998298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21141967

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23656455

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17016423 17139284

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22126372

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24456472

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21428459

Sources:
DTC

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
17998298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21956953

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26892777 26174719 20921307 18831695

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21115097

Sources:
PharmGKB

Interaction Types & Directionality:

n/a