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NTS Gene Record

  • Summary
  • Interactions
  • Claims
  • NTS 4922 Druggable Genome

    Alternate Names:

    4922
    NEUROTENSIN
    NTS
    NMN-125
    NN
    NT
    NT/N
    NTS1
    162650
    8038
    ENSG00000133636
    OTTHUMG00000169832
    PA31820

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Rugarn et al., 2001, Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum., Regul. Pept.
    Clement et al., 1994, Effects of haloperidol, quinelorane, and lithium on regional neurotensin/neuromedin N concentrations: further evidence for neurotensin/neuromedin N-dopamine interactions., Synapse
    Golba et al., 1995, The dihydropyridines modulate neurotensin inotropic action paradoxically., J. Physiol. Pharmacol.
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
    Kinkead et al., 2000, Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain., J. Pharmacol. Exp. Ther.
    Giardino et al., 1990, DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugs., Brain Res.
    Erwin et al., 1997, Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects., J. Pharmacol. Exp. Ther.
    Duncan et al., Neurotensin modulates K(+)-stimulated dopamine release from the caudate-putamen but not the nucleus accumbens of mice with differential sensitivity to ethanol., Alcohol
    Campbell et al., 1991, Regional characterization of brain neurotensin receptor subtypes in LS and SS mice., Alcohol. Clin. Exp. Res.
    Tatsuta et al., 1991, Inhibition by neurotensin of azaserine-induced carcinogenesis in rat pancreas., Int. J. Cancer
  • AZASERINE   NTS

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1993548


    Sources:
    NCI

  • NORETHINDRONE   NTS

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11495683


    Sources:
    NCI

  • CHLORPROMAZINE   NTS

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1980851


    Sources:
    NCI

  • ALCOHOL   NTS

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9023306 1733422 1686369


    Sources:
    NCI

  • LITHIUM   NTS

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7992199


    Sources:
    NCI

  • NIFEDIPINE   NTS

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8770786


    Sources:
    NCI

  • RISPERIDONE   NTS

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10991962


    Sources:
    NCI

  • HALOPERIDOL   NTS

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023437


    Sources:
    PharmGKB

  • Ensembl: ENSG00000133636

    • Version: 101_38

    Alternate Names:
    NTS Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: NTS

    • Version: 18-August-2020

    Alternate Names:
    PA31820 PharmGKB ID

    Gene Info:

    Publications:
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

  • NCI: NTS

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Clement et al., 1994, Effects of haloperidol, quinelorane, and lithium on regional neurotensin/neuromedin N concentrations: further evidence for neurotensin/neuromedin N-dopamine interactions., Synapse
    Golba et al., 1995, The dihydropyridines modulate neurotensin inotropic action paradoxically., J. Physiol. Pharmacol.
    Eberhardt et al., 1991, [Neurotensin liberation during the consumption of mineral water from Bad Mergentheimer Karlsquelle]., Leber Magen Darm

  • HingoraniCasas: ENSG00000133636

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000133636 Gene Symbol
    NTS Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21