DGIdb - NR3C1 Gene Record

NR3C1 2908 Druggable Genome

Alternate Names:

2908
NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1
NR3C1
GCCR
GCR
GCRST
GR
GRL
138040
7978
ENSG00000113580
OTTHUMG00000129677
P04150
GCR_HUMAN
GLUCOCORTICOID RECEPTOR
GLUCOCORTICOID RECEPTOR (GR). [SOURCE:UNIPROT/SWISSPROT;ACC:P04150]
T40016

Gene Info:

Target Main Class	Receptors
Target Subclass	Nuclear receptor
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Initial Gene Query	NR3C1
Counted Citations from 1950-2000	8469
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000536
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Interpro Type	Domain
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Henriksson et al., Effects of topical budesonide treatment on glucocorticoid receptor mRNA down-regulation and cytokine patterns in nasal polyps., Am J Rhinol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kompella et al., 2003, Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression., Invest. Ophthalmol. Vis. Sci.
Kunz et al., 2003, Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells., Mol. Endocrinol.
Zhang et al., 2000, Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone., Eur. J. Pharmacol.
Zhang et al., 2001, Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis., Eur. J. Pharmacol.
Grossman et al., 2006, Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects., Ann. N. Y. Acad. Sci.
Sher, 2006, Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior., ScientificWorldJournal
Rautanen et al., 2006, Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene., J. Clin. Endocrinol. Metab.
Hammer et al., 2006, Cortisol metabolism in hypertension., Best Pract. Res. Clin. Endocrinol. Metab.
Lange et al., Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids., Skin Pharmacol. Appl. Skin Physiol.
Shaw et al., 2007, Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
CHADFIELD HW, 1963, CORTICOSTEROID THERAPY IN CURRENT DERMATOLOGICAL PRACTICE., Postgrad Med J
Nishizaki Y et al., 2009, Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay., Bioorg Med Chem Lett
Hochhaus et al., 1990, Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue., Agents Actions
Fitzgerald et al., 2006, Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression., Psychol Med
Issar et al., 2006, Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids., Eur. Respir. J.
Baschant et al., 2010, The role of the glucocorticoid receptor in inflammation and immunity., J. Steroid Biochem. Mol. Biol.
Pearce et al., 2004, Class I topical corticosteroid use by psoriasis patients in an academic practice., J Dermatolog Treat
Schlechte et al., 1982, Decreased glucocorticoid receptor binding in adrenal insufficiency., J. Clin. Endocrinol. Metab.
Schlechte et al., 1982, Regulation of the glucocorticoid receptor in human lymphocytes., J. Steroid Biochem.
Lumry, 1999, A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis., J. Allergy Clin. Immunol.
Isogai et al., 1993, Binding affinities of mometasone furoate and related compounds including its metabolites for the glucocorticoid receptor of rat skin tissue., J. Steroid Biochem. Mol. Biol.
Smith et al., 1998, In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids., Arzneimittelforschung
Zhang et al., 2002, Divergent effect of mometasone on human eosinophil and neutrophil apoptosis., Life Sci.
Nehmé et al., 2009, Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells., BMC Med Genomics
Shahin et al., 2005, Glucocorticoids remodel nuclear envelope structure and permeability., J. Cell. Sci.
Badia et al., 2001, Topical corticosteroids in nasal polyposis., Drugs
Philibert et al., 1993, [Pharmacologic study of the glucocorticoid activity of flunisolide compared with other steroids in the rat]., Allerg Immunol (Paris)
Högger et al., 1998, Biochemical characterization of a glucocorticoid-induced membrane protein (RM3/1) in human monocytes and its application as model system for ranking glucocorticoid potency., Pharm. Res.
Johnson, 1998, Development of fluticasone propionate and comparison with other inhaled corticosteroids., J. Allergy Clin. Immunol.
Valotis et al., 2004, Significant receptor affinities of metabolites and a degradation product of mometasone furoate., Respir. Res.
Boudinot et al., 1986, Receptor-mediated pharmacodynamics of prednisolone in the rat., J Pharmacokinet Biopharm
Ikonomidis et al., 2009, Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis., Heart
Schuster D et al., 2006, The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening., J Med Chem
Czock D et al., 2005, Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids., Clin Pharmacokinet
Barnes, 2007, The properties of inhaled corticosteroids: similarities and differences., Prim Care Respir J
Simmons L et al., 2011, Bendigoles D-F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009., Bioorg Med Chem
Owen et al., 2007, The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438., Mol. Cell. Endocrinol.
Quesnell et al., 2007, Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium., Am. J. Physiol., Cell Physiol.
Juruena et al., 2006, Different responses to dexamethasone and prednisolone in the same depressed patients., Psychopharmacology (Berl.)
Boivin et al., 2007, Mechanism of glucocorticoid regulation of the intestinal tight junction barrier., Am. J. Physiol. Gastrointest. Liver Physiol.
Samudre et al., 2004, Comparison of topical steroids for acute anterior uveitis., J Ocul Pharmacol Ther
Mayer et al., 1975, Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol., Am. J. Physiol.
Wang et al., 2007, Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor., Am. J. Physiol., Cell Physiol.
Funato et al., 2006, Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor., Brain Res.
Vaitkuviene et al., Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from the rat liver., Pharmacol Rep
Warne et al., 2006, Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue., Am. J. Physiol. Endocrinol. Metab.
Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother
Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
Jessop et al., 2001, Drugs for discoid lupus erythematosus., Cochrane Database Syst Rev
Friel et al., 2006, Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases., Altern Med Rev
Liu et al., 2006, [Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Yano et al., 2006, Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells., Clin. Cancer Res.
Díez et al., 2007, Pharmacological therapy of Cushing's syndrome: drugs and indications., Mini Rev Med Chem
Yano et al., 2006, Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells., Clin. Cancer Res.
Zhang et al., 1997, Pulmonary phospholipid saturation increases with glucocorticoid receptor mRNAs in late gestation but not due to labor in the fetal rhesus monkey., Prostaglandins Leukot. Essent. Fatty Acids
Tanigawa et al., 2002, Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters., Int. Immunopharmacol.
Buchwald, 2008, Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model., Steroids
Ali et al., 2008, Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat., Bioorg. Med. Chem.
Southren et al., 1983, Nuclear translocation of the cytoplasmic glucocorticoid receptor in the iris-ciliary body and adjacent corneoscleral tissue of the rabbit following topical administration of various glucocorticoids. A rapid screening method for glucocorticoid activity., Invest. Ophthalmol. Vis. Sci.
LeVan et al., 1999, Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells., Biochem. Pharmacol.
Gu et al., 2005, Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis., Apoptosis
de Pablos et al., 2006, Stress increases vulnerability to inflammation in the rat prefrontal cortex., J. Neurosci.
Aida et al., 2004, The effects of betamethasone (BM) on endothelial nitric oxide synthase (eNOS) expression in adult baboon femoral arterial endothelial cells., J. Steroid Biochem. Mol. Biol.
Attardi et al., 2004, In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone., J. Steroid Biochem. Mol. Biol.
Möllmann H et al., 1995, Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone., Pharm Res
Russell et al., 2010, Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males., J. Neurosci.
Otte et al., 2010, Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study., J. Clin. Endocrinol. Metab.
Tajika et al., 2010, Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion., Xenobiotica
Jamal et al., 2009, The role of difluprednate ophthalmic emulsion in clinical practice., Clin Ophthalmol
Hofmann et al., 1998, Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription., FEBS Lett.
Labeur et al., 2010, Molecular mechanisms of glucocorticoid receptor signaling., Medicina (B Aires)
Johnstone et al., 2005, The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta., J. Soc. Gynecol. Investig.
Sharma R et al., 2011, Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators., J Med Chem
Miner JN et al., 2007, Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile., Proc Natl Acad Sci U S A
Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett
Gupta et al., 2003, Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus., J. Endocrinol.
Leo JC et al., 2004, Glucocorticoid and mineralocorticoid cross-talk with progesterone receptor to induce focal adhesion and growth inhibition in breast cancer cells., Endocrinology
Xu XF et al., 1990, Progestin binds to the glucocorticoid receptor and mediates antiglucocorticoid effect in rat adipose precursor cells., J Steroid Biochem
Attardi et al., 2007, Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins., Am. J. Obstet. Gynecol.
Wilson VS et al., 2002, A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists., Toxicol Sci
Abida et al., 2002, Receptor-dependence of the transcription read-out in a small-molecule three-hybrid system., Chembiochem

CORTISONE ACETATE NR3C1

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
16891588 7054210 17086345 7062741 16895953 16980198 17038445

Sources:
ChemblInteractions
MOMETASONE NR3C1

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CRx-191

Novel drug target Established target

Trial Name mometasone furoate + formoterol fumarate dihydrate,Dulera

PMIDs:
10518812 8439518 9793625 12127907 11752352

Sources:
TdgClinicalTrial TEND TTD
PARAMETHASONE NR3C1

Interaction Score: 1.69

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16255837 16891588 17086345 16895953 16980198 17038445

Sources:
TdgClinicalTrial
FLUOROMETHOLONE NR3C1

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
15684812 16891588 17086345 16895953 16980198 17038445

Sources:
TdgClinicalTrial ChemblInteractions TTD
HYDROCORTAMATE NR3C1

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 14046902

Sources:
TdgClinicalTrial TEND TTD
CHEMBL210411 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19592245

Sources:
DTC
CHEMBL1915269 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21684166

Sources:
DTC
CORT 125134 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL259820 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18032610

Sources:
DTC
MAPRACORAT NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
FLUTICASONE FUROATE NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
FLUTICASONE NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Dymista, azelastine hydrochloride + fluticasone propionate, MP29-02

Novel drug target Established target

Trial Name Fluticasone

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
CHEMBL1915270 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21684166

Sources:
DTC
CHEMBL1275761 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20308375

Sources:
DTC
ORG-34517 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL1915271 NR3C1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21684166

Sources:
DTC
DIFLUPREDNATE NR3C1

Interaction Score: 0.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name difluprednate , ST-601,Durezol

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
20509750 19668594

Sources:
TdgClinicalTrial ChemblInteractions TEND
DESONIDE NR3C1

Interaction Score: 0.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name desonide,Desonate HydroGel

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
20427668 17038445 20371666

Sources:
TdgClinicalTrial ChemblInteractions
FLURANDRENOLIDE NR3C1

Interaction Score: 0.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

Trial Name -

PMIDs:
16255837 16507850 20346397

Sources:
TdgClinicalTrial ChemblInteractions
DESOXIMETASONE NR3C1

Interaction Score: 0.77

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
16891588 17086345 16895953 16980198 10754457 17038445

Sources:
TdgClinicalTrial ChemblInteractions
DEFLAZACORT NR3C1

Interaction Score: 0.72

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
7494809

Sources:
ChemblInteractions TTD
AMCINONIDE NR3C1

Interaction Score: 0.69

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

Trial Name -

PMIDs:
16891588 17086345 16895953 16980198 17016423 17139284 17038445

Sources:
TdgClinicalTrial ChemblInteractions TEND
CLOCORTOLONE NR3C1

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12188035 18022656 18691892

Sources:
TdgClinicalTrial
MEDRYSONE NR3C1

Interaction Score: 0.6

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
11752352 6336597 15634032

Sources:
TdgClinicalTrial ChemblInteractions
FLUNISOLIDE NR3C1

Interaction Score: 0.53

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name flunisolide,Aerobid

Novel drug target Established target

Trial Name flunisolide HFA,Aerospan

PMIDs:
11368283 8466638 2386110 11752352 9523318 9563368 15285788

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BETAMETHASONE ACETATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CORT 108297 NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCORTAMATE HYDROCHLORIDE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BETAMETHASONE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name betamethasone valerate 0.12% topical foam,BetMetFoam

PMIDs:
15866114 15336699 11752352 12188035

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
ALCLOMETASONE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9891987 20920967

Sources:
TdgClinicalTrial
DEXAMETHASONE ACETATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUOROMETHOLONE ACETATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUOCINONIDE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

Trial Name fluocinonide,Vanos

PMIDs:
11279785

Sources:
TdgClinicalTrial ChemblInteractions
PREDNISOLONE TEBUTATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DAGROCORAT NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUTICASONE PROPIONATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREDNISOLONE SODIUM PHOSPHATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OUABAIN NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMCINOLONE HEXACETONIDE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
CICLESONIDE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
17530144

Sources:
TdgClinicalTrial ChemblInteractions
MEPREDNISONE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
HYDROCORTISONE CYPIONATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PREDNICARBATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

Trial Name -

PMIDs:
2879901 19482847

Sources:
TdgClinicalTrial ChemblInteractions
HE3286 NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Triolex

PMIDs:
None found

Sources:
TdgClinicalTrial
FOSDAGROCORAT NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLPREDNISOLONE ACETATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BETAMETHASONE BENZOATE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BUDESONIDE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name budesonide + formoterol,Symbicort

Novel drug target Established target

Trial Name budesonide inhalation suspension,Pulmicort Respules

PMIDs:
11258648 11752352 12601049 12920235 11040338 11730731

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
CHEMBL2059711 NR3C1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24915879

Sources:
DTC
URSODIOL NR3C1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21158453

Sources:
DTC
FLUOXYMESTERONE NR3C1

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
173192

Sources:
DTC
DIFLORASONE NR3C1

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15764038

Sources:
TdgClinicalTrial
ALDOSTERONE NR3C1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16759088 11861974

Sources:
DTC
RIMEXOLONE NR3C1

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
2386110

Sources:
TdgClinicalTrial ChemblInteractions
METHYLPREDNISOLONE NR3C1

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
17182172 17251323 17016711 11752352 17068119

Sources:
TdgClinicalTrial ChemblInteractions TEND
FLUMETHASONE PIVALATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUPREDNISOLONE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLPREDNISOLONE SODIUM SUCCINATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOBETASOL PROPIONATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
FLUOCINOLONE ACETONIDE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCORTISONE PROBUTATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BETAMETHASONE DIPROPIONATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEXAMETHASONE SODIUM PHOSPHATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
BETAMETHASONE VALERATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCORTISONE ACETATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BETAMETHASONE SODIUM PHOSPHATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PARAMETHASONE ACETATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALCLOMETASONE DIPROPIONATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
TRIAMCINOLONE DIACETATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCORTISONE SODIUM PHOSPHATE NR3C1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
MIFEPRISTONE NR3C1

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Mifepristone, RU486

Novel drug target Established target

Trial Name mifepristone,Corlux

PMIDs:
10796070 15909120 16723527 15336699 15120421

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
PREDNISONE NR3C1

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name ATL-2502,Colal-Pred

PMIDs:
16597193 17121036 16707595 17504182 11752352 17062674 15634032

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
HALCINONIDE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LOTEPREDNOL ETABONATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIFLORASONE DIACETATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLOCORTOLONE PIVALATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREDNISOLONE ACETATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRIAMCINOLONE ACETONIDE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANDROSTENEDIONE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9384522

Sources:
DTC NCI
HYDROCORTISONE VALERATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CYPROTERONE ACETATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOBETASOL PROPIONATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCORTISONE SODIUM SUCCINATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCORTISONE BUTYRATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
BECLOMETHASONE DIPROPIONATE NR3C1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRIAMCINOLONE NR3C1

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name triamcinolone acetonide implant,I-vation

PMIDs:
19744340 16507850 15976447

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
HYDROCORTISONE NR3C1

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
16891588 16895953 16980198 17038445 17086345 16759088 15634032

Sources:
DTC ChemblInteractions TTD
CLOBETASOL NR3C1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name clobetasol propionate,Olux Foam

PMIDs:
None found

Sources:
TdgClinicalTrial
PREDNISOLONE NR3C1

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name CRx-102, prednisolone plus dipyridamole ,Synavive

PMIDs:
2879901 19482847

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
POTASSIUM DICHROMATE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBUTYLDICHLOROSTANNANE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOMETASONE FUROATE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TESTOSTERONE PROPIONATE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENACYL CHLORIDE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLTESTOSTERONE NR3C1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STANOLONE NR3C1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BECLOMETHASONE NR3C1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name beclometasone, CHF-1514, /

Novel drug target Established target

Trial Name beclomethasone dipropionate, BDP HFA,Qvar, Qnaze

PMIDs:
None found

Sources:
DTC TdgClinicalTrial
E-GUGGULSTERONE NR3C1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXAMETHASONE NR3C1

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name dexamethasone intravitreal implant,Ozurdex, Posurdex

Novel drug target Established target

Trial Name EGP-437

PMIDs:
16971495 16956592 16891588 16963802 16835395 11752352 20308375 23276449

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
CHRYSIN NR3C1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19592245

Sources:
DTC
PHENOLPHTHALEIN NR3C1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
3R14S-OCHRATOXIN A NR3C1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRADIOL NR3C1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12553866

Sources:
DTC NCI
BENZO(K)FLUORANTHENE NR3C1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ETHINYL ESTRADIOL NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPYLPYRAZOLETRIOL NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KEPONE NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BAICALEIN NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19592245

Sources:
DTC
ZEARALENONE NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PENTABROMOPHENOL NR3C1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOHEXIMIDE NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL184450 NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTINOMYCIN NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROGESTERONE NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
14617569 2214763 18060946

Sources:
DTC
DIGITOXIN NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLIOQUINOL NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENYLMERCURIC ACETATE NR3C1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CATECHOL NR3C1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RALOXIFENE HYDROCHLORIDE NR3C1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APIGENIN NR3C1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW7647 NR3C1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZACITIDINE NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGOXIN NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TESTOSTERONE NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBAMAZEPINE NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFEDIPINE NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHOTREXATE NR3C1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12210990

Sources:
NCI

Ensembl: ENSG00000113580
- Version: 101_38
Alternate Names:

NR3C1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P04150
- Version: 01-August-2011
Alternate Names:

GCR_HUMAN Uniprot Id

NR3C1 Gene Symbol

ENSG00000113580 Ensembl Gene Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Publications:
RussLampel: ENSG00000113580
- Version: 26-July-2011
Alternate Names:

ENSG00000113580 Ensembl Gene Id

GLUCOCORTICOID RECEPTOR (GR). [SOURCE:UNIPROT/SWISSPROT;ACC:P04150] Description

NR3C1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P04150
- Version: January-2014
Alternate Names:

NR3C1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
BaderLabGenes: NR3C1
- Version: February-2014
Alternate Names:

2908 Entrez Gene ID

Gene Info:

Initial Gene Query NR3C1

Counted Citations from 1950-2000 8469

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P04150
- Version: 11-September-2012
Alternate Names:

GCR_HUMAN Uniprot Id

ENSG00000113580 Ensembl Gene Id

NR3C1 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Human Readable Name NUCLEAR HORMONE RECEPTOR

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TTD: Glucocorticoid receptor
- Version: 2020.06.01
Alternate Names:

NR3C1 TTD Gene Abbreviation

T40016 TTD Target ID

Gene Info:

Publications:

Valdman-Grinshpoun Y et al., 2012, Barrier-restoring therapies in atopic dermatitis: current approaches and future perspectives., Dermatol Res Pract

NCI: NR3C1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Zhang et al., 1997, Pulmonary phospholipid saturation increases with glucocorticoid receptor mRNAs in late gestation but not due to labor in the fetal rhesus monkey., Prostaglandins Leukot. Essent. Fatty Acids

Fernández et al., 1995, [3H]dexamethasone binding activity in liver microsomes is modulated differently by 17 alpha-alkylated androgens and testosterone in vivo., Pharmacol. Toxicol.

Choi et al., 2006, Expression of glucocorticoid receptor mRNAs in glucocorticoid-resistant nasal polyps., Exp. Mol. Med.

DTC: NR3C1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother

Nishizaki Y et al., 2009, Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay., Bioorg Med Chem Lett

Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000113580
- Version: 31-May-2017
Alternate Names:

ENSG00000113580 Gene Symbol

NR3C1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GRL
- Version: chembl_23
Alternate Names:

GRL GENE_SYMBOL

NR3C1 GENE_SYMBOL

Glucocorticoid receptor UNIPROT

Gene Info:

Publications:
GO: NR3C1
- Version: 01-February-2022
Alternate Names:

GRL GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: NR3C1
- Version: 27-Jun-2013
Alternate Names:

2908 Gene ID

GCCR dGene Synonym

GCR dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
Pharos: NR3C1
- Version: 01-February-2022
Alternate Names:

Glucocorticoid receptor Gene Name

P04150 UniProt ID

Gene Info:

Gene Categories:

ENZYME, TRANSCRIPTION FACTOR

Publications:

Mechanism of Interaction	Glucocorticoid receptor agonist
Direct Interaction	yes

Trial Name	CRx-191
Novel drug target	Established target
Trial Name	mometasone furoate + formoterol fumarate dihydrate,Dulera

Mechanism of Interaction	Glucocorticoid receptor antagonist
Direct Interaction	yes

Trial Name	Dymista, azelastine hydrochloride + fluticasone propionate, MP29-02
Novel drug target	Established target
Trial Name	Fluticasone

Trial Name	difluprednate , ST-601,Durezol
Novel drug target	Established target
Mechanism of Interaction	Glucocorticoid receptor agonist

Trial Name	desonide,Desonate HydroGel
Novel drug target	Established target
Mechanism of Interaction	Glucocorticoid receptor agonist

Trial Name	flunisolide,Aerobid
Novel drug target	Established target
Trial Name	flunisolide HFA,Aerospan

Mechanism of Interaction	Glucocorticoid receptor modulator
Direct Interaction	yes

Trial Name	budesonide + formoterol,Symbicort
Novel drug target	Established target
Trial Name	budesonide inhalation suspension,Pulmicort Respules

Trial Name	Mifepristone, RU486
Novel drug target	Established target
Trial Name	mifepristone,Corlux

Trial Name	beclometasone, CHF-1514, /
Novel drug target	Established target
Trial Name	beclomethasone dipropionate, BDP HFA,Qvar, Qnaze

Trial Name	dexamethasone intravitreal implant,Ozurdex, Posurdex
Novel drug target	Established target
Trial Name	EGP-437

GCR_HUMAN	Uniprot Id
NR3C1	Gene Symbol
ENSG00000113580	Ensembl Gene Id

GRL	GENE_SYMBOL
NR3C1	GENE_SYMBOL
Glucocorticoid receptor	UNIPROT

NR3C1 Gene Record

NR3C1 2908 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucocorticoid receptor agonist Direct Interaction yes

PMIDs: 16891588 7054210 17086345 7062741 16895953 16980198 17038445

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name CRx-191 Novel drug target Established target Trial Name mometasone furoate + formoterol fumarate dihydrate,Dulera

PMIDs: 10518812 8439518 9793625 12127907 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16255837 16891588 17086345 16895953 16980198 17038445

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs: 15684812 16891588 17086345 16895953 16980198 17038445

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 14046902

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19592245

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21684166

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glucocorticoid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18032610

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucocorticoid receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucocorticoid receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Dymista, azelastine hydrochloride + fluticasone propionate, MP29-02 Novel drug target Established target Trial Name Fluticasone

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21684166

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20308375

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glucocorticoid receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21684166

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name difluprednate , ST-601,Durezol Novel drug target Established target Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs: 20509750 19668594

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name desonide,Desonate HydroGel Novel drug target Established target Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs: 20427668 17038445 20371666

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glucocorticoid receptor agonist Trial Name -

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
16891588 7054210 17086345 7062741 16895953 16980198 17038445

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CRx-191

Novel drug target Established target

Trial Name mometasone furoate + formoterol fumarate dihydrate,Dulera

PMIDs:
10518812 8439518 9793625 12127907 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16255837 16891588 17086345 16895953 16980198 17038445

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
15684812 16891588 17086345 16895953 16980198 17038445

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 14046902

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
19592245

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21684166

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
18032610

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Dymista, azelastine hydrochloride + fluticasone propionate, MP29-02

Novel drug target Established target

Trial Name Fluticasone

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
21684166

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20308375

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
21684166

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name difluprednate , ST-601,Durezol

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
20509750 19668594

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name desonide,Desonate HydroGel

Novel drug target Established target

Mechanism of Interaction Glucocorticoid receptor agonist

PMIDs:
20427668 17038445 20371666

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

Trial Name -

PMIDs:
16255837 16507850 20346397

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
16891588 17086345 16895953 16980198 10754457 17038445

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucocorticoid receptor agonist

Direct Interaction yes

PMIDs:
7494809

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucocorticoid receptor agonist

Trial Name -