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NT5E Gene Record

  • Summary
  • Interactions
  • Claims
  • NT5E 4907 Druggable Genome

    Alternate Names:

    4907
    5'-NUCLEOTIDASE ECTO
    NT5E
    CALJA
    CD73
    E5NT
    NT
    NT5
    NTE
    eN
    eNT
    129190
    8021
    ENSG00000135318
    OTTHUMG00000015139
    3976
    P21589
    Ecto-5'-Nucleotidase
    T65116

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Hauschildt et al., 1988, Role of inositol starvation on ecto-5'-nucleotidase activity during mitogen-induced lymphocyte activation., Immunol. Lett.
    Ozüyaman et al., 2006, Adenosine produced via the CD73/ecto-5'-nucleotidase pathway has no impact on erythropoietin production but is associated with reduced kidney weight., Pflugers Arch.
    Cushman et al., 2015, Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)., Clin. Cancer Res.
    Ujházy et al., 1994, Ecto-5'-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin., Int. J. Cancer
    Tsukamoto et al., 2005, A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart., Biochem. Biophys. Res. Commun.
    Ledoux et al., 2002, Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases., Circ. Res.
    Morabito et al., 1998, Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides., J. Clin. Invest.
    Obata et al., 2000, Reserpine attenuates interstitial adenosine-mediated activation of ecto-5'-nucleotidase in rat hearts in vivo., Arch. Biochem. Biophys.
    Sweeney et al., 1989, Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord., J. Pharmacol. Exp. Ther.
    Tasca et al., 2003, Effects of metronidazole and tinidazole on NTPDase1 and ecto-5'-nucleotidase from intact cells of Trichomonas vaginalis., FEMS Microbiol. Lett.
    Lara et al., 2001, Chronic treatment with clozapine, but not haloperidol, increases striatal ecto-5'-nucleotidase activity in rats., Neuropsychobiology
    Kitakaze et al., 1997, Vesnarinone limits infarct size via adenosine-dependent mechanisms in the canine heart., Circulation
  • TINIDAZOLE   NT5E

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14553936


    Sources:
    NCI

  • OLECLUMAB   NT5E

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VESNARINONE   NT5E

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9133521


    Sources:
    NCI

  • DIAZOXIDE   NT5E

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16271703


    Sources:
    NCI

  • EPOETIN BETA   NT5E

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16468051


    Sources:
    NCI

  • INOSITOL   NT5E

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2847980


    Sources:
    NCI

  • CAPSAICIN   NT5E

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2492344


    Sources:
    NCI

  • SULFASALAZINE   NT5E

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9435300


    Sources:
    NCI

  • RESERPINE   NT5E

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10700389


    Sources:
    NCI

  • LOVASTATIN   NT5E

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11884371


    Sources:
    NCI

  • CETUXIMAB   NT5E

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25520391


    Sources:
    CIViC

  • CLOZAPINE   NT5E

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11490180


    Sources:
    NCI

  • HALOPERIDOL   NT5E

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11490180


    Sources:
    NCI

  • DOXORUBICIN   NT5E

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7927909


    Sources:
    NCI

  • Ensembl: ENSG00000135318

    • Version: 101_38

    Alternate Names:
    NT5E Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: NT5E

    • Version: 14-September-2020

    Alternate Names:
    4907 Entrez Gene ID
    3976 CIViC Gene ID

    Gene Info:

    Publications:
    Cushman et al., 2015, Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)., Clin. Cancer Res.

  • NCI: NT5E

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Hauschildt et al., 1988, Role of inositol starvation on ecto-5'-nucleotidase activity during mitogen-induced lymphocyte activation., Immunol. Lett.
    Tasca et al., 2003, Effects of metronidazole and tinidazole on NTPDase1 and ecto-5'-nucleotidase from intact cells of Trichomonas vaginalis., FEMS Microbiol. Lett.
    Soares et al., 2004, Anticonvulsant effect of GMP depends on its conversion to guanosine., Brain Res.

  • HingoraniCasas: ENSG00000135318

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135318 Gene Symbol
    NT5E Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: NT5E

    • Version: 19.3

    Alternate Names:
    ENSG00000135318 Ensembl Gene ID
    CALJA Human Protein Atlas Gene Synonym
    CD73 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, ENZYME

    Publications:

  • GO: NT5E

    • Version: 01-February-2022

    Alternate Names:
    NT5 GO Gene Synonym
    NTE GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Ecto-5'-nucleotidase

    • Version: 2020.06.01

    Alternate Names:
    CD73 TTD Gene Abbreviation
    T65116 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21