• OPRL1 4987 Druggable Genome

    Alternate Names:

    4987
    OPIOID RELATED NOCICEPTIN RECEPTOR 1
    OPRL1
    KOR-3
    NOCIR
    NOP
    NOPr
    OOR
    ORL1
    602548
    8155
    ENSG00000125510
    OTTHUMG00000033027
    NOCICEPTIN RECEPTOR (ORPHANIN FQ RECEPTOR) (KAPPA-TYPE 3 OPIOID RECEPTOR) (KOR-3). [SOURCE:UNIPROT/SWISSPROT;ACC:P41146]
    P41146
    OPRX_HUMAN
    Orphanin FQ receptor
    Kappa-type 3 opioid receptor
    Nociceptin receptor
    NOP receptor
    320
    NP_000904
    NM_000913
    PA31944
    T52921
    KOR3
    OPRL
    PNOCR

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    GuideToPharmacology Gene Category Name Opioid receptors
    GuideToPharmacology Gene Category ID 50
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Acc IPR000276
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    KINASE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME
  • Interaction Score: 14.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Nociceptin receptor antagonist
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 10.63

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    21330016


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 7.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Stimulation of GTP-&gamma;<sup>35</sup>S binding
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 7.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 3.54

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Stimulation of GTP-&gamma;<sup>35</sup>S binding
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    OPRL1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    NOCICEPTIN RECEPTOR Uniprot Protein Name
    ENSG00000125510 Ensembl Gene Id
    OPRX_HUMAN Uniprot Id

    Gene Info:
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000125510 Ensembl Gene Id
    OPRL1 Display Id
    NOCICEPTIN RECEPTOR (ORPHANIN FQ RECEPTOR) (KAPPA-TYPE 3 OPIOID RECEPTOR) (KOR-3). [SOURCE:UNIPROT/SWISSPROT;ACC:P41146] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    8155 HUGO Gene ID
    8155 HUGO Gene Symbol
    opioid related nociceptin receptor 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Opioid receptors
    GuideToPharmacology Gene Category ID 50

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000125510 Gene Symbol
    OPRL1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    ORL1 GENE_SYMBOL
    OPRL1 GENE_SYMBOL
    Nociceptin receptor UNIPROT

    Gene Info:

    Publications:

    • Version: 18-August-2020

    Alternate Names:
    PA31944 PharmGKB ID

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    4987 Gene ID
    KOR-3 dGene Synonym
    NOCIR dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    OPRL1 TTD Gene Abbreviation
    T52921 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    OOR GO Gene Synonym
    ORL1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Nociceptin receptor Gene Name
    P41146 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: