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PDE5A 8654 Druggable Genome
Alternate Names:
8654 PHOSPHODIESTERASE 5A PDE5A CGB-PDE CN5A PDE5 603310 8784 ENSG00000138735 OTTHUMG00000132971 O76074 PDE5A_HUMAN CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE cGMP-binding cGMP-specific phosphodiesterase CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O76074] T07663 Gene Info:
Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Interpro Acc IPR002073 Interpro Type Domain Interpro Name 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain Interpro Short Name PDEase_catalytic_dom Target Main Class Enzymes Target Subclass 3.1.4.35 Target Class Enzymes Target Subclass EC:3.1.4.35 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
DRUGGABLE GENOME ENZYME Publications:
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Phosphodiesterase 5A inhibitor Direct Interaction yes Trial Name udenafil,Zydena
Sources:
TdgClinicalTrial ChemblInteractions TEND TTD -
Interaction Score: 19.53
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Novel drug target Established target Trial Name avanafil, TA-1790 Mechanism of Interaction Phosphodiesterase 5A inhibitor -
Interaction Score: 6.51
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Interaction Score: 5.11
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Interaction Types & Directionality:
n/a Interaction Info:
Trial Name OSI-461 Novel drug target Established target -
Interaction Score: 3.25
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Phosphodiesterase 5A inhibitor Direct Interaction yes -
Interaction Score: 3.25
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Interaction Score: 3.25
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Phosphodiesterase 5A inhibitor Direct Interaction yes -
Interaction Score: 0.57
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name CRx-102, prednisolone plus dipyridamole,Synavive Novel drug target Established target Trial Name CRx-150, amoxapine plus dipyridamole
Sources:
TdgClinicalTrial ChemblInteractions TEND TTD -
Interaction Score: 0.41
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name ADC4022, low-dose inhaled theophylline Novel drug target Established target -
Interaction Score: 0.38
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes Trial Name pentoxifylline, EHT0201 -
Interaction Score: 0.22
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- Version: 101_38
Alternate Names:
PDE5A Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
ENSG00000138735 Ensembl Gene Id PDE5A Uniprot Gene Name O76074 Uniprot Accession Gene Info:
Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
8654 Entrez Gene Id PDE5A_HUMAN Uniprot Id ENSG00000138735 Ensembl Gene Id Gene Info:
Target Main Class Enzymes Target Subclass 3.1.4.35 Publications:
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- Version: January-2014
Alternate Names:
PDE5A Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:3.1.4.35 Publications:
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- Version: 26-July-2011
Alternate Names:
PDE5A Display Id ENSG00000138735 Ensembl Gene Id CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (EC 3.1.4.17) (CGB-PDE) (CGMP-BINDING CGMP-SPECIFIC PHOSPHODIESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O76074] Description Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000138735 Gene Symbol PDE5A Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
PDE5 GENE_SYMBOL PDE5A GENE_SYMBOL cGMP-specific 3',5'-cyclic phosphodiesterase UNIPROT Gene Info:
Publications:
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- Version: 2020.06.01
Alternate Names:
PDE5A TTD Gene Abbreviation T07663 TTD Target ID Gene Info:
Publications:
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Alternate Names:
cGMP-specific 3',5'-cyclic phosphodiesterase Gene Name O76074 UniProt ID Gene Info:
Gene Categories:
ENZYME Publications: