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NR4A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NR4A1 3164 Druggable Genome

    Alternate Names:

    3164
    NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1
    NR4A1
    GFRP1
    HMR
    N10
    NAK-1
    NGFIB
    NP10
    NUR77
    TR3
    139139
    7980
    ENSG00000123358
    OTTHUMG00000150393
    P22736
    NR4A1_HUMAN
    ORPHAN NUCLEAR RECEPTOR NR4A1 (ORPHAN NUCLEAR RECEPTOR HMR) (EARLY RESPONSE PROTEIN NAK1) (TR3 ORPHAN RECEPTOR) (ST-59). [SOURCE:UNIPROT/SWISSPROT;ACC:P22736]
    NAK1

    Gene Info:

    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000536
    Interpro Type Domain
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Evidence 1: Evidence at protein level
    Initial Gene Query NR4A1
    Counted Citations from 1950-2000 627
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    KINASE
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    St-Hilaire et al., 2006, Impaired behavioural and molecular adaptations to dopamine denervation and repeated L-DOPA treatment in Nur77-knockout mice., Eur. J. Neurosci.
    St-Hilaire et al., 2005, Denervation and repeated L-DOPA induce complex regulatory changes in neurochemical phenotypes of striatal neurons: implication of a dopamine D1-dependent mechanism., Neurobiol. Dis.
    Ichino et al., 2002, Increase of transcriptional levels of egr-1 and nur77 genes due to both nicotine treatment and withdrawal in pheochromocytoma cells., J Neural Transm (Vienna)
    Chen et al., 2002, Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells., Int. J. Cancer
    Yoo et al., 2004, Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha., J. Biol. Chem.
    Gilbert et al., 2006, Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover., Biol. Psychiatry
    Matuszyk et al., 1998, Thymic lymphomas are resistant to Nur77-mediated apoptosis., Biochem. Biophys. Res. Commun.
    Kochel et al., 2005, Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004., Biochem. Biophys. Res. Commun.
    Werme et al., 2000, NGFI-B and nor1 mRNAs are upregulated in brain reward pathways by drugs of abuse: different effects in Fischer and Lewis rats., Brain Res. Mol. Brain Res.
    Zhan Y et al., 2008, Cytosporone B is an agonist for nuclear orphan receptor Nur77., Nat Chem Biol
    McLaughlin et al., 1996, The role of oxygen in thymocyte apoptosis., Eur. J. Immunol.
    Liu et al., 2002, Induction of apoptosis by TPA and VP-16 is through translocation of TR3., World J. Gastroenterol.
  • CYTOSPORONE B   NR4A1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18690216


    Sources:
    DTC

  • IONOMYCIN   NR4A1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9705872 16051191


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   NR4A1

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12046067


    Sources:
    NCI

  • ACETYLCYSTEINE   NR4A1

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8647183


    Sources:
    NCI

  • CHEMBL547833   NR4A1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEVODOPA   NR4A1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16930409 15896973


    Sources:
    NCI

  • MORPHINE   NR4A1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10719211


    Sources:
    NCI

  • NICOTINE   NR4A1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12111438 11979430


    Sources:
    NCI

  • CHEMBL35482   NR4A1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15385570


    Sources:
    NCI

  • HALOPERIDOL   NR4A1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16893530


    Sources:
    NCI

  • Ensembl: ENSG00000123358

    • Version: 101_38

    Alternate Names:
    NR4A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000123358

    • Version: 26-July-2011

    Alternate Names:
    ORPHAN NUCLEAR RECEPTOR NR4A1 (ORPHAN NUCLEAR RECEPTOR HMR) (EARLY RESPONSE PROTEIN NAK1) (TR3 ORPHAN RECEPTOR) (ST-59). [SOURCE:UNIPROT/SWISSPROT;ACC:P22736] Description
    NR4A1 Display Id
    ENSG00000123358 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: NR4A1

    • Version: February-2014

    Alternate Names:
    3164 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR4A1
    Counted Citations from 1950-2000 627

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: P22736

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000123358 Ensembl Gene Id
    NR4A1 Uniprot Gene Name
    NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1 Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000536
    Interpro Type Domain

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • NCI: NR4A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ichino et al., 2002, Increase of transcriptional levels of egr-1 and nur77 genes due to both nicotine treatment and withdrawal in pheochromocytoma cells., J Neural Transm (Vienna)
    Chen et al., 2002, Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells., Int. J. Cancer
    Joshi-Barve et al., 1993, Interleukin-1-inducible expression of gro-beta via NF-kappa B activation is dependent upon tyrosine kinase signaling., J. Biol. Chem.

  • DTC: NR4A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Zhan Y et al., 2008, Cytosporone B is an agonist for nuclear orphan receptor Nur77., Nat Chem Biol

  • HingoraniCasas: ENSG00000123358

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000123358 Gene Symbol
    NR4A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: NR4A1

    • Version: 01-February-2022

    Alternate Names:
    GFRP1 GO Gene Synonym
    HMR GO Gene Synonym
    NAK1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: NR4A1

    • Version: 27-Jun-2013

    Alternate Names:
    3164 Gene ID
    GFRP1 dGene Synonym
    HMR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: NR4A1

    • Version: 01-February-2022

    Alternate Names:
    Nuclear receptor subfamily 4 group A member 1 Gene Name
    P22736 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21