4986 |
OPIOID RECEPTOR KAPPA 1 |
OPRK1 |
K-OR-1 |
KOR |
KOR-1 |
OPRK |
165196 |
8154 |
ENSG00000082556 |
OTTHUMG00000164276 |
P41145 |
KAPPA-TYPE OPIOID RECEPTOR |
OPRK_HUMAN |
OPIOID RECEPTOR KAPPA |
KAPPA-TYPE OPIOID RECEPTOR (KOR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P41145] |
PA31943 |
T60693 |
KOP |
KOR1 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Target Subclass | GPCR |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Mechanism of Interaction | Kappa opioid receptor antagonist |
Direct Interaction | yes |
Trial Name | - |
agonist (activating) |
Trial Name | REN-213 |
Novel drug target | Established target |
Trial Name | nalbuphine hydrochloride, PW-4142 |
agonist (activating) |
Trial Name | CR845 |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | asimadoline |
agonist (activating) |
Mechanism of Interaction | Kappa opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
Trial Name | ALO-01, morphine sulfate and naltrexone hydrochloride,Embeda, Kadian NT |
antagonist (inhibitory) |
agonist (activating) |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Novel drug target | Established target |
Trial Name | NMED-1077,Exalgo, Jurnista, Dilaudid |
partial agonist (activating) |
antagonist (inhibitory) |
Trial Name | nalmefene, CPH-101 |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Kappa opioid receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Kappa opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
antagonist (inhibitory) |
Mechanism of Interaction | Kappa opioid receptor agonist |
Direct Interaction | yes |
Trial Name | ALKS 5461 |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Kappa opioid receptor agonist |
partial agonist (activating) |
Mechanism of Interaction | Kappa opioid receptor partial agonist |
Direct Interaction | yes |
n/a |
Trial Name | sufentanil transdermal patch,Transdur-sufentanil |
Novel drug target | Established target |
Trial Name | sufentanil,Chronogesic |
antagonist (inhibitory) |
Trial Name | buprenorphine + naloxone capsule,NanoBUP |
Novel drug target | Established target |
Trial Name | buprenorphine + naloxone,Suboxone |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
n/a |
Trial Name | KP201 (prodrug of hydrocodone) |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Kappa opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Kappa opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | PTI-601 |
Novel drug target | Established target |
Trial Name | tramadol extended-release,Raliva ER |
agonist (activating) |
n/a |
Trial Name | - |
Novel drug target | Established target |
OPRK1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000082556 | Ensembl Gene Id |
OPRK1 | Uniprot Gene Name |
P41145 | Uniprot Accession |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
P41145 | Uniprot Accession |
OPRK_HUMAN | Uniprot Id |
ENSG00000082556 | Ensembl Gene Id |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
KAPPA-TYPE OPIOID RECEPTOR (KOR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P41145] | Description |
OPRK1 | Display Id |
ENSG00000082556 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
OPRK1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
PA31943 | PharmGKB ID |
OPRK1 | TTD Gene Abbreviation |
T60693 | TTD Target ID |
ENSG00000082556 | Gene Symbol |
OPRK1 | Ensembl Id |
DRUGGABLE GENOME |
OPRK | GENE_SYMBOL |
OPRK1 | GENE_SYMBOL |
Kappa-type opioid receptor | UNIPROT |
OPRK | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
4986 | Gene ID |
KOR | dGene Synonym |
OPRK | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |