4914 |
NEUROTROPHIC RECEPTOR TYROSINE KINASE 1 |
NTRK1 |
MTC |
TRK |
TRK1 |
TRKA |
Trk-A |
p140-TrkA |
191315 |
8031 |
ENSG00000198400 |
OTTHUMG00000041304 |
BE0001039 |
P04629 |
Tyrosine kinase receptor |
High affinity nerve growth factor receptor |
gp140trk |
Tyrosine kinase receptor A |
Neurotrophic tyrosine kinase receptor type 1 |
TRK1-transforming tyrosine kinase protein |
Tropomyosin-related kinase A |
NTRK1_HUMAN |
3983 |
1817 |
NP_001007793 |
NM_001007792 |
HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629] |
PA31817 |
T07173 |
Target Subclass | Kinase |
Transmembrane Helix Count | 1 |
Target Main Class | Receptors |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
GuideToPharmacology Gene Category Name | Type VII RTKs: Neurotrophin receptor/Trk family |
GuideToPharmacology Gene Category ID | 326 |
Human Readable Name | DRUGGABLE GENOME |
Initial Gene Query | TRKA |
Counted Citations from 1950-2000 | 2566 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Acc | IPR001245 |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
Human Readable Name | KINASE |
Uniprot Status | Swiss-Prot |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
Direct Interaction | yes |
Details of the Assay for Interaction | Measured using a TrkA ELISA. |
n/a |
Novel drug target | Established target |
Trial Name | MIM-D3 |
inhibitor (inhibitory) |
Mechanism of Interaction | Nerve growth factor receptor Trk-A inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
stimulator (activating) |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | lestaurtinib , CEP-701 |
Mechanism of Interaction | Nerve growth factor receptor Trk-A inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Nerve growth factor receptor Trk-A inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Nerve growth factor receptor Trk-A inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Details of Interaction | IC<sub>50</sub> for TRKA<sup>G595R</sup> is 2.7 nM |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Details of the Assay for Interaction | In a biochemical enzyme activity assay. |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
n/a |
Novel drug target | Established target |
Trial Name | ENMD-2076 |
n/a |
NTRK1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
4914 | Entrez Gene ID |
Initial Gene Query | TRKA |
Counted Citations from 1950-2000 | 2566 |
KINASE |
ENSG00000198400 | Ensembl Gene Id |
4914 | Entrez Gene Id |
P04629 | Uniprot Accession |
Target Subclass | Kinase |
Transmembrane Helix Count | 1 |
Target Main Class | Receptors |
NTRK1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
P04629 | Uniprot Accession |
ENSG00000198400 | Ensembl Gene Id |
NTRK1_HUMAN | Uniprot Id |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Acc | IPR001245 |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
KINASE, DRUGGABLE GENOME |
NTRK1 | Display Id |
HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1) (TRK1 TRANSFORMING TYROSINE KINASE PROTEIN) (P140-TRKA) (TRK-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P04629] | Description |
ENSG00000198400 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
8031 | HUGO Gene ID |
8031 | HUGO Gene Symbol |
neurotrophic receptor tyrosine kinase 1 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Type VII RTKs: Neurotrophin receptor/Trk family |
GuideToPharmacology Gene Category ID | 326 |
PA31817 | PharmGKB ID |
4914 | Entrez Gene ID |
3983 | CIViC Gene ID |
DRUG RESISTANCE |
NTRK1 | DrugBank Gene Name |
P04629 | UniProt Accession |
4914 | Entrez Gene Id |
TrkA | TTD Gene Abbreviation |
T07173 | TTD Target ID |
ENSG00000198400 | Gene Symbol |
NTRK1 | Ensembl Id |
DRUGGABLE GENOME |
TRK | GENE_SYMBOL |
TRKA | GENE_SYMBOL |
NTRK1 | GENE_SYMBOL |
4914 | OncoKB Entrez Id |
TRK1 | OncoKB Gene Synonym |
TRKA | OncoKB Gene Synonym |
High affinity nerve growth factor receptor | Gene Name |
P04629 | UniProt ID |
KINASE |
MTC | GO Gene Synonym |
TRK | GO Gene Synonym |
TRKA | GO Gene Synonym |
CELL SURFACE, TYROSINE KINASE, DRUG RESISTANCE |
NTRK1 | Gene Symbol |
CLINICALLY ACTIONABLE |
4914 | Gene ID |
MTC | dGene Synonym |
TRK | dGene Synonym |
KINASE, TYROSINE KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |