• Interaction Score: 3.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Novel drug target Established target

  • Interaction Score: 1.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    17726343


  • Interaction Score: 1.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    22841723


  • Interaction Score: 1.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Potency against recombinant human PDE4C1 isoform in a TR-FRET assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ibudilast, MN-166, AV411
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

  • Interaction Score: 1.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.5

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name EHT 0202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    PDE4C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    PDE4C Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.4.17

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    PDE4C_HUMAN Uniprot Id
    Q08493 Uniprot Accession
    ENSG00000105650 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.1.4.17

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C Uniprot Protein Name
    Q08493 Uniprot Accession
    5143 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR002073
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    PDE4C Display Id
    ENSG00000105650 Ensembl Gene Id
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C (EC 3.1.4.17) (DPDE1) (PDE21). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08493] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    8782 HUGO Gene ID
    8782 HUGO Gene Symbol
    phosphodiesterase 4C HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)
    GuideToPharmacology Gene Category ID 260

    Gene Categories:
    ENZYME

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105650 Gene Symbol
    PDE4C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    DPDE1 GENE_SYMBOL
    PDE4C GENE_SYMBOL
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C UNIPROT

    Gene Info:

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    PDE4C TTD Gene Abbreviation
    T12081 TTD Target ID

    Gene Info:

    Publications: