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NTRK1 Gene Record

  • Summary
  • Interactions
  • Claims
  • NTRK1 4914 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    4914
    NEUROTROPHIC RECEPTOR TYROSINE KINASE 1
    NTRK1
    MTC
    TRK
    TRK1
    TRKA
    Trk-A
    p140-TrkA
    191315
    8031
    ENSG00000198400
    OTTHUMG00000041304
    P04629
    Tyrosine kinase receptor
    High affinity nerve growth factor receptor
    gp140trk
    Tyrosine kinase receptor A
    Neurotrophic tyrosine kinase receptor type 1
    TRK1-transforming tyrosine kinase protein
    Tropomyosin-related kinase A
    NTRK1_HUMAN
    3983
    HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629]
    PA31817
    T07173

    Gene Info:

    Target Subclass Kinase
    Transmembrane Helix Count 1
    Target Main Class Receptors
    Target Class Receptors
    Target Subclass EC:2.7.10.1
    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query TRKA
    Counted Citations from 1950-2000 2566
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Acc IPR001245
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Human Readable Name KINASE
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (20 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    KINASE
    TYROSINE KINASE
    DRUG RESISTANCE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Vaishnavi et al., 2013, Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer., Nat. Med.
    Delbaldo, [Pharmacokinetic-pharmacodynamics relationships of imatinib (Glivec)]., Therapie
    de Groot et al., 2007, A phase II trial of imatinib therapy for metastatic medullary thyroid carcinoma., J. Clin. Endocrinol. Metab.
    Catani et al., [New orientations in the management of advanced, metastatic gastrointestinal stromal tumors (GIST): combination of surgery and systemic therapy with imatinib in a case of primary gastric location]., Chir Ital
    de Groot et al., 2006, Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations., Surgery
    Kovács et al., 2005, [Gastrointestinal stromal tumors (GISTs): clinical and pathological features]., Orv Hetil
    Yoon et al., 2003, Upregulation of TrkA neurotrophin receptor expression in the thymic subcapsular, paraseptal, perivascular, and cortical epithelial cells during thymus regeneration., Histochem. Cell Biol.
    Messier et al., 1995, High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells., Pharmacol. Toxicol.
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem
    Russo et al., 2016, Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer., Cancer Discov
    Drilon et al., 2017, Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)., Cancer Discov
    Farago et al., 2015, Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer., J Thorac Oncol
    Liu D et al., 2018, Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of <i>NTRK</i>, <i>ROS1</i>, and <i>ALK</i> fusion-positive solid tumors., Ther Clin Risk Manag
    Rolfo C et al., 2015, Entrectinib: a potent new TRK, ROS1, and ALK inhibitor., Expert Opin Investig Drugs
    Pacenta HL et al., 2018, Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma., Drug Des Devel Ther
    Ardini et al., 2016, Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications., Mol. Cancer Ther.
    Ulrich et al., 1998, Specific TrkA survival signals interfere with different apoptotic pathways., Oncogene
    Nusser et al., 2002, Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells., J. Biol. Chem.
    Meerovitch K et al., 2013, Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye., Clin Ophthalmol
    Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
    Lustig et al., 1994, An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells., Mol. Cell. Neurosci.
    Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des
    Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics
    Roskoden et al., 1999, Modulation of mRNA expression of the neurotrophins of the nerve-growth-factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment. II. Effects on p75 and trk receptor expression., Exp Brain Res
    Chattopadhyay et al., 2003, Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals., Eur. J. Neurosci.
    Kamata et al., 2005, Redox regulation of nerve growth factor-induced neuronal differentiation of PC12 cells through modulation of the nerve growth factor receptor, TrkA., Arch. Biochem. Biophys.
    Saporito et al., 1994, Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor., Mol. Pharmacol.
    Laetsch TW et al., 2018, Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study., Lancet Oncol
    Drilon A et al., 2018, Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children., N Engl J Med
    O'Reilly EM et al., 2019, Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion., Ann Oncol
    Ronsley R et al., 2018, Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma., Cold Spring Harb Mol Case Stud
    DuBois SG et al., 2018, The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas., Cancer
    Peters et al., 1993, Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism., Int. J. Cancer
    Chiarenza et al., 2001, Tamoxifen inhibits nerve growth factor-induced proliferation of the human breast cancerous cell line MCF-7., Cancer Res.
    Schmidt et al., 2000, Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia., Brain Res.
    Gill et al., 1998, Activation of the high affinity nerve growth factor receptor by two polyanionic chemotherapeutic agents: role in drug induced neurotoxicity., J. Neurooncol.
    Sano et al., 1999, Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo., J. Neurochem.
    French et al., 1999, Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine., Brain Res. Mol. Brain Res.
  • TAVILERMIDE   NTRK1

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name MIM-D3

    PMIDs:
    23836957


    Sources:
    TdgClinicalTrial TTD

  • LAROTRECTINIB   NTRK1

    Interaction Score: 3.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor
    Direct Interaction yes

    PMIDs:
    29606586 29466156 24162815 31605106 29610391 30204247


    Sources:
    ChemblInteractions CIViC TTD OncoKB

  • PEGCANTRATINIB   NTRK1

    Interaction Score: 2.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • APAZIQUONE   NTRK1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8509220


    Sources:
    NCI

  • SELITRECTINIB   NTRK1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RADICICOL   NTRK1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10349833


    Sources:
    NCI

  • PYRIDOXINE   NTRK1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12603263


    Sources:
    NCI

  • LESTAURTINIB   NTRK1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name lestaurtinib , CEP-701
    Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

    PMIDs:
    24162815


    Sources:
    TdgClinicalTrial ChemblInteractions CIViC

  • PRASUGREL   NTRK1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28820077 23859572


    Sources:
    PharmGKB

  • AZD-7451   NTRK1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GAMBOGIC AMIDE   NTRK1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • AZD-6918   NTRK1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GW632580X   NTRK1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALTIRATINIB   NTRK1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PLX-7486   NTRK1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MILCICLIB   NTRK1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GAMBOGIC ACID   NTRK1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • ENTRECTINIB   NTRK1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26546295 28183697 26565381 30050303 26457764 30425456 26939704


    Sources:
    DTC CIViC PharmGKB OncoKB

  • THYROXINE   NTRK1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10452218


    Sources:
    NCI

  • PILOCARPINE   NTRK1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10101239


    Sources:
    NCI

  • BMS-754807   NTRK1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19778024


    Sources:
    DTC

  • PHENYLEPHRINE   NTRK1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7567780


    Sources:
    NCI

  • ACETYLCYSTEINE   NTRK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15629104


    Sources:
    NCI

  • CRIZOTINIB   NTRK1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24162815


    Sources:
    CIViC

  • IMATINIB   NTRK1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name imatinib mesylate, STI 571,Gleevec, Glivec

    PMIDs:
    17582306 17579194 15832750 16782438 16052979


    Sources:
    TdgClinicalTrial TEND

  • WORTMANNIN   NTRK1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9484773 12133829


    Sources:
    NCI

  • ANDROSTANOLONE   NTRK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7704433


    Sources:
    NCI

  • SURAMIN   NTRK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9874182


    Sources:
    NCI

  • CEP-2563   NTRK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • STREPTOZOCIN   NTRK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10837808


    Sources:
    NCI

  • ASPIRIN   NTRK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28820077 23859572


    Sources:
    PharmGKB

  • ENMD-2076   NTRK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name ENMD-2076

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • REGORAFENIB   NTRK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenomeClinicalTrial

  • TAMOXIFEN   NTRK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11306479


    Sources:
    NCI

  • CHEMBL546797   NTRK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AST-487   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW843682X   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOPHOSPHAMIDE   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12548406


    Sources:
    NCI

  • HESPERADIN   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • DEXAMETHASONE   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8145726


    Sources:
    NCI

  • ALISERTIB   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC ClearityFoundationClinicalTrial

  • PD-0166285   NTRK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METHOTREXATE   NTRK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8509220


    Sources:
    NCI

  • GW441756X   NTRK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOZASERTIB   NTRK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SORAFENIB   NTRK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   NTRK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   NTRK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   NTRK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   NTRK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000198400

    • Version: 101_38

    Alternate Names:
    NTRK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: NTRK1

    • Version: February-2014

    Alternate Names:
    4914 Entrez Gene ID

    Gene Info:
    Initial Gene Query TRKA
    Counted Citations from 1950-2000 2566

    Gene Categories:
    KINASE

    Publications:

  • TEND: P04629

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000198400 Ensembl Gene Id
    4914 Entrez Gene Id
    P04629 Uniprot Accession

    Gene Info:
    Target Subclass Kinase
    Transmembrane Helix Count 1
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: P04629

    • Version: January-2014

    Alternate Names:
    NTRK1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:2.7.10.1

    Publications:

  • HopkinsGroom: P04629

    • Version: 11-September-2012

    Alternate Names:
    P04629 Uniprot Accession
    ENSG00000198400 Ensembl Gene Id
    NTRK1_HUMAN Uniprot Id

    Gene Info:
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Acc IPR001245
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000198400

    • Version: 26-July-2011

    Alternate Names:
    NTRK1 Display Id
    HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629] Description
    ENSG00000198400 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: NTRK1

    • Version: 18-August-2020

    Alternate Names:
    PA31817 PharmGKB ID

    Gene Info:

    Publications:
    Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des
    Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics

  • CIViC: NTRK1

    • Version: 14-September-2020

    Alternate Names:
    4914 Entrez Gene ID
    3983 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    DuBois SG et al., 2018, The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas., Cancer
    Laetsch TW et al., 2018, Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study., Lancet Oncol
    Drilon A et al., 2018, Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children., N Engl J Med

  • TTD: Tropomyosin-related kinase A

    • Version: 2020.06.01

    Alternate Names:
    TrkA TTD Gene Abbreviation
    T07173 TTD Target ID

    Gene Info:

    Publications:
    Meerovitch K et al., 2013, Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye., Clin Ophthalmol

  • NCI: NTRK1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lustig et al., 1994, An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells., Mol. Cell. Neurosci.
    Chattopadhyay et al., 2003, Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals., Eur. J. Neurosci.
    Sano et al., 1999, Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo., J. Neurochem.

  • DTC: NTRK1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A

  • HingoraniCasas: ENSG00000198400

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198400 Gene Symbol
    NTRK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: MTC

    • Version: chembl_23

    Alternate Names:
    TRK GENE_SYMBOL
    TRKA GENE_SYMBOL
    NTRK1 GENE_SYMBOL

    Gene Info:

    Publications:

  • OncoKB: NTRK1

    • Version: 23-July-2020

    Alternate Names:
    4914 OncoKB Entrez Id
    TRK1 OncoKB Gene Synonym
    TRKA OncoKB Gene Synonym

    Gene Info:

    Publications:

  • GO: NTRK1

    • Version: 01-February-2022

    Alternate Names:
    MTC GO Gene Synonym
    TRK GO Gene Synonym
    TRKA GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TYROSINE KINASE

    Publications:

  • Tempus: NTRK1

    • Version: 11-November-2018

    Alternate Names:
    NTRK1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: NTRK1

    • Version: 27-Jun-2013

    Alternate Names:
    4914 Gene ID
    MTC dGene Synonym
    TRK dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • Pharos: NTRK1

    • Version: 01-February-2022

    Alternate Names:
    High affinity nerve growth factor receptor Gene Name
    P04629 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • ClearityFoundationClinicalTrial: NTRK1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MyCancerGenomeClinicalTrial: NTRK1

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: NTRK1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: NTRK1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: NTRK1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: NTRK1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21