• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

NR3C1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NR3C1 2908 Druggable Genome

    Alternate Names:

    2908
    NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1
    NR3C1
    GCCR
    GCR
    GCRST
    GR
    GRL
    138040
    7978
    ENSG00000113580
    OTTHUMG00000129677
    P04150
    GCR_HUMAN
    GLUCOCORTICOID RECEPTOR
    GLUCOCORTICOID RECEPTOR (GR). [SOURCE:UNIPROT/SWISSPROT;ACC:P04150]
    T40016

    Gene Info:

    Target Main Class Receptors
    Target Subclass Nuclear receptor
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Initial Gene Query NR3C1
    Counted Citations from 1950-2000 8469
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000536
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Type Domain
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Henriksson et al., Effects of topical budesonide treatment on glucocorticoid receptor mRNA down-regulation and cytokine patterns in nasal polyps., Am J Rhinol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kompella et al., 2003, Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression., Invest. Ophthalmol. Vis. Sci.
    Kunz et al., 2003, Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells., Mol. Endocrinol.
    Zhang et al., 2000, Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone., Eur. J. Pharmacol.
    Zhang et al., 2001, Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis., Eur. J. Pharmacol.
    Grossman et al., 2006, Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects., Ann. N. Y. Acad. Sci.
    Sher, 2006, Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior., ScientificWorldJournal
    Rautanen et al., 2006, Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene., J. Clin. Endocrinol. Metab.
    Hammer et al., 2006, Cortisol metabolism in hypertension., Best Pract. Res. Clin. Endocrinol. Metab.
    Lange et al., Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids., Skin Pharmacol. Appl. Skin Physiol.
    Shaw et al., 2007, Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    CHADFIELD HW, 1963, CORTICOSTEROID THERAPY IN CURRENT DERMATOLOGICAL PRACTICE., Postgrad Med J
    Nishizaki Y et al., 2009, Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay., Bioorg Med Chem Lett
    Hochhaus et al., 1990, Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue., Agents Actions
    Fitzgerald et al., 2006, Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression., Psychol Med
    Issar et al., 2006, Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids., Eur. Respir. J.
    Baschant et al., 2010, The role of the glucocorticoid receptor in inflammation and immunity., J. Steroid Biochem. Mol. Biol.
    Pearce et al., 2004, Class I topical corticosteroid use by psoriasis patients in an academic practice., J Dermatolog Treat
    Schlechte et al., 1982, Decreased glucocorticoid receptor binding in adrenal insufficiency., J. Clin. Endocrinol. Metab.
    Schlechte et al., 1982, Regulation of the glucocorticoid receptor in human lymphocytes., J. Steroid Biochem.
    Lumry, 1999, A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis., J. Allergy Clin. Immunol.
    Isogai et al., 1993, Binding affinities of mometasone furoate and related compounds including its metabolites for the glucocorticoid receptor of rat skin tissue., J. Steroid Biochem. Mol. Biol.
    Smith et al., 1998, In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids., Arzneimittelforschung
    Zhang et al., 2002, Divergent effect of mometasone on human eosinophil and neutrophil apoptosis., Life Sci.
    Nehmé et al., 2009, Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells., BMC Med Genomics
    Shahin et al., 2005, Glucocorticoids remodel nuclear envelope structure and permeability., J. Cell. Sci.
    Badia et al., 2001, Topical corticosteroids in nasal polyposis., Drugs
    Philibert et al., 1993, [Pharmacologic study of the glucocorticoid activity of flunisolide compared with other steroids in the rat]., Allerg Immunol (Paris)
    Högger et al., 1998, Biochemical characterization of a glucocorticoid-induced membrane protein (RM3/1) in human monocytes and its application as model system for ranking glucocorticoid potency., Pharm. Res.
    Johnson, 1998, Development of fluticasone propionate and comparison with other inhaled corticosteroids., J. Allergy Clin. Immunol.
    Valotis et al., 2004, Significant receptor affinities of metabolites and a degradation product of mometasone furoate., Respir. Res.
    Boudinot et al., 1986, Receptor-mediated pharmacodynamics of prednisolone in the rat., J Pharmacokinet Biopharm
    Ikonomidis et al., 2009, Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis., Heart
    Schuster D et al., 2006, The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening., J Med Chem
    Czock D et al., 2005, Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids., Clin Pharmacokinet
    Barnes, 2007, The properties of inhaled corticosteroids: similarities and differences., Prim Care Respir J
    Simmons L et al., 2011, Bendigoles D-F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009., Bioorg Med Chem
    Owen et al., 2007, The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438., Mol. Cell. Endocrinol.
    Quesnell et al., 2007, Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium., Am. J. Physiol., Cell Physiol.
    Juruena et al., 2006, Different responses to dexamethasone and prednisolone in the same depressed patients., Psychopharmacology (Berl.)
    Boivin et al., 2007, Mechanism of glucocorticoid regulation of the intestinal tight junction barrier., Am. J. Physiol. Gastrointest. Liver Physiol.
    Samudre et al., 2004, Comparison of topical steroids for acute anterior uveitis., J Ocul Pharmacol Ther
    Mayer et al., 1975, Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol., Am. J. Physiol.
    Wang et al., 2007, Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor., Am. J. Physiol., Cell Physiol.
    Funato et al., 2006, Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor., Brain Res.
    Vaitkuviene et al., Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from the rat liver., Pharmacol Rep
    Warne et al., 2006, Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue., Am. J. Physiol. Endocrinol. Metab.
    Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother
    Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
    Jessop et al., 2001, Drugs for discoid lupus erythematosus., Cochrane Database Syst Rev
    Friel et al., 2006, Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases., Altern Med Rev
    Liu et al., 2006, [Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi
    Yano et al., 2006, Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells., Clin. Cancer Res.
    Díez et al., 2007, Pharmacological therapy of Cushing's syndrome: drugs and indications., Mini Rev Med Chem
    Yano et al., 2006, Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells., Clin. Cancer Res.
    Zhang et al., 1997, Pulmonary phospholipid saturation increases with glucocorticoid receptor mRNAs in late gestation but not due to labor in the fetal rhesus monkey., Prostaglandins Leukot. Essent. Fatty Acids
    Tanigawa et al., 2002, Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters., Int. Immunopharmacol.
    Buchwald, 2008, Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model., Steroids
    Ali et al., 2008, Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat., Bioorg. Med. Chem.
    Southren et al., 1983, Nuclear translocation of the cytoplasmic glucocorticoid receptor in the iris-ciliary body and adjacent corneoscleral tissue of the rabbit following topical administration of various glucocorticoids. A rapid screening method for glucocorticoid activity., Invest. Ophthalmol. Vis. Sci.
    LeVan et al., 1999, Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells., Biochem. Pharmacol.
    Gu et al., 2005, Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis., Apoptosis
    de Pablos et al., 2006, Stress increases vulnerability to inflammation in the rat prefrontal cortex., J. Neurosci.
    Aida et al., 2004, The effects of betamethasone (BM) on endothelial nitric oxide synthase (eNOS) expression in adult baboon femoral arterial endothelial cells., J. Steroid Biochem. Mol. Biol.
    Attardi et al., 2004, In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone., J. Steroid Biochem. Mol. Biol.
    Möllmann H et al., 1995, Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone., Pharm Res
    Russell et al., 2010, Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males., J. Neurosci.
    Otte et al., 2010, Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study., J. Clin. Endocrinol. Metab.
    Tajika et al., 2010, Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion., Xenobiotica
    Jamal et al., 2009, The role of difluprednate ophthalmic emulsion in clinical practice., Clin Ophthalmol
    Hofmann et al., 1998, Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription., FEBS Lett.
    Labeur et al., 2010, Molecular mechanisms of glucocorticoid receptor signaling., Medicina (B Aires)
    Johnstone et al., 2005, The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta., J. Soc. Gynecol. Investig.
    Sharma R et al., 2011, Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators., J Med Chem
    Miner JN et al., 2007, Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile., Proc Natl Acad Sci U S A
    Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett
    Gupta et al., 2003, Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus., J. Endocrinol.
    Leo JC et al., 2004, Glucocorticoid and mineralocorticoid cross-talk with progesterone receptor to induce focal adhesion and growth inhibition in breast cancer cells., Endocrinology
    Xu XF et al., 1990, Progestin binds to the glucocorticoid receptor and mediates antiglucocorticoid effect in rat adipose precursor cells., J Steroid Biochem
    Attardi et al., 2007, Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins., Am. J. Obstet. Gynecol.
    Wilson VS et al., 2002, A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists., Toxicol Sci
    Abida et al., 2002, Receptor-dependence of the transcription read-out in a small-molecule three-hybrid system., Chembiochem
  • CORTISONE ACETATE   NR3C1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    16891588 7054210 17086345 7062741 16895953 16980198 17038445


    Sources:
    ChemblInteractions

  • MOMETASONE   NR3C1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name CRx-191
    Novel drug target Established target
    Trial Name mometasone furoate + formoterol fumarate dihydrate,Dulera

    PMIDs:
    10518812 8439518 9793625 12127907 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • PARAMETHASONE   NR3C1

    Interaction Score: 1.69

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16255837 16891588 17086345 16895953 16980198 17038445


    Sources:
    TdgClinicalTrial

  • FLUOROMETHOLONE   NR3C1

    Interaction Score: 1.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    15684812 16891588 17086345 16895953 16980198 17038445


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • HYDROCORTAMATE   NR3C1

    Interaction Score: 1.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 14046902


    Sources:
    TdgClinicalTrial TEND TTD

  • CHEMBL210411   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19592245


    Sources:
    DTC

  • CHEMBL1915269   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21684166


    Sources:
    DTC

  • CORT 125134   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CHEMBL259820   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18032610


    Sources:
    DTC

  • MAPRACORAT   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • FLUTICASONE FUROATE   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • FLUTICASONE   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Dymista, azelastine hydrochloride + fluticasone propionate, MP29-02
    Novel drug target Established target
    Trial Name Fluticasone

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • CHEMBL1915270   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21684166


    Sources:
    DTC

  • CHEMBL1275761   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20308375


    Sources:
    DTC

  • ORG-34517   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CHEMBL1915271   NR3C1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21684166


    Sources:
    DTC

  • DIFLUPREDNATE   NR3C1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name difluprednate , ST-601,Durezol
    Novel drug target Established target
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    20509750 19668594


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DESONIDE   NR3C1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name desonide,Desonate HydroGel
    Novel drug target Established target
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    20427668 17038445 20371666


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FLURANDRENOLIDE   NR3C1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist
    Trial Name -

    PMIDs:
    16255837 16507850 20346397


    Sources:
    TdgClinicalTrial ChemblInteractions

  • DESOXIMETASONE   NR3C1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    16891588 17086345 16895953 16980198 10754457 17038445


    Sources:
    TdgClinicalTrial ChemblInteractions

  • DEFLAZACORT   NR3C1

    Interaction Score: 0.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    7494809


    Sources:
    ChemblInteractions TTD

  • AMCINONIDE   NR3C1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist
    Trial Name -

    PMIDs:
    16891588 17086345 16895953 16980198 17016423 17139284 17038445


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CLOCORTOLONE   NR3C1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12188035 18022656 18691892


    Sources:
    TdgClinicalTrial

  • MEDRYSONE   NR3C1

    Interaction Score: 0.6

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    11752352 6336597 15634032


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FLUNISOLIDE   NR3C1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name flunisolide,Aerobid
    Novel drug target Established target
    Trial Name flunisolide HFA,Aerospan

    PMIDs:
    11368283 8466638 2386110 11752352 9523318 9563368 15285788


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • BETAMETHASONE ACETATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CORT 108297   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROCORTAMATE HYDROCHLORIDE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BETAMETHASONE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name betamethasone valerate 0.12% topical foam,BetMetFoam

    PMIDs:
    15866114 15336699 11752352 12188035


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • ALCLOMETASONE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9891987 20920967


    Sources:
    TdgClinicalTrial

  • DEXAMETHASONE ACETATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUOROMETHOLONE ACETATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUOCINONIDE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist
    Trial Name fluocinonide,Vanos

    PMIDs:
    11279785


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PREDNISOLONE TEBUTATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAGROCORAT   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUTICASONE PROPIONATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PREDNISOLONE SODIUM PHOSPHATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OUABAIN   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMCINOLONE HEXACETONIDE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CICLESONIDE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    17530144


    Sources:
    TdgClinicalTrial ChemblInteractions

  • MEPREDNISONE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • HYDROCORTISONE CYPIONATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PREDNICARBATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist
    Trial Name -

    PMIDs:
    2879901 19482847


    Sources:
    TdgClinicalTrial ChemblInteractions

  • HE3286   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Triolex

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • FOSDAGROCORAT   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHYLPREDNISOLONE ACETATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BETAMETHASONE BENZOATE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUDESONIDE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name budesonide + formoterol,Symbicort
    Novel drug target Established target
    Trial Name budesonide inhalation suspension,Pulmicort Respules

    PMIDs:
    11258648 11752352 12601049 12920235 11040338 11730731


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHEMBL2059711   NR3C1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24915879


    Sources:
    DTC

  • URSODIOL   NR3C1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21158453


    Sources:
    DTC

  • FLUOXYMESTERONE   NR3C1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    173192


    Sources:
    DTC

  • DIFLORASONE   NR3C1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15764038


    Sources:
    TdgClinicalTrial

  • ALDOSTERONE   NR3C1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16759088 11861974


    Sources:
    DTC

  • RIMEXOLONE   NR3C1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    2386110


    Sources:
    TdgClinicalTrial ChemblInteractions

  • METHYLPREDNISOLONE   NR3C1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    17182172 17251323 17016711 11752352 17068119


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • FLUMETHASONE PIVALATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUPREDNISOLONE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHYLPREDNISOLONE SODIUM SUCCINATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HALOBETASOL PROPIONATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUOCINOLONE ACETONIDE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROCORTISONE PROBUTATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BETAMETHASONE DIPROPIONATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DEXAMETHASONE SODIUM PHOSPHATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BETAMETHASONE VALERATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROCORTISONE ACETATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BETAMETHASONE SODIUM PHOSPHATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PARAMETHASONE ACETATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALCLOMETASONE DIPROPIONATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIAMCINOLONE DIACETATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROCORTISONE SODIUM PHOSPHATE   NR3C1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIFEPRISTONE   NR3C1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Mifepristone, RU486
    Novel drug target Established target
    Trial Name mifepristone,Corlux

    PMIDs:
    10796070 15909120 16723527 15336699 15120421


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TTD

  • PREDNISONE   NR3C1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name ATL-2502,Colal-Pred

    PMIDs:
    16597193 17121036 16707595 17504182 11752352 17062674 15634032


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • HALCINONIDE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LOTEPREDNOL ETABONATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIFLORASONE DIACETATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CLOCORTOLONE PIVALATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PREDNISOLONE ACETATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIAMCINOLONE ACETONIDE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ANDROSTENEDIONE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9384522


    Sources:
    DTC NCI

  • HYDROCORTISONE VALERATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CYPROTERONE ACETATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOBETASOL PROPIONATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROCORTISONE SODIUM SUCCINATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROCORTISONE BUTYRATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glucocorticoid receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BECLOMETHASONE DIPROPIONATE   NR3C1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIAMCINOLONE   NR3C1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name triamcinolone acetonide implant,I-vation

    PMIDs:
    19744340 16507850 15976447


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TTD

  • HYDROCORTISONE   NR3C1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    16891588 16895953 16980198 17038445 17086345 16759088 15634032


    Sources:
    DTC ChemblInteractions TTD

  • CLOBETASOL   NR3C1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name clobetasol propionate,Olux Foam

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PREDNISOLONE   NR3C1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes
    Trial Name CRx-102, prednisolone plus dipyridamole ,Synavive

    PMIDs:
    2879901 19482847


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • POTASSIUM DICHROMATE   NR3C1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIBUTYLDICHLOROSTANNANE   NR3C1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MOMETASONE FUROATE   NR3C1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glucocorticoid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TESTOSTERONE PROPIONATE   NR3C1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENACYL CHLORIDE   NR3C1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHYLTESTOSTERONE   NR3C1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STANOLONE   NR3C1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BECLOMETHASONE   NR3C1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name beclometasone, CHF-1514, /
    Novel drug target Established target
    Trial Name beclomethasone dipropionate, BDP HFA,Qvar, Qnaze

    PMIDs:
    None found


    Sources:
    DTC TdgClinicalTrial

  • E-GUGGULSTERONE   NR3C1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEXAMETHASONE   NR3C1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name dexamethasone intravitreal implant,Ozurdex, Posurdex
    Novel drug target Established target
    Trial Name EGP-437

    PMIDs:
    16971495 16956592 16891588 16963802 16835395 11752352 20308375 23276449


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • CHRYSIN   NR3C1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19592245


    Sources:
    DTC

  • PHENOLPHTHALEIN   NR3C1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 3R14S-OCHRATOXIN A   NR3C1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTRADIOL   NR3C1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12553866


    Sources:
    DTC NCI

  • BENZO(K)FLUORANTHENE   NR3C1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETHINYL ESTRADIOL   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPYLPYRAZOLETRIOL   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • T091317   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KEPONE   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BAICALEIN   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19592245


    Sources:
    DTC

  • ZEARALENONE   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PENTABROMOPHENOL   NR3C1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOHEXIMIDE   NR3C1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL184450   NR3C1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTINOMYCIN   NR3C1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROGESTERONE   NR3C1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    14617569 2214763 18060946


    Sources:
    DTC

  • DIGITOXIN   NR3C1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLIOQUINOL   NR3C1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENYLMERCURIC ACETATE   NR3C1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CATECHOL   NR3C1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RALOXIFENE HYDROCHLORIDE   NR3C1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   NR3C1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW7647   NR3C1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZACITIDINE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIGOXIN   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CARBAMAZEPINE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHOTREXATE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12210990


    Sources:
    NCI

  • Ensembl: ENSG00000113580

    • Version: 101_38

    Alternate Names:
    NR3C1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P04150

    • Version: 01-August-2011

    Alternate Names:
    GCR_HUMAN Uniprot Id
    NR3C1 Gene Symbol
    ENSG00000113580 Ensembl Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • RussLampel: ENSG00000113580

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000113580 Ensembl Gene Id
    GLUCOCORTICOID RECEPTOR (GR). [SOURCE:UNIPROT/SWISSPROT;ACC:P04150] Description
    NR3C1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P04150

    • Version: January-2014

    Alternate Names:
    NR3C1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • BaderLabGenes: NR3C1

    • Version: February-2014

    Alternate Names:
    2908 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR3C1
    Counted Citations from 1950-2000 8469

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: P04150

    • Version: 11-September-2012

    Alternate Names:
    GCR_HUMAN Uniprot Id
    ENSG00000113580 Ensembl Gene Id
    NR3C1 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TTD: Glucocorticoid receptor

    • Version: 2020.06.01

    Alternate Names:
    NR3C1 TTD Gene Abbreviation
    T40016 TTD Target ID

    Gene Info:

    Publications:
    Valdman-Grinshpoun Y et al., 2012, Barrier-restoring therapies in atopic dermatitis: current approaches and future perspectives., Dermatol Res Pract

  • NCI: NR3C1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Zhang et al., 1997, Pulmonary phospholipid saturation increases with glucocorticoid receptor mRNAs in late gestation but not due to labor in the fetal rhesus monkey., Prostaglandins Leukot. Essent. Fatty Acids
    Fernández et al., 1995, [3H]dexamethasone binding activity in liver microsomes is modulated differently by 17 alpha-alkylated androgens and testosterone in vivo., Pharmacol. Toxicol.
    Choi et al., 2006, Expression of glucocorticoid receptor mRNAs in glucocorticoid-resistant nasal polyps., Exp. Mol. Med.

  • DTC: NR3C1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother
    Nishizaki Y et al., 2009, Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay., Bioorg Med Chem Lett
    Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000113580

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000113580 Gene Symbol
    NR3C1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GRL

    • Version: chembl_23

    Alternate Names:
    GRL GENE_SYMBOL
    NR3C1 GENE_SYMBOL
    Glucocorticoid receptor UNIPROT

    Gene Info:

    Publications:

  • GO: NR3C1

    • Version: 01-February-2022

    Alternate Names:
    GRL GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: NR3C1

    • Version: 27-Jun-2013

    Alternate Names:
    2908 Gene ID
    GCCR dGene Synonym
    GCR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: NR3C1

    • Version: 01-February-2022

    Alternate Names:
    Glucocorticoid receptor Gene Name
    P04150 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21