DGIdb - NTRK1 Gene Record

NTRK1 4914 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

4914
NEUROTROPHIC RECEPTOR TYROSINE KINASE 1
NTRK1
MTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
191315
8031
ENSG00000198400
OTTHUMG00000041304
BE0001039
P04629
Tyrosine kinase receptor
High affinity nerve growth factor receptor
gp140trk
Tyrosine kinase receptor A
Neurotrophic tyrosine kinase receptor type 1
TRK1-transforming tyrosine kinase protein
Tropomyosin-related kinase A
NTRK1_HUMAN
3983
1817
NP_001007793
NM_001007792
HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629]
PA31817
T07173

Gene Info:

Target Subclass	Kinase
Transmembrane Helix Count	1
Target Main Class	Receptors
Target Class	Receptors
Target Subclass	EC:2.7.10.1
GuideToPharmacology Gene Category Name	Type VII RTKs: Neurotrophin receptor/Trk family
GuideToPharmacology Gene Category ID	326
Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	TRKA
Counted Citations from 1950-2000	2566
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Acc	IPR001245
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Human Readable Name	KINASE
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(23 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
TYROSINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Vaishnavi et al., 2013, Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer., Nat. Med.
de Groot et al., 2006, Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations., Surgery
de Groot et al., 2007, A phase II trial of imatinib therapy for metastatic medullary thyroid carcinoma., J. Clin. Endocrinol. Metab.
Delbaldo, [Pharmacokinetic-pharmacodynamics relationships of imatinib (Glivec)]., Therapie
Catani et al., [New orientations in the management of advanced, metastatic gastrointestinal stromal tumors (GIST): combination of surgery and systemic therapy with imatinib in a case of primary gastric location]., Chir Ital
Kovács et al., 2005, [Gastrointestinal stromal tumors (GISTs): clinical and pathological features]., Orv Hetil
Yoon et al., 2003, Upregulation of TrkA neurotrophin receptor expression in the thymic subcapsular, paraseptal, perivascular, and cortical epithelial cells during thymus regeneration., Histochem. Cell Biol.
Messier et al., 1995, High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells., Pharmacol. Toxicol.
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem
Ardini et al., 2016, Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications., Mol. Cancer Ther.
Pacenta HL et al., 2018, Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma., Drug Des Devel Ther
Russo et al., 2016, Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer., Cancer Discov
Liu D et al., 2018, Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of <i>NTRK</i>, <i>ROS1</i>, and <i>ALK</i> fusion-positive solid tumors., Ther Clin Risk Manag
Rolfo C et al., 2015, Entrectinib: a potent new TRK, ROS1, and ALK inhibitor., Expert Opin Investig Drugs
Farago et al., 2015, Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer., J Thorac Oncol
Drilon et al., 2017, Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)., Cancer Discov
Nusser et al., 2002, Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells., J. Biol. Chem.
Ulrich et al., 1998, Specific TrkA survival signals interfere with different apoptotic pathways., Oncogene
Meerovitch K et al., 2013, Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye., Clin Ophthalmol
Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
Lustig et al., 1994, An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells., Mol. Cell. Neurosci.
Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des
Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics
Rantamäki T et al., 2011, Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade., PLoS One
Jang et al., 2009, Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity., Chem. Biol.
Zheng X et al., 2016, Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons., Medicine (Baltimore)
Roskoden et al., 1999, Modulation of mRNA expression of the neurotrophins of the nerve-growth-factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment. II. Effects on p75 and trk receptor expression., Exp Brain Res
Chattopadhyay et al., 2003, Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals., Eur. J. Neurosci.
Kamata et al., 2005, Redox regulation of nerve growth factor-induced neuronal differentiation of PC12 cells through modulation of the nerve growth factor receptor, TrkA., Arch. Biochem. Biophys.
Saporito et al., 1994, Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor., Mol. Pharmacol.
DuBois SG et al., 2018, The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas., Cancer
Laetsch TW et al., 2018, Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study., Lancet Oncol
Drilon A et al., 2018, Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children., N Engl J Med
Ronsley R et al., 2018, Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma., Cold Spring Harb Mol Case Stud
O'Reilly EM et al., 2019, Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion., Ann Oncol
Peters et al., 1993, Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism., Int. J. Cancer
Chiarenza et al., 2001, Tamoxifen inhibits nerve growth factor-induced proliferation of the human breast cancerous cell line MCF-7., Cancer Res.
Schmidt et al., 2000, Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia., Brain Res.
Gill et al., 1998, Activation of the high affinity nerve growth factor receptor by two polyanionic chemotherapeutic agents: role in drug induced neurotoxicity., J. Neurooncol.
Sano et al., 1999, Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo., J. Neurochem.
French et al., 1999, Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine., Brain Res. Mol. Brain Res.
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

LAROTRECTINIB NTRK1

Interaction Score: 2.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

Details of the Assay for Interaction Measured using a TrkA ELISA.

PMIDs:
30204247 29606586 29466156 24162815 29610391 31605106

Sources:
OncoKB CIViC TTD DrugBank GuideToPharmacology ChemblInteractions
TAVILERMIDE NTRK1

Interaction Score: 2.84

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name MIM-D3

PMIDs:
23836957

Sources:
TdgClinicalTrial TTD
PEGCANTRATINIB NTRK1

Interaction Score: 1.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
APAZIQUONE NTRK1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8509220

Sources:
NCI
SELITRECTINIB NTRK1

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
CENEGERMIN NTRK1

Interaction Score: 0.47

Interaction Types & Directionality:

stimulator (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
PYRIDOXINE NTRK1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12603263

Sources:
NCI
LESTAURTINIB NTRK1

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name lestaurtinib , CEP-701

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

PMIDs:
24162815

Sources:
TdgClinicalTrial CIViC ChemblInteractions
PRASUGREL NTRK1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28820077 23859572

Sources:
PharmGKB
AZD-7451 NTRK1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RADICICOL NTRK1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10349833

Sources:
NCI
GAMBOGIC AMIDE NTRK1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17911251

Sources:
DTC
AZD-6918 NTRK1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MILCICLIB NTRK1

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
GW632580X NTRK1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALTIRATINIB NTRK1

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
PLX-7486 NTRK1

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
GAMBOGIC ACID NTRK1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17911251

Sources:
DTC
ENTRECTINIB NTRK1

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26939704 30425456 26546295 30050303 26457764 26565381 28183697

Sources:
DTC OncoKB PharmGKB CIViC DrugBank
CHEMBL1908395 NTRK1

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
REPOTRECTINIB NTRK1

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Details of Interaction IC<sub>50</sub> for TRKA<sup>G595R</sup> is 2.7 nM

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
THYROXINE NTRK1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10452218

Sources:
NCI
BMS-754807 NTRK1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
CRIZOTINIB NTRK1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family ALK inhibitor

Alteration NTRK1__.

PMIDs:
24162815

Sources:
CIViC CGI
PILOCARPINE NTRK1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10101239

Sources:
NCI
PHENYLEPHRINE NTRK1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7567780

Sources:
NCI
IMATINIB NTRK1

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name imatinib mesylate, STI 571,Gleevec, Glivec

PMIDs:
16782438 17579194 17582306 15832750 16052979

Sources:
TEND TdgClinicalTrial DrugBank
GILTERITINIB NTRK1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
AMITRIPTYLINE NTRK1

Interaction Score: 0.09

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

PMIDs:
21666748 19549602 27149473

Sources:
DrugBank
ANDROSTANOLONE NTRK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7704433

Sources:
NCI
WORTMANNIN NTRK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12133829 9484773

Sources:
NCI
ACETYLCYSTEINE NTRK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15629104

Sources:
NCI
SITRAVATINIB NTRK1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical enzyme activity assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MK-2461 NTRK1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
REGORAFENIB NTRK1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial DrugBank
CEP-2563 NTRK1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEP-11981 NTRK1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
SURAMIN NTRK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9874182

Sources:
NCI
STREPTOZOCIN NTRK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10837808

Sources:
NCI
ENMD-2076 NTRK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial
ASPIRIN NTRK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28820077 23859572

Sources:
PharmGKB
CHEMBL546797 NTRK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAMOXIFEN NTRK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11306479

Sources:
NCI
AST-487 NTRK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOPHOSPHAMIDE NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12548406

Sources:
NCI
HESPERADIN NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
ALISERTIB NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXAMETHASONE NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8145726

Sources:
NCI
DOVITINIB NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial DTC
PD-0166285 NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHOTREXATE NTRK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8509220

Sources:
NCI
GW441756X NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB NTRK1

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000198400
- Version: 101_38
Alternate Names:

NTRK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: NTRK1
- Version: February-2014
Alternate Names:

4914 Entrez Gene ID

Gene Info:

Initial Gene Query TRKA

Counted Citations from 1950-2000 2566

Gene Categories:

KINASE

Publications:
TEND: P04629
- Version: 01-August-2011
Alternate Names:

ENSG00000198400 Ensembl Gene Id

4914 Entrez Gene Id

P04629 Uniprot Accession

Gene Info:

Target Subclass Kinase

Transmembrane Helix Count 1

Target Main Class Receptors

Publications:
TdgClinicalTrial: P04629
- Version: January-2014
Alternate Names:

NTRK1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
HopkinsGroom: P04629
- Version: 11-September-2012
Alternate Names:

P04629 Uniprot Accession

ENSG00000198400 Ensembl Gene Id

NTRK1_HUMAN Uniprot Id

Gene Info:

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Interpro Acc IPR001245

Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000198400

Version: 26-July-2011

Alternate Names:

NTRK1 Display Id

HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629] Description

ENSG00000198400 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 4914
- Version: 29-September-2020
Alternate Names:

8031 HUGO Gene ID

8031 HUGO Gene Symbol

neurotrophic receptor tyrosine kinase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Type VII RTKs: Neurotrophin receptor/Trk family

GuideToPharmacology Gene Category ID 326

Publications:

PharmGKB: NTRK1

Version: 18-August-2020

Alternate Names:

PA31817 PharmGKB ID

Gene Info:

Publications:

Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des

Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics

CIViC: NTRK1

Version: 14-September-2020

Alternate Names:

4914 Entrez Gene ID

3983 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

DuBois SG et al., 2018, The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas., Cancer

Laetsch TW et al., 2018, Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study., Lancet Oncol

Drilon A et al., 2018, Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children., N Engl J Med

DrugBank: BE0001039

Version: 5.1.7

Alternate Names:

NTRK1 DrugBank Gene Name

P04629 UniProt Accession

4914 Entrez Gene Id

Gene Info:

Publications:

Rantamäki T et al., 2011, Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade., PLoS One

Jang et al., 2009, Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity., Chem. Biol.

Zheng X et al., 2016, Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons., Medicine (Baltimore)

TTD: Tropomyosin-related kinase A
- Version: 2020.06.01
Alternate Names:

TrkA TTD Gene Abbreviation

T07173 TTD Target ID

Gene Info:

Publications:

Meerovitch K et al., 2013, Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye., Clin Ophthalmol

NCI: NTRK1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lustig et al., 1994, An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells., Mol. Cell. Neurosci.

Chattopadhyay et al., 2003, Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals., Eur. J. Neurosci.

Sano et al., 1999, Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo., J. Neurochem.

DTC: NTRK1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A

HingoraniCasas: ENSG00000198400
- Version: 31-May-2017
Alternate Names:

ENSG00000198400 Gene Symbol

NTRK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: MTC
- Version: chembl_23
Alternate Names:

TRK GENE_SYMBOL

TRKA GENE_SYMBOL

NTRK1 GENE_SYMBOL

Gene Info:

Publications:
OncoKB: NTRK1
- Version: 23-July-2020
Alternate Names:

4914 OncoKB Entrez Id

TRK1 OncoKB Gene Synonym

TRKA OncoKB Gene Synonym

Gene Info:

Publications:
Pharos: NTRK1
- Version: 03-September-2020
Alternate Names:

High affinity nerve growth factor receptor Gene Name

P04629 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: NTRK1
- Version: 05-September-2020
Alternate Names:

MTC GO Gene Synonym

TRK GO Gene Synonym

TRKA GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, TYROSINE KINASE, DRUG RESISTANCE

Publications:
Tempus: NTRK1
- Version: 11-November-2018
Alternate Names:

NTRK1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: NTRK1
- Version: 27-Jun-2013
Alternate Names:

4914 Gene ID

MTC dGene Synonym

TRK dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
ClearityFoundationClinicalTrial: NTRK1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: NTRK1
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
CGI: NTRK1
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:
MskImpact: NTRK1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: NTRK1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: NTRK1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: NTRK1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Neurotrophic tyrosine kinase receptor inhibitor
Direct Interaction	yes
Details of the Assay for Interaction	Measured using a TrkA ELISA.

Mechanism of Interaction	Nerve growth factor receptor Trk-A inhibitor
Direct Interaction	yes

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Novel drug target	Established target
Trial Name	lestaurtinib , CEP-701
Mechanism of Interaction	Nerve growth factor receptor Trk-A inhibitor

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Details of Interaction	IC<sub>50</sub> for TRKA<sup>G595R</sup> is 2.7 nM
Endogenous Drug?	False

Details of the Assay for Interaction	In a biochemical enzyme activity assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

ENSG00000198400	Ensembl Gene Id
4914	Entrez Gene Id
P04629	Uniprot Accession

NTRK1	Display Id
HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629]	Description
ENSG00000198400	Ensembl Gene Id

8031	HUGO Gene ID
8031	HUGO Gene Symbol
neurotrophic receptor tyrosine kinase 1	HUGO Gene Name

NTRK1	DrugBank Gene Name
P04629	UniProt Accession
4914	Entrez Gene Id

4914	OncoKB Entrez Id
TRK1	OncoKB Gene Synonym
TRKA	OncoKB Gene Synonym

High affinity nerve growth factor receptor	Gene Name
P04629	UniProt ID

NTRK1 Gene Record

NTRK1 4914 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor Direct Interaction yes Details of the Assay for Interaction Measured using a TrkA ELISA.

PMIDs: 30204247 29606586 29466156 24162815 29610391 31605106

Sources: OncoKB CIViC TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name MIM-D3

PMIDs: 23836957

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor Direct Interaction yes

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8509220

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: stimulator (activating)

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12603263

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name lestaurtinib , CEP-701 Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

PMIDs: 24162815

Sources: TdgClinicalTrial CIViC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28820077 23859572

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10349833

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17911251

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17911251

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

Details of the Assay for Interaction Measured using a TrkA ELISA.

PMIDs:
30204247 29606586 29466156 24162815 29610391 31605106

Sources:
OncoKB CIViC TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name MIM-D3

PMIDs:
23836957

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
8509220

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

stimulator (activating)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12603263

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name lestaurtinib , CEP-701

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

PMIDs:
24162815

Sources:
TdgClinicalTrial CIViC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
28820077 23859572

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10349833

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17911251

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Neurotrophic tyrosine kinase receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Nerve growth factor receptor Trk-A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17911251

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26939704 30425456 26546295 30050303 26457764 26565381 28183697

Sources:
DTC OncoKB PharmGKB CIViC DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Details of Interaction IC<sub>50</sub> for TRKA<sup>G595R</sup> is 2.7 nM

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10452218

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19778024