• P2RX7 5027 Druggable GenomeDrug Resistance

    Alternate Names:

    5027
    PURINERGIC RECEPTOR P2X 7
    P2RX7
    P2X7
    602566
    8537
    ENSG00000089041
    OTTHUMG00000169153
    P2X purinoceptor 7
    Purinergic receptor
    P2Z receptor
    ATP receptor
    484
    NM_002562
    Q99572
    NP_002553
    P2RX7_HUMAN
    P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2X7) (PURINERGIC RECEPTOR) (P2Z RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q99572]
    PA32866
    T63414

    Gene Info:

    GuideToPharmacology Gene Category Name P2X receptors
    GuideToPharmacology Gene Category ID 77
    Target Class Receptors
    Target Subclass TC:1.A.7.1.3
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Name P2X purinoreceptor
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name P2X_purnocptor
    Interpro Acc IPR001429
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUG RESISTANCE
    NUCLEAR HORMONE RECEPTOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

  • Interaction Score: 15.49

    Interaction Types & Directionality:
    allosteric modulator
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 negative allosteric modulator
    Direct Interaction yes
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 10.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 10.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction P2X purinoceptor 7 antagonist
    Direct Interaction yes
    Trial Name EVT-401

    PMIDs:
    None found


  • Interaction Score: 10.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction P2X purinoceptor 7 antagonist

    PMIDs:
    None found


  • Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.03

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.74

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Positive

    PMIDs:
    None found


  • Interaction Score: 0.57

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.37

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Negative

    PMIDs:
    None found


  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? True
    Specific Action of the Ligand Agonist

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    P2RX7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    P2RX7 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.7.1.3

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2X7) (PURINERGIC RECEPTOR) (P2Z RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q99572] Description
    ENSG00000089041 Ensembl Gene Id
    P2RX7 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000089041 Ensembl Gene Id
    Q99572 Uniprot Accession
    P2X PURINOCEPTOR 7 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    8537 HUGO Gene ID
    8537 HUGO Gene Symbol
    purinergic receptor P2X 7 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name P2X receptors
    GuideToPharmacology Gene Category ID 77

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 2020.06.01
    • Version: chembl_23

    Alternate Names:
    P2RX7 GENE_SYMBOL
    P2X purinoceptor 7 UNIPROT
    ATP receptor UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000089041 Gene Symbol
    P2RX7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 18-August-2020

    Alternate Names:
    PA32866 PharmGKB ID

    Gene Info:

    Publications:

    • Version: 03-September-2020

    Alternate Names:
    P2X purinoceptor 7 Gene Name
    Q99572 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL, NUCLEAR HORMONE RECEPTOR

    Publications:

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications: